Experimental Study on the Surface Tension, Density, and Viscosity of Aqueous Poly(vinylpyrrolidone) Solutions

Bolten, Dennis; Türk, Michael

doi:10.1021/je101277c

Cited by 44 publications

(32 citation statements)

References 9 publications

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“…In this manner, fluid with different fluid viscosities can be achieved (Bolten and Turk 2011). Pure PBS and a 1.25% PVP solution at room temperature were employed to achieve fluid viscosities of 1.05±0.01 cP and 4.02±0.01 cP, respectively, as measured using a capillary viscometer (model C445, Cannon Instrument Company, State College, PA).…”

Section: Methodsmentioning

confidence: 99%

Fluid Viscosity Affects the Fragmentation and Inertial Cavitation Threshold of Lipid-Encapsulated Microbubbles

Helfield

Black

Qin

et al. 2016

Ultrasound in Medicine & Biology

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Ultrasound and microbubble optimization studies for therapeutic applications are often conducted in water/saline, with a fluid viscosity of 1 cP. In an in vivo context, microbubbles are situated in blood, a more viscous fluid (~4 cP). In this study, ultra-high speed microscopy and passive cavitation approaches were employed to investigate the effect of fluid viscosity on microbubble behavior at 1 MHz subject to high pressures (0.25 – 2 MPa). The propensity for individual microbubble (n=220) fragmentation was shown to significantly decrease in 4 cP fluid as compared to 1 cP fluid, despite achieving similar maximum radial excursions. Microbubble populations diluted in 4 cP fluid exhibited decreased wideband emissions (up to 10.2 times), and increasingly distinct harmonic emission peaks (e.g. ultraharmonic) with increasing pressure as compared to 1 cP fluid. These results suggest that in vitro studies should consider an evaluation using physiologic viscosity perfusate before transitioning to in vivo evaluations.

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Section: Methodsmentioning

confidence: 99%

Fluid Viscosity Affects the Fragmentation and Inertial Cavitation Threshold of Lipid-Encapsulated Microbubbles

Helfield

Black

Qin

et al. 2016

Ultrasound in Medicine & Biology

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“…Plasma viscosity was increased using polyvinylpyrrolidone (PVP) (Sigma-Aldrich, St. Louis, MO, USA), a biologically inert polymer (Bolten and Turk 2011). Blood viscosity in vivo is heavily dependent on shear rate.…”

Section: Methodsmentioning

confidence: 99%

Effect of Thrombus Composition and Viscosity on Sonoreperfusion Efficacy in a Model of Micro-Vascular Obstruction

Black

Schnatz

et al. 2016

Ultrasound in Medicine & Biology

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Distal embolization of microthrombi during stenting for myocardial infarction (MI) causes microvascular obstruction (MVO). We have previously shown that sonoreperfusion (SRP), a microbubble (MB)-mediated ultrasonic (US) therapy, resolves MVO from venous microthrombi in vitro in saline. However, blood is more viscous than saline and arterial thrombi that embolize during stenting are mechanically distinct from venous clot. Therefore, we tested the hypothesis that MVO created with arterial microthrombi are more resistant to SRP therapy compared with venous microthrombi and higher viscosity further increases the US requirement for effective SRP in an in vitro model of MVO. Lipid MB suspended in plasma with adjusted viscosity (1.1 or 4.0 cP) were passed through tubing bearing a mesh with 40 μm pores to simulate a microvascular cross-section; upstream pressure reflected thrombus burden. To simulate MVO, the mesh was occluded with either arterial or venous microthrombi to increase upstream pressure to 40±5 mmHg. Therapeutic long-tone-burst US was delivered to the occluded area for 20 min. MB activity was recorded with a passive cavitation detector (PCD). MVO caused by arterial microthrombi at either blood or plasma viscosity resulted in less effective SRP therapy, compared to venous thrombi. Higher viscosity further reduced the effectiveness of SRP therapy. PCD showed a decrease in inertial cavitation when viscosity was increased while stable cavitation was affected in a more complex manner. Overall, these data suggest that arterial thrombi may require higher acoustic pressure US than venous thrombi to achieve similar SRP efficacy, increased viscosity decreases SRP efficacy, and both inertial and stable cavitation are implicated in observed SRP efficacy.

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“…Furthermore PVP is widely used in pharmacy, and detergent industry [6]; therefore, a considerable amount of research has been conducted devoting to PVP solutions. The previous findings indicate that addition of ionic and nonionic solutes to aqueous PVP solutions disrupts hydrogen bonds or molecular association of polymers.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic and viscometric studies on the interaction of ionic liquid, 1-butyl-3-methylimidazolium bromide with polyvinyl pyrrolidone

Mehrdad

Niknam

2015

Fluid Phase Equilibria

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Experimental Study on the Surface Tension, Density, and Viscosity of Aqueous Poly(vinylpyrrolidone) Solutions

Cited by 44 publications

References 9 publications

Fluid Viscosity Affects the Fragmentation and Inertial Cavitation Threshold of Lipid-Encapsulated Microbubbles

Fluid Viscosity Affects the Fragmentation and Inertial Cavitation Threshold of Lipid-Encapsulated Microbubbles

Effect of Thrombus Composition and Viscosity on Sonoreperfusion Efficacy in a Model of Micro-Vascular Obstruction

Spectroscopic and viscometric studies on the interaction of ionic liquid, 1-butyl-3-methylimidazolium bromide with polyvinyl pyrrolidone

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