Explore the multitarget mechanism of tetrahydrocurcumin preventing on UV-induced photoaging mouse skin

The role of tetrahydrocurcumin in disease prevention and treatment

“…THC improved UV-induced skin photoaging in mice by anti-inflammatory and antioxidant activities, regulating extracellular matrix and reducing melanin production. 23,24 Most cutaneous squamous cell carcinoma results from an actinic keratosis. THC inhibited keratinocyte growth by activating p38 MAPK and had potential to treat hyperproliferative epidermal disorders.…”

“…Numerous studies have shown that THC has great potential in a variety of diseases, including neurological diseases, cardiovascular system diseases, kidney diseases and cancer. Our research group also conducted a multidimensional evaluation of THC through animal studies and found that THC had potential therapeutic effects in cognitive impairment, 20,21 breast cancer, 22 skin photoaging, 23,24 melanin production, 25 type 2 diabetes, 26,27 colon cancer, 28 high-altitude cerebral oedema. 29 In addition, solid dispersion of THC was prepared, which effectively improved its bioavailability 30 and we further valuated its effect on metabolic syndrome, 31,32 Alzheimer's disease (AD) through animal experiments.…”

Biocompatible and bioactive hydrogels of recombinant fusion elastin with low transition temperature for improved healing of UV-irradiated skin

“…1 Currently, many drugs are developed to treat ultraviolet skin damage, such as nonsteroidal anti-inflammatory drugs, 2 tretinoin, 3 and diferuloylmethane. 4 However, their therapeutic effects have drawbacks of phototoxicity, adverse reactions, and drug resistance. Therefore, there is an urgent need to develop a more efficient and biocompatible photodamaged skin repair material.…”

Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions

“…Tetrahydrocurcumin (THC), a polyphenolic compound, is the main metabolite of curcumin (Yu et al., 2023 ). THC demonstrates curcumin-like therapeutic activities, with superior antioxidant (Gao et al., 2022 ), anti-inflammatory (Lin et al., 2022 ), anti-diabetic (Tsai et al., 2021 ), and anti-aging effects (Xu et al., 2022 ). Additionally, it is a chemopreventive agent against various malignancies (Lai et al., 2020 ; Tang et al., 2021 ).…”