Exploration of Biomarkers for Asbestos Exposure and Occurrence of Malignant Mesothelioma Based on the Immunological Effects of Asbestos

Matsuzaki, Hidenori; Lee, Sai Peck; Takei-Kumagai, Naoko; Hayashi, Hiroaki; Miura, Yoshie; YingChen,; Maeda, Megumi; Yamamoto, Shoko; Hatayama, Tamayo; Nishimura, Yasumasa; Otsuki, Takemi

doi:10.4172/2153-0602.s2-001

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…It is well known that asbestos fibers can induce alterations in the immune system, while being involved in the inflammatory process 40 – 42 . Different studies have reported miR-197-3p as being significantly down-regulated in inflammatory conditions 43 .…”

Section: Discussionmentioning

confidence: 99%

Circulating microRNA-197-3p as a potential biomarker for asbestos exposure

Frontini

Bononi

Torreggiani

et al. 2021

Sci Rep

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Asbestos is considered the main cause of diseases in workers exposed to this mineral in the workplace as well as an environmental pollutant. The association between asbestos and the onset of different diseases has been reported, but asbestos exposure specific biomarkers are not known. MicroRNAs (miRNAs) are small, single-strand, non-coding RNAs, with potential value as diagnostic, prognostic, and predictive markers in liquid biopsies. Sera collected from workers ex-exposed to asbestos (WEA) fibers were compared with sera from healthy subjects (HS) of similar age, as liquid biopsies. The expression of the circulating miRNA 197-3p was investigated employing two different highly analytical PCR methods, i.e. RT-qPCR and ddPCR. MiR-197-3p levels were tested in sera from WEA compared to HS. MiR-197-3p tested dysregulated in sera from WEA (n = 75) compared to HS (n = 62). Indeed, miR-197-3p was found to be 2.6 times down-regulated in WEA vs. HS (p = 0.0001***). In addition, an inverse correlation was detected between miR-197-3p expression level and cumulative asbestos exposure, being this miRNA down-regulated 2.1 times in WEA, with high cumulative asbestos exposure, compared to WEA with low exposure (p = 0.0303*). Circulating miR-197-3p, found to be down regulated in sera from WEA, is proposed as a new potential biomarker of asbestos exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Circulating microRNA-197-3p as a potential biomarker for asbestos exposure

Frontini

Bononi

Torreggiani

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…It is well known that asbestos fibers can induce alterations in the immune system, while being involved in the inflammatory process [40][41][42] . Different studies have reported miR-197-3p as being significantly down-regulated in inflammatory conditions 43 .…”

Section: Discussionmentioning

confidence: 99%

Circulating microRNA-197-3p as a potential biomarker for asbestos exposure

Frontini¹,

Bononi²,

Torreggiani³

et al. 2021

Preprint

View full text Add to dashboard Cite

Asbestos is considered the main cause of diseases in workers exposed to this mineral in the workplace as well as an environmental pollutant. The association between asbestos and the onset of different diseases has been reported, but asbestos exposure specific biomarkers are not known. MicroRNAs (miRNAs) are small, single-strand, non-coding RNAs, with potential value as diagnostic, prognostic, and predictive markers in liquid biopsies. Sera collected from workers ex-exposed to asbestos (WEA) fibers were compared with sera from healthy subjects (HS) of similar age, as liquid biopsies. The expression of the circulating miRNA 197-3p was investigated employing two different highly analytical PCR methods, i.e. RT-PCR and dd-PCR. MiR-197-3p levels were tested in sera from WEA compared to HS. MiR-197-3p tested dysregulated in sera from WEA (n=75) compared to HS (n=62). Indeed, miR-197-3p was found to be 2.6 times down-regulated in WEA vs. HS (p=0.0001***). In addition, an inverse correlation was detected between miR-197-3p expression level and cumulative asbestos exposure, being this miRNA down-regulated 2.1 times in WEA, with high cumulative asbestos exposure, compared to WEA with low exposure (p=0.0303*). Circulating miR-197-3p, found to be down regulated in sera from WEA, is proposed as a new potential biomarker of asbestos exposure.

show abstract

Exploration of Biomarkers for Asbestos Exposure and Occurrence of Malignant Mesothelioma Based on the Immunological Effects of Asbestos

Cited by 2 publications

References 56 publications

Circulating microRNA-197-3p as a potential biomarker for asbestos exposure

Circulating microRNA-197-3p as a potential biomarker for asbestos exposure

Circulating microRNA-197-3p as a potential biomarker for asbestos exposure

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