For the marine industry, resistance reduction can reduce energy consumption and achieve protection of the marine environment. The use of air lubrication to reduce the resistance of ships is one of the most important ways. With this technology, high-speed air cavity crafts show immense potential as they can be utilized in various marine activities, such as emergency rescue, supply, and maritime security. Through experiments, this study presents an in-depth analysis of the effects of bubble chamber pressure and initial stern inclination on the resistance of high-speed air cavity crafts at different speeds. The results show that air pressure has a significant impact on resistance. It was found that as the speed of the ship increased, the resistance reduction effect became more prominent under the same pressure conditions. Moreover, the resistance tended to stabilize when the pressure reached a certain value. In addition to the air pressure, the longitudinal inclination does have an effect on resistance reduction. To achieve better resistance reduction, the initial stern inclination angle should be chosen appropriately. Furthermore, adjusting the angle with speed changes can optimize the resistance reduction effect. This experimental study provides critical support for conducting further research on high-speed air cavity crafts. The findings offer valuable insights into improving hull forms, guiding host selection, and assessing performance.