Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults

McCann, A.; Jeffery, Ian B.; Ouliass, Bouchra; Ferland, Guylaine; Fu, Xueyen; Booth, Sarah L.; Tran, Tam; O’Toole, Paul W.; O’Connor, Eibhlís M.

doi:10.1093/ajcn/nqz220

Cited by 32 publications

(35 citation statements)

References 63 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recently published study, McCann et al explored the association between gut microbiota-derived vitamin K and cognitive function [115]. Indeed, vitamin K has protective effects on myelin integrity and has been found to be reduced in AD patients.…”

Section: The Role Of Microbiome In Prion and Alzheimer’s Diseasementioning

confidence: 99%

“…Since some commensal bacteria are able to produce vitamin K, this may be a mechanism though which microbial dysbiosis may exert pathogenic effects. Interestingly, by correlating the gut metagenomes of the elderly with their different cognitive levels, some vitamin K isoforms were identified as positively correlated with cognition [115].…”

Section: The Role Of Microbiome In Prion and Alzheimer’s Diseasementioning

confidence: 99%

See 1 more Smart Citation

Microbiome Influence in the Pathogenesis of Prion and Alzheimer’s Diseases

D’Argenio

Sarnataro

2019

IJMS

View full text Add to dashboard Cite

Misfolded and abnormal β-sheets forms of wild-type proteins, such as cellular prion protein (PrPC) and amyloid beta (Aβ), are believed to be the vectors of neurodegenerative diseases, prion and Alzheimer’s disease (AD), respectively. Increasing evidence highlights the “prion-like” seeding of protein aggregates as a mechanism for pathological spread in AD, tauopathy, as well as in other neurodegenerative diseases, such as Parkinson’s. Mutations in both PrPC and Aβ precursor protein (APP), have been associated with the pathogenesis of these fatal disorders with clear evidence for their pathogenic significance. In addition, a critical role for the gut microbiota is emerging; indeed, as a consequence of gut–brain axis alterations, the gut microbiota has been involved in the regulation of Aβ production in AD and, through the microglial inflammation, in the amyloid fibril formation, in prion diseases. Here, we aim to review the role of microbiome (“the other human genome”) alterations in AD and prion disease pathogenesis.

show abstract

Section: The Role Of Microbiome In Prion and Alzheimer’s Diseasementioning

confidence: 99%

Section: The Role Of Microbiome In Prion and Alzheimer’s Diseasementioning

confidence: 99%

Microbiome Influence in the Pathogenesis of Prion and Alzheimer’s Diseases

D’Argenio

Sarnataro

2019

IJMS

View full text Add to dashboard Cite

show abstract

“…In the gut, the microbes can synthesize vitamin K and B vitamins along with their precursors (Rodionov et al, 2019 ). There are reports that at least some of the vitamins are accessible to the host (LeBlanc et al, 2013 ) and their fecal concentrations can be associated with clinical factors (McCann et al, 2019 ). Recent studies indicate that the importance of gut as a source of vitamins is limited and even a greater role of these vitamins might be in maintaining a robust ecological network between the species in the gut (Rodionov et al, 2019 ; Sharma et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolic Phenotypes as Potential Biomarkers for Linking Gut Microbiome With Inflammatory Bowel Diseases

Iablokov

Klimenko

Efimova³

et al. 2021

Front. Mol. Biosci.

View full text Add to dashboard Cite

The gut microbiome is of utmost importance to human health. While a healthy microbiome can be represented by a variety of structures, its functional capacity appears to be more important. Gene content of the community can be assessed by “shotgun” metagenomics, but this approach is still too expensive. High-throughput amplicon-based surveys are a method of choice for large-scale surveys of links between microbiome, diseases, and diet, but the algorithms for predicting functional composition need to be improved to achieve good precision. Here we show how feature engineering based on microbial phenotypes, an advanced method for functional prediction from 16S rRNA sequencing data, improves identification of alterations of the gut microbiome linked to the disease. We processed a large collection of published gut microbial datasets of inflammatory bowel disease (IBD) patients to derive their community phenotype indices (CPI)—high-precision semiquantitative profiles aggregating metabolic potential of the community members based on genome-wide metabolic reconstructions. The list of selected metabolic functions included metabolism of short-chain fatty acids, vitamins, and carbohydrates. The machine-learning approach based on microbial phenotypes allows us to distinguish the microbiome profiles of healthy controls from patients with Crohn's disease and from ones with ulcerative colitis. The classifiers were comparable in quality to conventional taxonomy-based classifiers but provided new findings giving insights into possible mechanisms of pathogenesis. Feature-wise partial dependence plot (PDP) analysis of contribution to the classification result revealed a diversity of patterns. These observations suggest a constructive basis for defining functional homeostasis of the healthy human gut microbiome. The developed features are promising interpretable candidate biomarkers for assessing microbiome contribution to disease risk for the purposes of personalized medicine and clinical trials.

show abstract

“…It is generally considered that the microbial synthesis of K2 in the equine hindgut is an available source of the vitamin but evidence to the significance of this source is lacking. There is increasing evidence to suggest that microbial synthesis may not be as important to overall vitamin K status as previously thought (Skinner et al 2015). McCann et al (2019 found that while vitamin K2 is produced by gut bacteria, the mechanisms by which absorption occurs from the colon in humans are unknown (Karl et al 2017).…”

Section: Vitamin K Metabolismmentioning

confidence: 89%

“…There is no consensus on the importance vitamin K2 to the vitamin economy of a human or animal host (McCann et al 2019)(McCann et al 2015, and this is discussed further in the next section. Moreover, little attention has been given to vitamin K concentrations of animal feedstuffs, because of the lack of bleeding conditions in livestock and the availability of menadione as an animal feed additive.…”

Section: Figure 21: the Different Forms Of Vitamin K; (A) K3 (B) K1mentioning

confidence: 99%

Vitamin K and equine osteocalcin: an enigma explored

Skinner¹

View full text Add to dashboard Cite

Vitamin K has received considerably less attention over the past 50 years compared to other fat soluble vitamins. Intakes of vitamin K beyond that required for normal blood coagulation were believed to confer no additional benefits, and therefore rarely investigated. The requirements and physiological role of vitamin K appeared to be secure. This view of vitamin K has changed recently following the delineation of its cofactor role in protein carboxylation, and the growing awareness of its interactions with other essential metabolic functions, beyond that of blood coagulation; there is much to be discovered. At present, seventeen vitamin Kdependent proteins (VKDPs) have been characterised, but the functionality of some still remains to be elucidated. Vitamin K has recently been implicated in osteoarthritis and accumulating evidence from human studies supports a protective role for vitamin K. To date however, little research into the role vitamin K may play in equine bone development exists. Developmental orthopaedic disease (DOD) is a term that encompasses a number of bone related conditions in the horse. It is a significant cause of lameness and wastage in a number of breeds, in particular Thoroughbreds and Warmbloods. It has clinical features in common with that of osteoporosis and osteoarthritis in the elderly. The VKDP osteocalcin is one of the few that has been extensively studied in humans and rodents. Located within bone, this protein plays a vital role in bone metabolism, facilitating the binding of bone minerals with protein. Decreased functionality of this protein has been found to be associated with increased fracture risk and osteoporosis in humans. The studies in this program were initiated to establish the relationship between vitamin K status and the development of DOD in foals. As bone development begins in utero, the first step was to examine placental transfer of the vitamin and then determine availability to the foal through milk. It was found in the initial experiments (Chapter 3), that foals at birth, had negligible concentrations of vitamin K1 (<0.01ng/mL) in both umbilical cord and foal plasma. The results clearly demonstrated that there is limited trans-placental transfer of vitamin K in the horse. It was also shown that milk can be enriched with vitamin K by supplementation of the mare with the vitamin. These studies confirmed that plasma concentrations were not a reliable measure of overall vitamin K status. Circulating osteocalcin and, its carboxylation status, has been proposed as one of the indicators of vitamin K status and a 'biomarker' of bone metabolism. Current assays available to measure Publications included in this thesis "No publications included". v

show abstract

Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults

Cited by 32 publications

References 63 publications

Microbiome Influence in the Pathogenesis of Prion and Alzheimer’s Diseases

Microbiome Influence in the Pathogenesis of Prion and Alzheimer’s Diseases

Metabolic Phenotypes as Potential Biomarkers for Linking Gut Microbiome With Inflammatory Bowel Diseases

Vitamin K and equine osteocalcin: an enigma explored

Contact Info

Product

Resources

About