Expert consensus statement on computed tomography-guided 125I radioactive seeds permanent interstitial brachytherapy

Abstract

The aim of this study is to develop expert consensus statement for recommendations of patient selection criteria, prescription dose, and procedure of computed tomography (CT)-guided I radioactive seeds permanent interstitial brachytherapy. Members of Chinese medical association radiation oncology branch, Chinese medical association radiation therapy professional committee, Chinese cancer society minimally invasive surgery branch seed therapy group, Chinese geriatric cancer society minimally invasive surgery branch, Beijing medical association radiation oncology professional committee, China northern radioactive seeds brachytherapy group formed a committee, which consists of physician members who come from the department of radiation oncology, surgery, intervention, internal medicine, ultrasound, and nuclear medicine. The leader of the group organized experts to write the first draft based on clinical experience and literature review and then sent the draft to the commissioner for consultation, finally reached a consensus. Guidelines for patient selection criteria, prescription dose ofI seed for different kinds of carcinomas, activity of per seed, and workflow of CT-guided permanent interstitial radioactive seed implantation (RSI) are presented in this study. The procedure of CT-guided RSI comprised eight steps: indication selection, preoperative preparation, preoperative CT simulation and position setup, preplan, intraoperative needle insertion, RSI, postoperative dosimetric evaluation, and follow-up. Patient selection criteria are developed. Guidelines for prescription dose of I seed for different kinds of carcinomas, activity of per seed, and workflow of CT-guided permanent interstitial RSI are provided.

Evaluation of radioactive 125I seed implantation for the treatment of refractory malignant tumors based on CT-guided 3D template assisted technique: efficacy and safety

“…CT-guided 125 I seed implantation in the treatment of malignant tumors has been included into the treatment instruction in China, which makes this treatment more standardized [21]. In this study, from the point of exploring the long-term efficacy and safety of CT-guided 3D template-assisted 125 I seed implantation in the treatment of malignant tumors for refractory malignancies, and conducted a 2-year clinical follow-up observation, combined with post-operative verification of relevant dosimetric parameters, which further confirm the clinical efficacy and safety of the technique and the rationality of the treatment.…”

Oligorecurrence Non–small Cell Lung Cancer After Failure of First-Line Chemotherapy: Computed Tomography–Guided 125I Seed Implantation vs. Second-Line Chemotherapy

“…Then CT images were uploaded into a treatment planning system. Radiation physicians outlined the gross tumor volume (GTV) on each transverse image and determined the prescription dose [according to international standards for prostate cancer and expert consensus on RIS brachytherapy (18,21)]. And the total number and activity of seed to be implanted were calculated via the modified level formula (22) (Figure 1B).…”

“…It is a type of low-dose-rate brachytherapy, which could deliver high radiation dose to target tumor while safely sparing the adjacent normal tissue. Previous studies indicated that 125 I brachytherapy is a feasible salvage treatment method for many cancers, including prostate cancer, lung cancer, pancreatic cancer, and head and neck cancer (18). To a certain extent, RIS implantation brachytherapy is similar to a single dose of stereotactic ablative radiotherapy and can also be called "stereotactic ablative brachytherapy" (16).…”

Improved Prognosis for Recurrent Epithelial Ovarian Cancer By early Diagnosis and 125I Seeds Implantation During Suboptimal Secondary Cytoreductive Surgery: A Case Report and Literature Review

“…In 1999, there has been American Brachytherapy Society (ABS) recommendations for the clinical quality assurance and guidelines of permanent prostate brachytherapy with 125I 12 . In 2018, Chinses expert consensus statement on computed tomography-guided 125 I radioactive seeds permanent interstitial brachytherapy has been developed 13 .…”