Exploration of the Chemistry and Biological Properties of Pyrimidine as a Privilege Pharmacophore in Therapeutics

Abstract

The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin B1. Due to its prebiotic nature to living cells in biodiversity, it is an highly privileged motif for the development of molecules of biological and pharmaceutical interest. This present work deals with the exploration of chemistry and medicinal diversity of pyrimidine which might pave way to long await discovery in therapeutic medicine for future drug design.

Facile Synthesis, Characterization and Antimicrobial Activity of 2-Alkanamino Benzimidazole Derivatives

“…Over the years, the heterocyclic compounds have attracted numerous attentions due to their wide applications in medicinal chemistry research 1 . Nitrogen-containing heterocyclic compounds have been prominent even in early studies of chemistr y. Benzimidazole is a benzo-fused imidazole which constitutes an important class of heterocyclic compound in numerous natural and synthetic compounds in medicinal chemistry for new drug development 2 .…”

Expeditious Synthesis and Spectroscopic Characterization of 2-Methyl-3-substituted-quinazolin-4(3H)-one Derivatives

“…Hence, in the continuation of our effort on the synthesis of N-heterocyclic motifs 1,2,4 , we have herein achieved expeditious synthesis of 2-methyl-3-substituted quinazoline-4(3H)-one derivatives 8a-q, in a two steps technique. The first step of the synthesis in this present research work, involved the reaction of anthranilic acid with acetic anhydride according to a known procedure reported by Hassan et al 22 .…”

“…Also, most marketed drugs constitute of common structural units of heterocyclic compounds which could also be useful in the synthesis of biologically active agrochemicals 2,3 . For instance, in the pharmaceutical industry, among the top two hundred branded drugs, we have more than 75% of them which have heterocyclic fragments in their structures 4 . One of these organic compounds of interest among the heterocycles is quinazoline otherwise known as 1,3-diazanaphthalene, benzo-1,3-diazine, benzopyrimidine which was first synthesized by Gabriel in 1903 5 .…”

Synthesis of chloro, fluoro, and nitro derivatives of 7‐amino‐5‐aryl‐6‐cyano‐5H‐pyrano pyrimidin‐2,4‐diones using organic catalysts and their antimicrobial and anticancer activities

“…Pyrimidines and its analogues are an important class of heterocyclic compounds, and their structural skeleton is a key constituent of nucleic acids, alkaloids, and numerous other pharmacophores with a variety of potent biological activities . Pyrano[2,3‐ d ]pyrimidines consists of a pyran ring fused together with pyrimidine.…”