Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group

Ai, Hui‐Sheng; Chao, Nelson J.; Rizzieri, David A.; Huang, Xiao‐Jun; Spitzer, Thomas R.; Wang, Jianxiang; Guo, Mingzhou; Keating, Armand; Krakow, Elizabeth F.; Blaise, Didier; Ma, Jun; Wu, Depei; Reagan, John L.; Gergis, Usama; Duarte, Rafael F.; Chaudhary, Preet M.; Hu, Kaiwen; Yu, Chengbin; Sun, Qi‐Yun; Fuchs, Ephraim J.; Cai, Bo; Huang, Ya‐Jing; Qiao, Jie; Gottlieb, David; Schultz, Kirk R.; Liu, Mingyao; Chen, Xiequn; Chen, Wen-Ming; Wang, Jianmin; Zhang, Xiaohui; Li, Jianyong; Hui, He; Sun, Zimin; Li, Fēi; Yang, Linhua; Zhang, Liansheng; Li, Lijuan; Liu, Kai-Yan; Jin, Jie; Liu, Qifa; Liu, Dai‐Hong; Gao, Chunji; Fan, Cheng; Li, Wei; Zhang, Xi; Hu, Liangding; Zhang, Weijing; Tian, Yuyang; Han, Weidong; Zhu, Jun; Xiao, Zhijian; Zhou, Daobin; Zhang, Bolong; Jia, Yong-Qian; Zhang, Yongqing; Wu, Xiaofeng; Shen, Xu-Liang; Lu, Xuzhang; Zhan, Xin-Rong; Sun, Xuping; Xiao, Yi; Wang, Jingbo; Shi, Xiaodong; Zheng, B.; Chen, Jieping; Ding, Banghe; Wang, Zhao; Zhou, Fan; Zhang, Mei; Zhang, Yizhuo; Sun, Jie; Xia, Bing; Chen, Baoan; Ma, Liangming

doi:10.1016/j.heliyon.2023.e14924

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e14924

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Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group

Hui‐Sheng Ai¹,

Nelson J. Chao²,

David A. Rizzieri³

et al.

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Cited by 3 publications

References 77 publications

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Hematopoietic stem cell microtransplantation: current situation and challenges

Li,

Yang,

Peng

et al. 2025

Therapeutic Advances in Hematology

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) stands as a cornerstone in the treatment of hematological malignancies, recognized for its remarkable efficacy. However, the persistent challenge of graft-versus-host disease (GVHD) continues to represent a significant barrier, often being the leading cause of nonrelapse mortality after allo-HSCT. To address this limitation, hematopoietic stem cell microtransplantation (MST) has emerged as a novel therapeutic strategy that synergistically combines chemotherapy, allo-HSCT, and cellular immunotherapy. This innovative approach is designed to retain the patient’s immune function, promote the establishment of microchimerism, and achieve a potent graft-versus-tumor (GVT) response, all while significantly minimizing the risk of GVHD. MST has primarily been applied in the treatment of hematological malignancies, where it has demonstrated promising outcomes, including marked improvements in complete remission rates, overall survival rates, and progression-free survival rates. Moreover, MST facilitates hematopoietic recovery, decreases the likelihood of infections, and reduces the incidence of GVHD, thus contributing to an improved quality of life for patients. A deeper and more comprehensive understanding of MST’s mechanisms could enhance its clinical utility and integration into standard treatment protocols. This review aims to explore the underlying mechanisms, current clinical applications, and challenges of MST, shedding light on its potential role in advancing the management of hematological malignancies.

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Hematopoietic stem cell microtransplantation: current situation and challenges

Li,

Yang,

Peng

et al. 2025

Therapeutic Advances in Hematology

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Sirtuin 5 regulates acute myeloid leukemia cell viability and apoptosis by succinylation modification of glycine decarboxylase

Zhang,

Luo,

Long

2024

Open Life Sciences

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Acute myeloid leukemia (AML) is a blood system malignancy where sirtuin 5 (SIRT5) is abnormally expressed in AML cell lines. This study aimed to investigate the SIRT5 effects on the viability and apoptosis of AML cell lines. The mRNA and protein expression levels of succinylation regulatory enzyme in clinical samples and AML cell lines were detected by real-time quantitative polymerase chain reaction and western blotting while cell viability was measured using cell counting kit-8 assay. The apoptosis rate was assessed with flow cytometry. The interaction between SIRT5 and glycine decarboxylase (GLDC) was determined by co-immunoprecipitation and immunofluorescence staining techniques. Results indicated higher mRNA and protein expression levels of SIRT5 in clinical AML samples of AML than in normal subjects. Similarly, cell viability was inhibited, and apoptosis was promoted by downregulating SIRT5, in addition to inhibition of SIRT5-mediated GLDC succinylation. Moreover, rescue experiment results showed that GLDC reversed the effects of SIRT5 knockdown on cell viability and apoptosis. These results, in combination with SIRT5 and GLDC interactions, suggested that SIRT5 was involved in mediating AML development through GLDC succinylation. SIRT5 inhibits GLDC succinylation to promote viability and inhibit apoptosis of AML cells, suggesting that SIRT5 encourages the development of AML.

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“Lazarus Response” When Feto-Maternal Microchimerism Kicks in: Spontaneous Remission in Refractory Primary Mediastinal B Cell Lymphoma Following Twin Pregnancy

Tomai,

Iluta,

Tigu

et al. 2024

Diagnostics

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Background: Spontaneous remission of cancer is a rare and poorly understood phenomenon characterized by complete or partial remission of a malignancy in the absence of or with inadequate treatment. The underlying mechanism for such occurrences is poorly understood, however, immune mechanisms seem to play an important role in such cases. In recent years increasingly more data have become available in favor of the clinical benefit of low levels of chimerism in hematologic malignancies. One such instance of naturally occurring low-level chimerism is feto-maternal microchimerism which has been shown to influence cancer progression and, in some instances, to be a protective factor against malignancy. Case report: We report a case of a young female patient with aggressive primary mediastinal large B cell lymphoma refractory to two lines of chemo-immunotherapy achieving sustained complete metabolic remission of tumor while pregnant with twins. Results: A focus on feto-maternal microchimerism during and after pregnancy revealed transient levels of feto-maternal microchimerism in the peripheral blood of the patient as measured by quantifying the Y-chromosome-linked SRY gene. Conclusions: Microchimerism presents significant potential for enhancing our comprehension of disease mechanisms, uncovering novel therapeutic targets, and refining diagnostic and treatment approaches, especially concerning cancer.

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Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group

Cited by 3 publications

References 77 publications

Hematopoietic stem cell microtransplantation: current situation and challenges

Hematopoietic stem cell microtransplantation: current situation and challenges

Sirtuin 5 regulates acute myeloid leukemia cell viability and apoptosis by succinylation modification of glycine decarboxylase

“Lazarus Response” When Feto-Maternal Microchimerism Kicks in: Spontaneous Remission in Refractory Primary Mediastinal B Cell Lymphoma Following Twin Pregnancy

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