1993
DOI: 10.1111/1523-1747.ep12465391
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Exploitation of Pigment Biosynthesis Pathway as a Selective Chemotherapeutic Approach for Malignant Melanoma.

Abstract: Human malignant melanoma represents a difficult therapeutic challenge to both medical scientists and practicing physicians. However, the biologic uniqueness of the tumor may provide opportunities for exploitation in therapeutics. This study proposed to undertake a systemic approach to the chemotherapy of malignant melanoma based upon the uniqueness of pigment-cell metabolic pathway pertaining to conversion of tyrosine and dopa with subsequent formation of melanin by tyrosinase and its related enzymes. The sulp… Show more

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Cited by 23 publications
(24 citation statements)
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“…Therefore, tyrosinase inhibitors may be clinically useful for the treatment of skin cancer (Jimbow et al, 1993). Also, recently, more attention is being paid to the use of natural plant extracts in the cosmetic industry as tyrosinase inhibitors for active depigmentation (Prasad et al, 2010); insecticide properties have also been associated with inhibition of insect tyrosinase (El Nagar et al, 2012).…”
Section: Extractsmentioning
confidence: 99%
“…Therefore, tyrosinase inhibitors may be clinically useful for the treatment of skin cancer (Jimbow et al, 1993). Also, recently, more attention is being paid to the use of natural plant extracts in the cosmetic industry as tyrosinase inhibitors for active depigmentation (Prasad et al, 2010); insecticide properties have also been associated with inhibition of insect tyrosinase (El Nagar et al, 2012).…”
Section: Extractsmentioning
confidence: 99%
“…Metastatic melanoma cells are pigmented because active tyrosinase of the melaninsynthesizing pathway is found in melanocytes (Riley, 1991). Thus, the unique ability of melanocytes to produce melanin pigment could be exploited in an enzyme directed melanoma therapy (Jimbow et al, 1993). The selective toxicity of phenolic antimelanoma agents toward local and metastatic melanoma cells could be achieved if the phenolic agent were bioactivated by melanoma tyrosinase to form reactive o-quinones as long as the agent was not bioactivated by hepatic or renal cytochrome P450.…”
Section: Introductionmentioning
confidence: 99%
“…Tyrosine analogues, which are tyrosinase substrates, are good candidates for developing drugs for melanoma-targeting chemotherapies [17]. 4-PCA is a better substrate for tyrosinase than 2-PCA because the structure of 4-PCA is more similar to tyrosine than 2-PCA [3,5,18].…”
Section: Discussionmentioning
confidence: 99%