Experimentally induced immunity in the mycoses.

Kong, Y C; Levine, Howard B.

doi:10.1128/mmbr.31.1.35-53.1967

Cited by 35 publications

(12 citation statements)

References 49 publications

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“…Initial studies with Blastomyces dermatitidis indicated that the organism produced a minimal immunogenic response in experimental animals (11). Later studies, however, indicated that i.p.…”

Section: Discussionmentioning

confidence: 99%

Protection against pulmonary blastomycosis: correlation with cellular and humoral immunity in mice after subcutaneous nonlethal infection

Morozumi¹,

Brummer²,

Stevens³

1982

Infect Immun

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A model of pulmonary blastomycosis in the mouse, in which the portal of entry is the same as natural human infection, was used to study resistance to challenge after subcutaneous infection. One week after subcutaneous infection, mice were partially resistant to pulmonary challenge, and mice challenged two weeks after infection were resistant. Measurement of cellular and humoral immune responses to Blastomyces dermatitidis antigens after subcutaneous infection showed the following. (i) Delayed-type hypersensitivity appeared 1 week after infection, and responses increased for 3 weeks thereafter. (ii) Proliferative responses in vitro appeared in spleen cells at 1 week and in contralateral lymph node cells at 3 weeks, (iii) Serum antibody, detected by an enzyme-linked immunosorbent assay, appeared 1 week after infection and then increased in titer. (iv) Peritoneal macrophages were activated to inhibit replication of B. dermatitidis in vitro by the first week after infection. Prior subcutaneous infection also resulted in rapid clearing of a second subcutaneous challenge, as well as resistance to a lethal intraperitoneal challenge. This resistance was associated with the development of cell-mediated and humoral immune responses. These data provide a chronological framework for selective transfer experiments.

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“…Initial studies with Blastomyces dermatitidis indicated that the organism produced a minimal immunogenic response in experimental animals (11). Later studies, however, indicated that i.p.…”

Section: Discussionmentioning

confidence: 99%

Protection against pulmonary blastomycosis: correlation with cellular and humoral immunity in mice after subcutaneous nonlethal infection

Morozumi¹,

Brummer²,

Stevens³

1982

Infect Immun

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“…This is surprising because the dimorphic fungi seem particularly suitable for studies of pathogenicity. The yeast forms predominate in vivo and appear to be more pathogenic and immunogenic than the mycelial/arthrospore forms which, although they occur, are less prevalent in vivo (55,68,100,116). The two forms are antigenically and chemically different (68, 70, 100), and studies of pathogenicity could benefit from comparing them in appropriate biological tests, and from observations of the influence of the products of one on the behavior of the other.…”

Section: Fungimentioning

confidence: 99%

“…Peptidases may be involved in the toxic action of dermatophytes (22). Hypersensitivity undoubtedly occurs in many fungal diseases and probably explains to a large degree the pathology of some fungal skin diseases; however, the degree to which hypersensitivity is implicated in the main pathology of deep mycoses is a matter of conjecture (55,68). The compounds responsible for these hypersensitivities are many (even for one fungus) and are ill-defined chemically, although some progress has been made with products of dermatophytes (9).…”

Section: Fungimentioning

confidence: 99%

Biochemical challenge of microbial pathogenicity.

Smith¹

1968

Bacteriological Reviews

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“…In this review, I will summarize the recent advances made in the identification and generation of possible vaccine candidates for medically important fungi. Much of the work prior to the 1980s will not be discussed, and readers interested in the historical perspective are referred to two excellent comprehensive reviews (56,90). The reader should note that although vaccination and immunization often are used interchangeably, they have, strictly speaking, different meanings.…”

Section: Introductionmentioning

confidence: 99%

Prospects for the development of fungal vaccines

Deepe

1997

Clin Microbiol Rev

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In an era that emphasizes the term "cost-effective," vaccines are the ideal solution to preventing disease at a relatively low cost to society. Much of the previous emphasis has been on childhood scourges such as measles, mumps, rubella, poliomyelitis, and Haemophilus influenzae type b. The concept of vaccines for fungal diseases has had less impact because of the perceived limited problem. However, fungal diseases have become increasingly appreciated as serious medical problems that require recognition and aggressive management. The escalation in the incidence and prevalence of infection has prompted a renewed interest in vaccine development. Herein, I discuss the most recent developments in the search for vaccines to combat fungal infections. Investigators have discovered several inert substances from various fungi that can mediate protection in animal models. The next challenge will be to find the suitable mode of delivery for these immunogens.

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Experimentally induced immunity in the mycoses.

Abstract: A co ntribution to the round table "Respiratory Mycoses: Comparative Epidemiology, Ecology, and Immunology," held at the Annual Meeting of the American Society for Microbiology, Los Angeles, Calif., 3 May 1966, with Roger 0. Egeberg as convener.

Cited by 35 publications

References 49 publications

Protection against pulmonary blastomycosis: correlation with cellular and humoral immunity in mice after subcutaneous nonlethal infection

Protection against pulmonary blastomycosis: correlation with cellular and humoral immunity in mice after subcutaneous nonlethal infection

Biochemical challenge of microbial pathogenicity.

Prospects for the development of fungal vaccines

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