While the basic capability of large eddy simulation (LES) has been amply demonstrated on a number of relatively simple academic configurations, there is still a lack of works applying LES to practical systems also performing detailed quantitative comparisons based on experimental data. In this paper, we tend to approach the simulation of real gas turbine combustor step by step as we first present results of the isothermal LES of a generic gas turbine combustor rig. The available detailed measurements are used to thoroughly validate the LES results. Beyond a pure validation, the LES is used to analyze the influence of the precessing vortex core present in the studied configuration on the mixing of fuel and oxidizer, and possible implications for reacting conditions are discussed.