Exploring Anti-Fungal, Anti-Microbial and Anti-Inflammatory Properties of a Topical Non-Steroidal Barrier Cream in Face and Chest Seborrheic Dermatitis

Balato, Anna; Caiazzo, Giuseppina; Caprio, Roberta Di; Scala, Emanuele; Fabbrocini, Gabriella; Granger, Corinne

doi:10.1007/s13555-019-00339-w

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Finally, zinc‐PCA is a inorganic well‐note compound that combines anti‐inflammatory, antimicrobial properties with antiseborrheic efficacy 15 . Of note, our microbiological results, although related to a limited number of patients, support the antifungal and antibacterial properties of the product as reported by other authors 16,17 …”

Section: Discussionsupporting

confidence: 82%

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Treatment of cradle cap in infants with a new cosmetic non‐steroidal gel cream: Clinical, laboratory, and instrumental evaluation

Micali

Pulvirenti

Dall’Oglio

et al. 2021

J of Cosmetic Dermatology

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Background Cradle cap is a benign and self‐limiting variant of seborrheic dermatitis (SD) that can be distressing for parents. Aims To assess by clinical/laboratory/instrumental evaluation the efficacy/tolerability of a gel cream containing piroctone olamine (antifungal), biosaccharide gum‐2 (antifungal), stearyl glycyrrhetinate (anti‐inflammatory), and zinc l‐pyrrolidone carboxylate (zinc‐PCA) (antiseborrheic) in the treatment of mild/ moderate cradle cap. Methods In this prospective, open‐label trial, 10 infants, with mild/moderate cradle cap enrolled at the Dermatology University Clinic of Catania (Italy) used the tested gel cream twice daily for 30 days. Degree of erythema was evaluated clinically by a 5‐point severity scale (from 0=no erythema to 4=severe erythema), at baseline, at 15 and 30 days. Desquamation was rated by dermoscopy evaluation using a 5‐point scale (from 0=no desquamation to 4=severe/many large adherent white flakes), at all time points. An Investigator Global Assessment (IGA) using a 6‐point scale (from −1=worsening to 4=complete response/clear) was also performed at 30 days. Five subjects, randomly selected, underwent double microbiological evaluation for bacteria and yeasts by cultures of cotton swabs at baseline and at 30 days. Tolerability/acceptability was evaluated on a 4‐point scale (from 0=very poor to 3=excellent) at 15 and 30 days. Data were processed using SAS version 9. Results At baseline, a significant colony‐forming unit (CFU) count for Malassezia furfur and Staphylococcus aureus was detected in 4 out of 5 selected patients. After 15 and 30 days, a statically significant reduction from baseline in erythema and desquamation severity was observed, along with a reduction in CFU count for Malassezia furfur and Staphylococcus aureus from baseline. No signs of local side effects were documented. Conclusions Our results indicate that the tested gel cream may represent a valid option to treat mild‐to‐moderate forms of cradle cap and support its antifungal and antibacterial properties.

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Section: Discussionsupporting

confidence: 82%

“…15 Of note, our microbiological results, although related to a limited number of patients, support the antifungal and antibacterial properties of the product as reported by other authors. 16,17…”

Section: Discussionmentioning

confidence: 99%

Treatment of cradle cap in infants with a new cosmetic non‐steroidal gel cream: Clinical, laboratory, and instrumental evaluation

Micali

Pulvirenti

Dall’Oglio

et al. 2021

J of Cosmetic Dermatology

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“… 14 This topical treatment has previously been reported to accelerate recovery and prevent flare-ups. 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

Facial Seborrheic Dermatitis in HIV-Seropositive Patients: Evaluation of the Efficacy and Safety of a Non-Steroidal Cream Containing Piroctone Olamine, Biosaccharide Gum-2 and Stearyl Glycyrrhetinate – A Case Series

Cortés-Correa¹,

Piquero-Casals²,

Chaparro-Reyes³

et al. 2022

CCID

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Facial seborrheic dermatitis is common in HIV-positive patients, and the presence of facial lesions can affect quality of life. The management and control of lesions can be frustrating for both physicians and patients. In this pilot clinical study, we clinically evaluated the effectiveness of a topical non-steroidal cream in treating mild to moderate facial seborrheic dermatitis in 20 HIV-positive patients. The patients applied a twice-a-day topical cream containing zinc PCA, piroctone olamine, hydroxyphenyl propamidobenzoic acid, biosaccharide gum-2, and stearyl glycyrrhetinate for 12 weeks with no topical or oral antifungal or corticosteroid treatment. Signs and symptoms and tolerance were assessed before, during, and at the end of treatment. All of the patients showed clinical improvement after 4 and 12 weeks of treatment. None of the patients had no response to treatment, and no adverse effects were reported. No rescue therapy with corticosteroids was needed. The patients reported a very noticeable improvement in their skin which contributed to high compliance with the protocol requirement.

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Evaluating the Impact of Antifungal Drugs on Human Health and Exploring Alternative Treatments

Mandal

2024

Orient. J. Chem

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Fungi occurred naturally like Candida yeast, in the human body. It may grow on skin, inside the digestive system and vagina. Antifungal drugs are used to kill or stop this fungal growth. According to their mode of action they are divided into azoles (inhibit ergosterol synthesis), echinocandins (damage cell walls), and polyenes (destroy fungal cells) etc. Depending on the seriousness of infection and type of infection, generally antifungal drugs are administered to a body. Oral antifungals are taken by mouth for systemic infections. Topical antifungals (creams, ointments) treat localized skin and nail infections. Intravenous (IV) administration is used for severe cases. Common side effects of antifungals are yeast infection, hepatotoxicity, ringworm, nail and skin infections etc. Serious fungal infections pose a growing threat to human health specially for vulnerable patients having significant morbidity and mortality such as AIDS patients, transplant recipients, and individuals using certain medications. Some of the existing antifungal drugs, particularly azoles, are facing increasing resistance. In order to ensure successful treatment of these drug-resistant infections, there is a critical need for the development of novel antifungal agents which is very challenging. Here about the antifungals, its classification, pros and cons of using antifungal drugs, prevention and control of antifungals are discussed in detail.

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Exploring Anti-Fungal, Anti-Microbial and Anti-Inflammatory Properties of a Topical Non-Steroidal Barrier Cream in Face and Chest Seborrheic Dermatitis

Cited by 3 publications

References 33 publications

Treatment of cradle cap in infants with a new cosmetic non‐steroidal gel cream: Clinical, laboratory, and instrumental evaluation

Treatment of cradle cap in infants with a new cosmetic non‐steroidal gel cream: Clinical, laboratory, and instrumental evaluation

Facial Seborrheic Dermatitis in HIV-Seropositive Patients: Evaluation of the Efficacy and Safety of a Non-Steroidal Cream Containing Piroctone Olamine, Biosaccharide Gum-2 and Stearyl Glycyrrhetinate – A Case Series

Evaluating the Impact of Antifungal Drugs on Human Health and Exploring Alternative Treatments

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