Exploiting the physicochemical properties of dendritic polymers for environmental and biological applications

Bhattacharya, Priyanka; Geitner, Nicholas K.; Sarupria, Sapna; Ke, Pu Chun

doi:10.1039/c3cp44591g

Cited by 31 publications

(31 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our zeta-potential characterization of G4-NH 2 and G4-SA suggests that approximately 30% of the G4-SA tertiary amines are protonated (Figure 2c) assuming tertiary amines in G4-NH 2 are not protonated. 22 This change allows strong electrostatic interaction between terminal groups and the protonated tertiary amines, which causes the dendrimer to contract relative to the less protonated G4-SA dendrimers. Such strong electrostatic interaction also noticeably inhibits size expansion with temperature in contrast to the weaker hydrogen bond interaction in G4-OH (Figure 2a).…”

Section: Environmental Science and Technologymentioning

confidence: 99%

Structure–Function Relationship of PAMAM Dendrimers as Robust Oil Dispersants

Geitner

Wang

Andorfer

et al. 2014

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

PAMAM dendrimers have recently been investigated as efficient and biocompatible oil dispersants utilizing their encapsulation capacity; however, their high cationic charge density has been shown to be cytotoxic. It is therefore imperative to mitigate cationic charge-induced toxicity and understand the effects of such changes. Presented here is a synergistic experimental and computational approach to examine the effects of varying terminal surface charge on the capacity of dendrimers to disperse model liner, polycyclic aromatic, and hybrid hydrocarbons. Uncharged dendrimers collapse by forming intramolecular hydrogen bonds, which reduce the hosting capability. On the other hand, changing the surface charges from positive to negative greatly shifts the pK a of tertiary amines of the PAMAM dendrimer interior. As a result, the negatively charged dendrimers have a significant percentage of tertiary amines protonated, ∼30%. This unexpected change in the interior protonation state causes electrostatic interactions with the anionic terminal groups, leading to contraction and a marked decrease in hydrocarbon hosting capacity. The present work highlights the robust nature of dendrimer oil dispersion and also illuminates potentially unintended or unanticipated effects of varying dendrimer surface chemistry on their encapsulation or hosting efficacy, which is important for their environmental, industrial, and biomedical applications.

show abstract

Section: Environmental Science and Technologymentioning

confidence: 99%

Structure–Function Relationship of PAMAM Dendrimers as Robust Oil Dispersants

Geitner

Wang

Andorfer

et al. 2014

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recent developments in the field of macromolecular science have opened gates to the synthesis of three-dimensional molecules with exceptional physico-chemical and mechanical properties. A class of these macromolecules-dendrimers-is highly branched, symmetrical and monodispersed with a well-defined number of end groups which can be functionalized to exhibit unique applications [30]. The vast flexibility in dendritic synthesis, rich physico-chemistry and selfassembly have inspired engineering of novel applications for gene and drug delivery.…”

Section: Protein Cage Template Nanoparticles For Catalysismentioning

confidence: 99%

Bioinspired nanoscale materials for biomedical and energy applications

Bhattacharya

Lin

2014

J. R. Soc. Interface.

Self Cite

View full text Add to dashboard Cite

The demand for green, affordable and environmentally sustainable materials has encouraged scientists in different fields to draw inspiration from nature in developing materials with unique properties such as miniaturization, hierarchical organization and adaptability. Together with the exceptional properties of nanomaterials, over the past century, the field of bioinspired nanomaterials has taken huge leaps. While on the one hand, the sophistication of hierarchical structures endows biological systems with multi-functionality, the synthetic control on the creation of nanomaterials enables the design of materials with specific functionalities. The aim of this review is to provide a comprehensive, up-to-date overview of the field of bioinspired nanomaterials, which we have broadly categorized into biotemplates and biomimics. We discuss the application of bioinspired nanomaterials as biotemplates in catalysis, nanomedicine, immunoassays and in energy, drawing attention to novel materials such as protein cages. Furthermore, the applications of bioinspired materials in tissue engineering and biomineralization are also discussed.

show abstract

“…Literature presents numerous reports on possible methods of using these macromolecules (Bhattacharya et al, 2013), among other things in biology or medicine Gor et al, 2014;Liu et al, 2014;Zhao et al, 2011). Dendrimer macromolecules can fulfil the function of supramolecular nanocarriers of low-molecular ligands: fragments of genetic material (Cao et al, 2013;Eichman et al, 2000;Jang et al, 2009;Pavan et al, 2010a,b;Peng et al, 2010;Shakhbazau et al, 2010;Wang et al, 2010), medical image contrasts (Tomalia et al, 2007) or drugs (Cheng and Xu, 2005;D'Emanuele and Attwood, 2005;Gupta et al, 2006;Kesharwani et al, 2014;Medina and El-Sayed, 2009;Najlah and D'Emanuele, 2006), including oncological drugs Kong et al, 2014;Sadekar et al, 2013;Thomas et al, 2010).…”

Section: Introductionmentioning

confidence: 99%