Using the Two-way composite loading experimental device, the bearing performance of post-grouting drilled shaft under lateral and axial load is studied by full-scale field test. The result of this research reveals that the lateral critical load Hcr and lateral ultimate load Hu are improved when the axial load is applied to post-grouting drilled shaft, the settlement of post-grouting drilled shaft and not grouting drilled shaft increase while the axial load is close to ultimate load, because the settlement of a foundation pile has a relationship with the size of axial load on the top of pile in the damage process of drilled shaft under lateral load, as well as the variation of vertical settlement of normal drilled shaft is more than that of post-grouting drilled shaft, since the non-grouting drilled shaft is more sensitive to the lateral load than the post-grouting drilled shaft.