Experimental use of fibrin glue derived from snake venom in non-pregnant canine uterus

Abstract

This study evaluated the use of fibrin glue derived from snake venom in the healing process after canine hysterorrhaphy. Three groups of four animals were submitted to uterine hysterotomy followed by wound closure. In Group 1, double-layer suture was used, the first with Schimieden pattern, the second with Cushing pattern; in Group 2, only fibrin glue; and in Group 3, the same as for Group 1 but with fibrin glue as suture reinforcement. Results indicated that fibrin glue produced less inflammation in the exudative phase, and exacerbated deposition of connective tissue and angiogenesis in the proliferative and maturation phases of the healing process, favoring its evolution

Effect of low-level laser therapy (LLLT) on peripheral nerve regeneration using fibrin glue derived from snake venom

“…These components were reconstituted in liquid state, generating a net of fibrin and were kindly provided by the Center for the Study of Venoms and Venomous Animals [13,21,23].…”

A new heterologous fibrin sealant as a scaffold to cartilage repair—Experimental study and preliminary results

“…20,21 Snake-derived fibrin gel also stimulates granulation tissue and does not trigger a strong inflammatory response. 13 In our study, the rapid and normal generation of fibrocartilage, which completely filled the injury site in G2, showed the inert or beneficial effects of the gel implantation; however, detailed studies and quantitative analysis of innate and adaptive immunological response are still required, at different time points after implantation.…”

“…1,11 The fibrin gel obtained from the venom of the Crotalus durissus terrificus snake, a rattlesnake, contains serinoprotease, a protein in the venom that has been characterized as thrombin-like and acts in a similar manner as thrombin. 12 In fact, this snake-derived fibrin gel has been used as a hemostatic agent to improve the healing of tissues, [13][14][15] and this formulation seems to presents all of the beneficial characteristics that accompany the common fibrin sealant.…”

“…The gel from the venom of the rattlesnake also possesses anti-inflammatory properties, 14 and this material was previously used in other studies 13 to evaluate the healing of hysterectomies performed in female dogs. Fibrin gel from snake venom was selected for this study because previous studies performed by CEVAP in Botucatu showed satisfactory use of this sealant with promising results; in particular, this gel performed in a similar way to previously developed fibrin sealant.…”

Purification and partial characterization of a coagulant serine protease from the venom of the Iranian snake Agkistrodon halys

“…Additionally, these enzymes are employed in deep corneal ulcer repair and non-pregnant canine uterus (16,17). A study on the efficacy of fibrin glue derived from snake venom in colon anastomosis of rats was carried out by Leite et al (14).…”