Experimental study on single biomolecule sensing using MoS₂–graphene heterostructure nanopores

Abstract

Solid-state nanopores play an important role in single-biomolecule sensing such as DNA and protein. However, ultra-short translocation time hinders nanopores from acquiring more detailed information of biomolecules, and further applications...

Ion transport based structural description for in situ synthesized SBA-15 nanochannels in a sub-micropipette

“…Single-channel based artificial nanopore sensors have gained great progress in the field of entity detection. [1][2][3][4][5] However, translocation frequency, limited by the diffusion of analytes into the nanopore confined space, 6 is a great challenge in single nanopores, which may generate ultra-long consumption time for the detection process. To overcome this problem, film-based nanopore arrays become more crucial in improving the throughput and shortening the detection time 7 and have been successfully used for the detection of proteins 6,8 and DNA.…”

Iontronic Sensing Based on Confined Ion Transport

“…Likewise, the determination of the tip diameter of the nanopipette involves utilizing eq 2. 131,133,134 i k j j j y…”

“…The ionic resistance of the conical nanopore ( R ) is determined by solution conductivity (ρ), membrane thickness ( L ), and tip and base diameters ( d tip , d base ) (eq ). The slope of the linear range of the I – V curve is used for R calculation. , R = 4 ρ L π d tip d base Likewise, the determination of the tip diameter of the nanopipette involves utilizing eq . ,, R = 1 k a true( 1 π normaltan nobreak0em.25em⁡ θ + 1 4 true) where k represents the solution conductivity, while R , a , and θ correspond to the resistance, radius of the nanopipette, and half cone angle, respectively. Through this method, it becomes possible to ascertain the accurate aperture size of the glass nanopipette tip within the solution.…”

Nano–Bio Interface of Molybdenum Disulfide for Biological Applications

“…Moreover, Leburton et al [80] developed a systematic algorithmic method to detect the presence of RNA tails on dsDNA using the single MoS 2 membrane nanopores as well as to identify the tail lengths from the transverse conductance signal. Liu's group [81] constructed a MoS 2 /graphene heterostructure nanopores to test both dsDNA and native protein (BSA) at the single-molecule level in experiments. Through the different adsorption capacities of the two materials on biomolecules, the single-biomolecule translocation can be slowed and detailed information about biomolecules can be acquired.…”