LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis

Zhu, Yanling; Liu, Beibei; Zhang, Ping; Zhang, Jie; Wang, Lan

doi:10.1002/cbin.11152

Cited by 30 publications

(24 citation statements)

References 23 publications

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“…lncRNA RP4 suppresses the development of colorectal cancer by acting as a sponge for miR-7-5p (8). It is worth noting that TUSc8 plays an anti-oncogenic role in cervical cancer by sponging miR-641 (14). Moreover, a recent study indicated that TUSc8 functions as a ceRNA of MYLIP by competitively binding with miR-190b-5p to inhibit breast cancer growth (36).…”

Section: Discussionmentioning

confidence: 99%

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TUSC8 inhibits the development of osteosarcoma by sponging miR‑197‑3p and targeting EHD2

et al. 2020

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Osteosarcoma (OS) is one of the most common malignant bone tumours and generally occurs in children and adolescents. Increasing evidence has demonstrated that dysregulated long non-coding RNAs (lncRNAs) play crucial roles in the progression of various human neoplasms. Among these, tumour suppressor candidate 8 (TUSc8) is a novel lncRNA and has been reported to function as a tumour suppressor in cervical cancer. However, the exact role of TUSc8 in OS remains largely unknown. In the present study, it was observed that TUSc8 was markedly downregulated in OS tissues and cell lines. Functional experiments demonstrated that the overexpression of TUSC8 significantly suppressed the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), whereas it accelerated the apoptosis of OS cells. Mechanistically, TUSc8 served as a sponge for miR-197-3p, and EH-domain containing 2 (EHd2) was identified as a downstream target molecule of miR-197-3p. Further investigations indicated that EHD2 knockdown significantly reversed the effects on OS cellular processes induced by TUSC8 overexpression. On the whole, these findings indicate that TUSc8 functions as a competing endogenous RNA (ceRNA) to suppress OS cell growth and EMT via the miR-197-3p/EHd2 axis. TUSc8 may thus function as a potential therapeutic target in OS treatment.

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Section: Discussionmentioning

confidence: 99%

“…TUG1 knockdown also suppresses OS cell proliferation and invasion via miR-153 (13). Indeed, recent evidence has revealed that TUSc8 serves as a tumour suppressor in the development of cervical cancer by regulating the miR-641/PTEN pathway (14). However, as a novel lncRNA, the specific role of TUSC8 in OS has not yet been clarified.…”

Section: Introductionmentioning

confidence: 99%

TUSC8 inhibits the development of osteosarcoma by sponging miR‑197‑3p and targeting EHD2

et al. 2020

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“…Among them, lncRNA, as a ceRNA, plays an important role in the development of cervical cancer by sponging miRNA to regulate expression of genes. For example, lncRNA TUSC8 can upregulate the expression of PTEN by sponging miR-641, thereby inhibiting the invasion and migration of cervical cancer cells [31]. LncRNA MIR205HG can act as a ceRNA to promote the proliferation and migration of cervical cancer cells by reversing the inhibitory effect of miR-122-5p on FOXP2 [32].…”

Section: Discussionmentioning

confidence: 99%

LncRNA CAR10 Upregulates PDPK1 to Promote Cervical Cancer Development by Sponging miR-125b-5p

Zhang

Gao

2020

BioMed Research International

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Cervical cancer is one of the malignant tumors that seriously threaten women’s health. The mechanism of development needs to be deeply studied. In recent years, lncRNA has been identified as one of the important factors affecting the malignant progression of tumors. In this study, we illustrated the important mechanism of lncRNA CAR10 in the development of cervical cancer. We found that CAR10 is significantly increased in4 cervical cancer tissues and cells, which can promote the proliferation of cervical cancer cells in vitro and in vivo, indicating that CAR10 is involved in the progression of cervical cancer as an oncogene. Further studies showed that CAR10 is a target gene of miR-125b-5p, and miR-125b-5p can inhibit the effect of CAR10 on the proliferation of cervical cancer cells. In addition, we also found that 3-phosphoinositide-dependent protein kinase 1 (PDPK1) is also a target gene of miR-125b-5p, and CAR10 can upregulate the expression level of PDPK1. The results showed that CAR10 acts as a ceRNA to upregulate the expression of PDPK1 by sponging miR-125b-5p. Knockdown of PDPK1 can inhibit the effect of CAR10 on cervical cancer cells. Our study demonstrates that, based on ceRNA mechanism, CAR10/miR-125b-5p/PDPK1 network can regulate the proliferation of cervical cancer cells and play an important role in the development of cervical cancer. In addition, our study also suggests that intervention of CAR10/miR-125b-5p/PDPK1 network may be a new strategy for targeted therapy of cervical cancer.

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“…According to previous studies, several lncRNAs have been reported to be involved in the progression of CC. lncRNA TUSC8 plays an important role in inhibiting the invasion and migration of CC cells via miR-641/PTEN axis (9). lncRNA MIR205HG acts as a competing endogenous RNA (ceRNA) and modulates tumor growth and progression via sponging miR-122-5p in CC (10).…”

Section: Introductionmentioning

confidence: 99%

lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer

Song

Wang

Pan

et al. 2020

Braz J Med Biol Res

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Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is one kind of cytoplasmic long non-coding RNA (lncRNA), which has been demonstrated to play a critical function in multiple cancers. However, the detailed mechanism of OIP5-AS1 in the regulation of cervical cancer progression is still obscure. Here, we demonstrated that lncRNA OIP5-AS1 was upregulated in cervical cancer and was correlated with poor prognosis by bioinformatics studies. OIP5-AS1 depletion inhibited cell proliferation and promoted cell apoptosis in cervical cancer cells. Furthermore, we clarified that ROCK1 was the downstream effector of OIP5-AS1 and OIP5-AS1 acted as a molecular sponge of miR-143-3p. Finally, we verified that OIP5-AS1 exerted its function in the regulation of cervical cancer progression via interacting with miR-143-3p to regulate ROCK1 expression. Our study revealed novel mechanisms about how lncRNA OIP5-AS1 executed its function in cervical cancer and thus provided potential therapeutic targets for the disease.

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LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis

Cited by 30 publications

References 23 publications

TUSC8 inhibits the development of osteosarcoma by sponging miR‑197‑3p and targeting EHD2

TUSC8 inhibits the development of osteosarcoma by sponging miR‑197‑3p and targeting EHD2

LncRNA CAR10 Upregulates PDPK1 to Promote Cervical Cancer Development by Sponging miR-125b-5p

lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer

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