Exploration of Pharmacological and Toxicological Properties of Aerial Parts of Blumea lacera, a Common Weed in Bangladesh

Kundu, Pritam; Debnath, Shovan Lal; Sadhu, Samir Kumar

doi:10.1016/j.ccmp.2022.100038

Cited by 12 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genotypic specificity is among the various factors that govern the variability of total phenolics and total flavonoids contents in plants [34,35] . The higher total flavonoid content found in this species is consistent with previous findings that reported that B. lacera contains more total flavonoids than total phenolics [36,37] . Moreover, several other species of the Blumea genus, such as Blumea lacineta , [38] Blumea eriantha , [39] and Blumea balsamifera , [40] contain higher concentrations of total flavonoids than total phenolics.…”

Section: Resultssupporting

confidence: 89%

“…[34,35] The higher total flavonoid content found in this species is consistent with previous findings that reported that B. lacera contains more total flavonoids than total phenolics. [36,37] Moreover, several other species of the Blumea genus, such as Blumea lacineta, [38] Blumea eriantha, [39] and Blumea balsamifera, [40] contain higher concentrations of total flavonoids than total phenolics. Methanol extract yielded the highest total bioactive compounds, followed by ethanol and water extract, indicating that extractive yield potentials depend on solvent types.…”

Section: B Lacera Phytochemical Profiles Total Phenolics and Flavonoi...mentioning

confidence: 99%

See 1 more Smart Citation

Polyphenols Profile and Enzyme Inhibitory Properties of Blumea lacera (Burm. f.) DC.: A Potential Candidate against Obesity, Aging, and Skin Disorder

Swaraz¹,

Sultana²,

Ahmed

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

Blumea lacera (Burm. f.) DC. is attracting scientific interest due to the diverse biological activities of its various parts and its use in folk medicine. The present study was undertaken to investigate the tissue-specific differential expression pattern of its total bioactive compounds. The study was further extended to whole plant phenolics profiling, in vitro enzyme inhibition activities, followed by in silico enzyme inhibition analysis to assess its potential as herbal medicine. The amount of total phenolics in different tissues was followed in decreasing order as old leaf, flower bud, root, young leaf, flower, old stem, and young stem, while that for the flavonoids was old leaf, root, young leaf, flower bud, flower, young stem, and old stem. This study identified rosmarinic acid, quercetin, and kaempferol in this plant for the first time. The solvent extracts demonstrated strong inhibition of lipase and tyrosinase activity, along with varying degrees of inhibition of acetylcholinesterase and butyrylcholinesterase activity. Among the detected compounds, ten displayed strong in silico binding affinities with the tested enzymes. The findings provide a new insight into further investigation of the medicinal potential of this species against obesity, neurological disorders, and aberrant skin color.

show abstract

Section: Resultssupporting

confidence: 89%

Section: B Lacera Phytochemical Profiles Total Phenolics and Flavonoi...mentioning

confidence: 99%

Polyphenols Profile and Enzyme Inhibitory Properties of Blumea lacera (Burm. f.) DC.: A Potential Candidate against Obesity, Aging, and Skin Disorder

Swaraz¹,

Sultana²,

Ahmed

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…To determine the toxic nature of SCE on living bodies, an acute test was conducted by the method described by Kundu et al [ 12 ]. Doses of SCE at 1000, 3000, and 5000 milligram/kilogram (mg/kg) body weight (bw) were prepared by dissolving the sample in 1% Tween 80 in distilled water and orally administered to the different mouse groups.…”

Section: Methodsmentioning

confidence: 99%

“…Castor oil-induced diarrheal method described by Kundu et al [ 12 ] was used to evaluate the antidiarrheal effect of SCE. Prepared solutions of SCE at 250 and 500 mg/kg and loperamide at 3 mg/kg bw doses were orally administered to specific mouse groups while the mice of the control groups were fed with 1% Tween 80 solution.…”

Section: Methodsmentioning

confidence: 99%

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Kundu

Debnath

Ahad

et al. 2023

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Sonneratia caseolaris (L.) is a common mangrove plant which has significant medicinal value in traditional medicine. Ethanol extract from the fruits of S. caseolaris (SCE) was used in this project to explore its different pharmacological effects considering its traditional usage. In the castor oil-induced diarrheal method, SCE significantly lengthened the latency of the first defecation period up to 95.8 and 119.4 min as well as lowering stool count by 43.3% and 64.4% at the doses of 250 and 500 mg/kg, respectively. In evaluating the neuropharmacological effect using the open-field model, a significant central nervous system (CNS) depressant nature was observed after a reduction in the no. of squares crossed by mice at various time intervals. In evaluating the blood coagulation effect, SCE significantly reduced blood clotting time at 5.86, 5.52, and 5.01 min at 25, 50, and 100 mg/ml doses, respectively. In the assessment of the anthelmintic effect, SCE significantly killed Paramphistomum cervi (P. cervi) where the death times of the nematodes were 40.3, 36.8, and 29.9 min at 12.5, 25, and 50 mg/ml doses, respectively. The extract showed a very poor cytotoxic effect in brine shrimp lethality bioassay. In molecular docking analysis, maslinic acid, oleanolic acid, luteolin, luteolin 7-O-β-glucoside, myricetin, ellagic acid, and R-nyasol showed the best binding affinities with the selected proteins which might be the credible reasons for eliciting pharmacological responses. Among these seven compounds, only luteolin 7-O-β-glucoside had two violations in Lipinski’s rule of five.

show abstract

“…Qualitative phytochemical screening of the SC extract was carried out according to the method described by Kundu et al [ 8 ]. These tests were conducted to determine the presence of different phytochemical groups.…”

Section: Methodsmentioning

confidence: 99%

Analgesic, Anti-inflammatory, Antipyretic, and In Silico Measurements of Sonneratia caseolaris (L.) Fruits from Sundarbans, Bangladesh

Kundu

Debnath

Devnath

et al. 2022

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Sonneratia caseolaris is a widely distributed mangrove plant having much therapeutic importance in traditional medicine. This plant is reported for possessing numerous compounds that are already used for many therapeutic purposes. After finding the presence of antioxidant components in the qualitative antioxidative assay, we went to conduct quantitative tests where the total contents of phenolics, flavonoids, and tannins were estimated as 122 mg GAE/gm, 613 mg QE/gm, and 30 mg GAE/gm, respectively. In DPPH free radical, H2O2, and superoxide radical scavenging assay, the SC50 values were found to be 87, 66, and 192 μg/ml, respectively. In FeCl3 reducing power assay, the RC50 of SC extract and ascorbic acid were 80 and 28 μg/ml, respectively. This extract revealed a significant peripheral analgesic effect in the acetic acid-induced writhing model in mice by reducing the writhing impulse by about 21% and 39% at 250 and 500 mg/kg doses, respectively, and a central analgesic effect in the tail immersion method by elongating the time up to about 22% and 37% at the same doses. In the anti-inflammatory test in mice, this extract reduced the paw edema size over the observed period in a dose-dependent manner. It also showed a significant reduction in the elevated rectal temperature of mice in the observing period in Brewer’s yeast-induced pyrexia model. In silico analysis revealed better binding characteristics of ellagic acid and luteolin among other compounds with various receptors that might be responsible for antioxidative and anti-inflammatory properties. From our observation, we suppose that SC fruits might be a potential source of drug leads for various inflammatory disorders.

show abstract

Exploration of Pharmacological and Toxicological Properties of Aerial Parts of Blumea lacera, a Common Weed in Bangladesh

Cited by 12 publications

References 28 publications

Polyphenols Profile and Enzyme Inhibitory Properties of Blumea lacera (Burm. f.) DC.: A Potential Candidate against Obesity, Aging, and Skin Disorder

Polyphenols Profile and Enzyme Inhibitory Properties of Blumea lacera (Burm. f.) DC.: A Potential Candidate against Obesity, Aging, and Skin Disorder

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Analgesic, Anti-inflammatory, Antipyretic, and In Silico Measurements of Sonneratia caseolaris (L.) Fruits from Sundarbans, Bangladesh

Contact Info

Product

Resources

About