Exploration of Copper(II) Acetate Catalyzed Regioselective Ethoxylation of o-Haloanilides with Picolinamide as a Directing Group

Abstract

In present work, we have explored an efficient Cu-catalyzed Ullmann-type C-O coupling methodology of o-haloanilides. This method could regioselectively achieve 2-ethoxylation of 2-Br/I picolinamides in ethanol using Cu(OAc)2 as a convenient catalyst with picolinamide as the directing group and intramolecular ligand, which is characterized by additional ligand-free, good regioselectivity, and high yields.