Experimental Swine Lung Autotransplant Model to Study Lung Ischemia–Reperfusion Injury

Adiego, Carlos Simón; González-Casaurrán, Guillermo; Perea, Leire Azcárate; Viña, Jesus Isea de la; Ameigeiras, Elena Vara; Martín, Cruz; Garutti, Ignacio; Casanova, Javier; López, Ángeles; Piñeiro, Beatriz Martín; González-Aragoneses, Federico

doi:10.1016/j.arbr.2011.02.002

Cited by 9 publications

References 35 publications

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Lung Ischaemia–Reperfusion Injury: The Role of Reactive Oxygen Species

Pak

Sydykov

Kosanovic

et al. 2017

Advances in Experimental Medicine and Biology

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Lung ischaemia-reperfusion injury (LIRI) occurs in many lung diseases and during surgical procedures such as lung transplantation. The re-establishment of blood flow and oxygen delivery into the previously ischaemic lung exacerbates the ischaemic injury and leads to increased microvascular permeability and pulmonary vascular resistance as well as to vigorous activation of the immune response. These events initiate the irreversible damage of the lung with subsequent oedema formation that can result in systemic hypoxaemia and multi-organ failure. Alterations in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been suggested as crucial mediators of such responses during ischaemia-reperfusion in the lung. Among numerous potential sources of ROS/RNS within cells, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, xanthine oxidases, nitric oxide synthases and mitochondria have been investigated during LIRI. Against this background, we aim to review here the extensive literature about the ROS-mediated cellular signalling during LIRI, as well as the effectiveness of antioxidants as treatment option for LIRI.

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