Artificial intelligence (AI) is paving the way towards Fire 4.0, and the next few years will be elemental to how this technology transforms our academia, practice, and entrepreneurship. Despite the growing interest between fire researchers and practitioners, AI remains absent from our curriculum and we continue to lack a methodical framework to adopt, apply and create AI solutions suitable for our domain. To grow beyond the traditionally favored three-stepped linear process to AI (i.e., collect data fi apply algorithms fi arrive at predictions) and in pursuit of negating the notion of ''history repeats itself'' (e.g., look at the continued debate with regard to modernizing standardized fire testing, etc.), it is the motivation behind this letter to jump-start strategic discussions on the front of AI & Fire.In parallel, this letter intends to demystify some of the most fundamental concepts and to clear common misconceptions specific to AI on the frontier of fire. Broadly, this letter comprises two sections. The first section outlines big ideas pertaining to AI, and answers some of the burning questions with regard to the merit of adopting AI in our domain. The second section presents a set of rules 1 or technical recommendations an AI user may deem helpful to practice whenever AI is used as a method of investigation. The presented set of rules is complementary to the big ideas. One can think of this short letter as a companion to the Smart Systems in Fire Engineering special issue sponsored by Fire Technology [1]-where an