Exploration of pro-oxidant and antioxidant activities of the flavonoid myricetin

Chobot, Vladimı́r; Hadaček, Franz

doi:10.1179/1351000211y.0000000015

Cited by 99 publications

(69 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…29 Highest chelating activity in S. cumini with maximum number of flavonoids supports this view. S. cumini also contained all the phenols correlated with different activities.…”

Section: Discussionsupporting

confidence: 68%

Analysis of Antioxidant Activities, Phenolic and Other Metabolites of Some Biomass Waste (Leaves) of India

Begum

Banerjee²,

2018

FRA

View full text Add to dashboard Cite

Background:Antioxidants have important role on human health as well as in food industry. Natural antioxidants are preferred to synthetic antioxidants. Objective: In this study attempt was made to explore the leaf biomass, generally wasted and burnt, as sources of important antioxidant compounds. Methods: Extracts of leaves from five plants e.g. Artocarpus heterophyllus, Haldina cordifolia, Magnolia champaca, Mimusops elengi and Syzygium cumini were analyzed for their antioxidant properties by four different systems of assays. Identification and quantification of important components were performed using GC-MS. Results: All the extracts scavenged DPPH radical, superoxide radical, and chelated metal. S. cumini showed strongest antioxidant activities in all systems of assays. Many important phenols and other metabolites were identified. Correlation between activity and metabolite profile helped to identify important antioxidant compounds in the extracts. Important phenolic antioxidants identified were catechin, epicatechin, protocatechuic acid (from S. cumini), gallic acid, myricetin (from S. cumini, M. elengi), arbutin, 4-hydroxycinnamic acid (from M. elengi). Conclusion: Thus, the leaf biomass may be used as an alternative source of these important phytochemicals having antioxidant activity. Key words: Antioxidants, GC-MS, Leaf waste, Phytochemicals.Key message: Extracts of biomass waste (leaves) from five plants e.g. Artocarpus heterophyllus, Haldina cordifolia, Magnolia champaca, Mimusops elengi and Syzygium cumini showed antioxidant activities against free radicals and chelated metals. The extracts were found to be sources of important phenolic phytochemicals e.g. catechin, epicatechin, protocatechuic acid (from S. cumini), gallic acid, myricetin (from S. cumini, M. elengi), arbutin, 4-hydroxycinnamic acid (from M. elengi) having antioxidant activities.

show abstract

“…29 Highest chelating activity in S. cumini with maximum number of flavonoids supports this view. S. cumini also contained all the phenols correlated with different activities.…”

Section: Discussionsupporting

confidence: 68%

Analysis of Antioxidant Activities, Phenolic and Other Metabolites of Some Biomass Waste (Leaves) of India

Begum

Banerjee²,

2018

FRA

View full text Add to dashboard Cite

show abstract

“…Many plant secondary metabolites act as antioxidants and can affect ROS concentrations (Chobot and Hadacek, 2011). Flavonoids are an important group of plant secondary metabolites that perform as antioxidants (Nakabayashi et al, 2014; Nguyen et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

ALA-Induced Flavonols Accumulation in Guard Cells Is Involved in Scavenging H2O2 and Inhibiting Stomatal Closure in Arabidopsis Cotyledons

Feng

Liu

et al. 2016

Front. Plant Sci.

View full text Add to dashboard Cite

5-aminolevulinic acid (ALA), a new plant growth regulator, can inhibit stomatal closure by reducing H2O2 accumulation in guard cells. Flavonols are a main kind of flavonoids and have been proposed as H2O2 scavengers in guard cells. 5-aminolevulinic acid can significantly improve flavonoids accumulation in plants. However, whether ALA increases flavonols content in guard cells and the role of flavonols in ALA-regulated stomatal movement remains unclear. In this study, we first demonstrated that ALA pretreatment inhibited ABA-induced stomatal closure by reducing H2O2 accumulation in guard cells of Arabidopsis seedlings. This result confirms the inhibitory effect of ALA on stomatal closure and the important role of decreased H2O2 accumulation in this process. We also found that ALA significantly improved flavonols accumulation in guard cells using a flavonol-specific dye. Furthermore, using exogenous quercetin and kaempferol, two major components of flavonols in Arabidopsis leaves, we showed that flavonols accumulation inhibited ABA-induced stomatal movement by suppressing H2O2 in guard cells. Finally, we showed that the inhibitory effect of ALA on ABA-induced stomatal closure was largely impaired in flavonoid-deficient transparent testa4 (tt4) mutant. In addition, exogenous flavonols recovered stomatal responses of tt4 to the wild-type levels. Taken together, we conclude that ALA-induced flavonol accumulation in guard cells is partially involved in the inhibitory effect of ALA on ABA-induced H2O2 accumulation and stomatal closure. Our data provide direct evidence that ALA can regulate stomatal movement by improving flavonols accumulation, revealing new insights into guard cell signaling.

show abstract

“…So far, a catechol ( o- dihydroxy) or pyrogallol (trihydroxy) arrangement on ring B is regarded as essential for antioxidant activity because the required energy for their dissociation is lower compared to that of other hydroxyl groups on ring A or C [6]. The flavonoids with the catechol or pyrogallol moieties may also show pro-oxidant effects in some reaction conditions [7,8]. A 2,3-double bond in ring C further increases the antioxidant effects of ring B hydroxyl groups [3] by extending electron dislocation [4].…”

Section: Introductionmentioning

confidence: 99%

Pro- and Antioxidant Activity of Three Selected Flavan Type Flavonoids: Catechin, Eriodictyol and Taxifolin

Chobot

Hadaček

Bachmann

et al. 2016

IJMS

Self Cite

View full text Add to dashboard Cite

The flavanol (±)-catechin shows an OH group but no 4-keto group on ring C (C3), and no conjugation between ring A and B. The related flavanone (+)-eriodictyol has a keto group on C4 but no 3-OH group on ring C. (+)-Taxifolin, another flavanone, has an OH on C3 and a keto group on C4 of the C ring. Deoxyribose degradation assay systems, with hydrogen peroxide and ascorbic acid either added or omitted, were performed in variants in which Fe(III) was added in a complex with ethylenediaminetetraacetic acid (EDTA). In combination with differential pulse voltammetry (DVP), the specific redox-chemical contributions of the ring A m-dihydroxyl groups could be explored more specifically in addition to those of the traditionally investigated o-dihydroxyl groups of ring B.

show abstract

Exploration of pro-oxidant and antioxidant activities of the flavonoid myricetin

Cited by 99 publications

References 33 publications

Analysis of Antioxidant Activities, Phenolic and Other Metabolites of Some Biomass Waste (Leaves) of India

Analysis of Antioxidant Activities, Phenolic and Other Metabolites of Some Biomass Waste (Leaves) of India

ALA-Induced Flavonols Accumulation in Guard Cells Is Involved in Scavenging H2O2 and Inhibiting Stomatal Closure in Arabidopsis Cotyledons

Pro- and Antioxidant Activity of Three Selected Flavan Type Flavonoids: Catechin, Eriodictyol and Taxifolin

Contact Info

Product

Resources

About