Experimentally constrained circuit model of cortical arteriole networks for understanding flow redistribution due to occlusion and neural activation

Bollu, Tejapratap; Cornelius, Nathan R.; Sunwoo, John; Nishimura, Nozomi; Schaffer, Chris B.; Doerschuk, Peter C.

doi:10.1177/0271678x17741086

Cited by 8 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is accomplished by a network of downstream, yet inter-connected vessels that reverse their flow to direct blood towards the location of the clot after the insult (Schaffer et al, 2006;Shih et al, 2015;Reeson et al, 2018). This redundancy makes pial circulation highly resistant to ischemic damage resulting from a single occlusion (Schaffer et al, 2006;Shih et al, 2013Shih et al, , 2015Bollu et al, 2018).…”

Section: Redundancy In the Cerebral Vasculaturementioning

confidence: 99%

Susceptibility to capillary plugging can predict brain region specific vessel loss with aging

Schager

Brown

2020

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Vessel loss in the aging brain is commonly reported, yet important questions remain concerning whether there are regional vulnerabilities and what mechanisms could account for these regional differences, if they exist. Here we imaged and quantified vessel length, tortuosity and width in 15 brain regions in young adult and aged mice. Our data indicate that vessel loss was most pronounced in white matter followed by cortical, then subcortical grey matter regions, while some regions (visual cortex, amygdala, thalamus) showed no decline with aging. Regions supplied by the anterior cerebral artery were more vulnerable to loss than those supplied by middle or posterior cerebral arteries. Vessel width and tortuosity generally increased with age but neither reliably predicted regional vessel loss. Since capillaries are naturally prone to plugging and prolonged obstructions often lead to vessel pruning, we hypothesized that regional susceptibilities to plugging could help predict vessel loss. By mapping the distribution of microsphere-induced capillary obstructions, we discovered that regions with a higher density of persistent obstructions were more likely to show vessel loss with aging and vice versa. These findings indicate that age-related vessel loss is region specific and can be explained, at least partially, by regional susceptibilities to capillary plugging.

show abstract

Section: Redundancy In the Cerebral Vasculaturementioning

confidence: 99%

Susceptibility to capillary plugging can predict brain region specific vessel loss with aging

Schager

Brown

2020

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…Problem emerges when it comes to the pia, which holds up pial arterioles and MGMs parallelly. Since MGMs tend to evenly distribute on the pia surface, some MGMs may happen to overlap with pial arterioles while others may not . As for those overlapping with pial arterioles, it is hard to define if they are MGMs or PVMs.…”

Section: Pvm Characterizationmentioning

confidence: 99%

“…Since MGMs tend to evenly distribute on the pia surface, some MGMs may happen to overlap with pial arterioles while others may not. 4,31 As for those overlapping with pial arterioles, it is hard to define if they are MGMs or PVMs. Out of this concern, all the data in the present article exclude the pial vessels and only focus on penetrating vessels.…”

Section: Markers Of Pvmsmentioning

confidence: 99%

Brain perivascular macrophages: Recent advances and implications in health and diseases

2019

View full text Add to dashboard Cite

Brain perivascular macrophages (PVMs) belong to a distinct population of brain‐resident myeloid cells located within the perivascular space surrounding arterioles and venules. Their characterization depends on the combination of anatomical localization, phagocytic capacity, and molecular markers. Under physiological status, they provide structural and functional support for maintaining brain homeostasis, including facilitation of blood‐brain barrier integrity and lymphatic drainage, and exertion of immune functions such as phagocytosis and antigen presentation. Increasing evidence also implicates their specific roles in diseased brain, ranging from cerebrovascular diseases, Aβ pathologies, infections, and autoimmunity. Collectively, PVMs are key components of the brain‐resident immune system, actively participate in a broad‐spectrum of processes in normal and diseased status. Details of the processes are largely underexplored. Targeting PVMs would lead to new insights and be a promising strategy for a broad array of human diseases.

show abstract

“…Bollu et al studied the effects of occlusion on the arterioles and capillaries in the cerebral microcirculation . A 3‐dimensional network model of the vasculature supplying the surface of the cortex was developed to predict the redistribution of blood flow after microvascular strokes.…”

Section: Introductionmentioning

confidence: 99%

Modeling acute blood flow responses to a major arterial occlusion

et al. 2020

View full text Add to dashboard Cite

Objective The development of earlier and less invasive treatments for peripheral arterial disease requires a more complete understanding of vascular responses following a major arterial occlusion. A mechanistic model of the vasculature of the rat hindlimb is developed to predict acute (immediate) changes in vessel diameters and smooth muscle tone following femoral arterial occlusion. Methods Vascular responses of collateral arteries and distal arterioles to changes in pressure, shear stress, and metabolism are assessed before and after occlusion. The effects of exercise are also simulated and compared with venous flow measurements from WKY rats. Results The model identifies collateral arteries as the primary contributors to flow compensation following occlusion. Increasing the number of capillaries has minimal effect on blood flow while increasing the number of collateral arteries significantly increases flow, since the primary site of resistance shifts upstream to the collateral arteries following occlusion. Despite significant collateral dilation, calf flow remains below pre‐occlusion levels and the deficit becomes more severe with increased activity. Conclusions Although unable to compensate fully for an occlusion, the model demonstrates the importance of the shear response in collateral arteries and the metabolic response in the distal microcirculation in acute adaptations to a major arterial occlusion.

show abstract

Experimentally constrained circuit model of cortical arteriole networks for understanding flow redistribution due to occlusion and neural activation

Cited by 8 publications

References 33 publications

Susceptibility to capillary plugging can predict brain region specific vessel loss with aging

Susceptibility to capillary plugging can predict brain region specific vessel loss with aging

Brain perivascular macrophages: Recent advances and implications in health and diseases

Modeling acute blood flow responses to a major arterial occlusion

Contact Info

Product

Resources

About