Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in cervical cancer

Yao, Tingting; Rao, Qunxian; Liu, Longyang; Zheng, Chengyu; Xie, Qingsheng; Liang, Jinxiao; Lin, Zhongqiu

doi:10.1186/1743-422x-10-175

Cited by 53 publications

(48 citation statements)

References 27 publications

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“…Li et al () revealed that knockdown of miR‐641 inhibited the proliferation, migration, and invasion of ovarian cancer cells by regulating the p63/miR200 axis. The previous study showed an increased expression of miR‐641 in CC (Yao et al, ) but the effects of miR‐641 dysregulation in CC was unclear. In this study, we found that miR‐641 expression was significantly increased in CC tissues, and knockdown of miR‐641 could inhibit the invasion and migration of CC cells.…”

Section: Discussionmentioning

confidence: 95%

LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis

Zhu

Liu

Zhang

et al. 2019

Cell Biology International

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Cervical cancer (CC) is the fourth leading cause of cancer‐related death in women worldwide. There is an urgent need to find novel targets for the treatment of CC. Recently, microRNA have emerged as critical factors in tumorigenesis. In this study, we aimed to investigate the mechanism of miR‐641 on the migration and invasion of CC cells. In silico analysis revealed putative interaction between miR‐641 and phosphatase and tensin homolog (PTEN) RNA/lncRNA tumor suppressor candidate 8 (TUSC8). Hence we evaluated the expression of TUSC8, miR‐641, and PTEN. We found that the expressions of TUSC8 and PTEN were decreased in CC tissues, whereas miR‐641 expression was increased. Inhibition of miR‐641 suppressed the migration and invasion of Hela cells. In addition, TUSC8 and PTEN were upstream and downstream target molecule of miR‐641, respectively. Overexpression of TUSC8 promoted PTEN expression, and suppressed the invasion and migration of Hela cells, whereas miR‐641 mimic treatment changed the effects. These results demonstrated that overexpression of TUSC8 could inhibit the invasion and migration of CC cells by upregulating PTEN via miR‐641.

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Section: Discussionmentioning

confidence: 95%

LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis

Zhu

Liu

Zhang

et al. 2019

Cell Biology International

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“…Recently, a study found that miRNA pairs could predict which lesions would progress to SCCC. Recent work in the miRNA field has focused on epigenetic changes that affect miRNA expression in the progression of CIN to invasive disease using human tissue samples and treated in vitro cultures [125]. Importantly, one of the miRNAs that was found to be regulated by methylation and important for higher grade lesion, miR-124 [123], has been under testing for a quantitative methylation-specific PCR assay on Pap specimens [124].…”

Section: The Role Of Mirnas In Initiating Lesions To Squamous-cell Cementioning

confidence: 99%

Role of microRNAs in cancers of the female reproductive tract: insights from recent clinical and experimental discovery studies

Logan

Hawkins

2014

Clinical Science

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microRNAs (miRNAs) are small RNA molecules that represent the top of the pyramid of many tumorigenesis cascade pathways as they have the ability to affect multiple, intricate, and still undiscovered downstream targets. Understanding how miRNA molecules serve as master regulators in these important networks involved in cancer initiation and progression open up significant innovative areas for therapy and diagnosis that have been sadly lacking for deadly female reproductive tract cancers. This review will highlight the recent advances in the field of miRNAs in epithelial ovarian cancer, endometrioid endometrial cancer and squamous-cell cervical carcinoma focusing on studies associated with actual clinical information in humans. Importantly, recent miRNA profiling studies have included well-characterized clinical specimens of female reproductive tract cancers, allowing for studies correlating miRNA expression with clinical outcomes. This review will summarize the current thoughts on the role of miRNA processing in unique miRNA species present in these cancers. In addition, this review will focus on current data regarding miRNA molecules as unique biomarkers associated with clinically significant outcomes such as overall survival and chemotherapy resistance. We will also discuss why specific miRNA molecules are not recapitulated across multiple studies of the same cancer type. Although the mechanistic contributions of miRNA molecules to these clinical phenomena have been confirmed using in vitro and pre-clinical mouse model systems, these studies are truly only the beginning of our understanding of the roles miRNAs play in cancers of the female reproductive tract. This review will also highlight useful areas for future research regarding miRNAs as therapeutic targets in cancers of the female reproductive tract.

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“…in cervical cancers has been linked to increased promoter methylation of respective genes 73,74,83,84 . These data are fully in line with the concept that an increase in specific genetic and epigenetic alterations reflects a longer duration of existence of the underlying lesion.…”

Section: Mir-124-2 Hsa-mir-124-3 Hsa-mir-149 Hsa-mir-203 Hsa-mir-mentioning

confidence: 99%

Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions

et al. 2014

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PrefaceInfection of cervical epithelium with high-risk human papillomavirus (hrHPV) might result in productive or transforming cervical intraepithelial neoplasia (CIN) lesions, the morphology of which can overlap. In transforming CIN lesions aberrations in host cell genes accumulate over time, which is necessary for ultimate progression to cancer. On the basis of (epi)genetic changes, early and advanced transforming CIN lesions can be distinguished. This paves the way for new molecular tools for cervical screening, diagnosis and management of cervical cancer precursor lesions.

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Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in cervical cancer

Cited by 53 publications

References 27 publications

LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis

LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis

Role of microRNAs in cancers of the female reproductive tract: insights from recent clinical and experimental discovery studies

Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions

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