Experimental validation of the linear drive train for a total artificial heart system

Pohlmann, André; Leßmann, Marc; Fritschi, Andreas; Finocchiaro, Thomas; Steinseifer, Ulrich; Hameyer, Kay

doi:10.1016/j.mechatronics.2012.03.007

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…A sinusoidal displacement with a systole-diastole time ratio of 1:1, a peak-to-peak amplitude of 18 mm and a frequency of 100 bpm (0.6 s for one pump cycle) was applied to the pusher plate. This frequency was chosen for this study because the pump runs with at least 100 bpm to achieve the required perfusion of 6 l/min (20) and, therefore, the worst washout is expected. The ratio of 1:1 was evaluated in vitro to be the most efficient operation point as far as acceleration, stroke volume, and left-right flow balance are concerned.…”

Section: Methodsmentioning

confidence: 99%

Numerical Washout Study of a Pulsatile Total Artificial Heart

et al. 2014

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Section: Methodsmentioning

confidence: 99%

Numerical Washout Study of a Pulsatile Total Artificial Heart

et al. 2014

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“…[3][4][5] The development of a patented linear actuator formed the basis for the TAH ReinHeart. [6][7][8] The TAH replaces the function of the natural heart and is implanted as an orthotopic heart replacement with complete excision of both ventricles. Several studies have demonstrated the proof of concept, as well as initial results in terms of durability, 9 hemocompatibility, 10 implantable driver electronics, 11,12 and preliminary in vivo performance.…”

Section: Introductionmentioning

confidence: 99%

“…For several decades, the research on an artificial heart replacement has been carried out at the Helmholtz Institute in Aachen 3‐5 . The development of a patented linear actuator formed the basis for the TAH ReinHeart 6‐8 . The TAH replaces the function of the natural heart and is implanted as an orthotopic heart replacement with complete excision of both ventricles.…”

Section: Introductionmentioning

confidence: 99%

Controlling the flow balance: In vitro characterization of a pulsatile total artificial heart in preload and afterload sensitivity

et al. 2021

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The objective of this study is to identify the preload and afterload sensitivity of the ReinHeart TAH 2.0. For adequate left-right flow balance, the concept of a reduced right stroke volume (by about 10%) and active adaption of the right diastole duration are evaluated concerning the controllability of the flow balance. This study used an active mock circulation loop to test a wide range of preload and afterload conditions.Preload sensitivity was tested at atrial pressures (APs) between 4 and 20 mm Hg. Left afterload was varied in a range of 60-140 mm Hg mean aortic pressure (MAP), right afterload was simulated between 15 and 40 mm Hg. Four scenarios were developed to verify that the flow difference fully covers the defined target range of 0-1.5 L/min. Although a positive correlation between inlet pressure and flow is identified for the right pump chamber, the left pump chamber already fills completely at an inlet pressure of 8-10 mm Hg. With increasing afterload, both the left and right flow decrease.A positive flow balance (left flow exceeds right flow) is achieved over the full range of tested afterloads. At high APs, the flow difference is limited to a maximum of 0.7 L/min. The controllability of flow balance was successfully evaluated in four scenarios, revealing that a positive flow difference can be achieved over the full range of MAPs. Under physiological test conditions, the linear relationship between flow and heart rate was confirmed, ensuring good controllability of the TAH.

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“…In addition, electrical machines are integrated into a wide variety of environments, e.g. as in total artificial heart [2]. As a result, each design of an electrical machine is based on individual requirements and boundary conditions.…”

Section: Introductionmentioning

confidence: 99%