Exploration of the early insulin response by two small successive loads of I.V. glucose in normal and obese subjects

Abstract

Two 5 g glucose loads at 1-h interval were given to healthy controls and obese subjects with slightly altered or normal OGTT in order to explore the capacity of restoration of the "rapid insulin response" to i.v. glucose. In the normal subjects, the two successive loads gave rise to identical responses as far as maximum increase (delta max), average increase at 2-5 min (delta 2-5 min), area of increase 0-15 min (delta 0-15 min) for both glucose and IRI, were concerned. Obese subjects could be divided on the basis of their insulin response to the first load into normal responders (group I) and high-responders (group II). In group I obese subjects, the responses to the second load were identical to those to the first. In group II obese subjects delta max, delta 2-5 min and delta 0-15 min of the insulin response to the second load were reduced as compared to the first.

Effects of Pioglitazone on Insulin Sensitivity and Serum Lipids in Obese Cats

“…An interesting feature of the postpioglitazone NEFA profiles in the obese cats was the brisk suprabasal rebound that followed initial suppression. In humans, this has been attributed to lipolytic hormone release secondary to rapid glucose clearance, 26 and is faster in lean than in obese individuals. 27 A similar phenomenon has been described after pharmacological doses of glucose administered PO, and the magnitude of the NEFA rebound in one study was positively correlated with insulin sensitivity.…”