Treatment of cradle cap in infants with a new cosmetic non‐steroidal gel cream: Clinical, laboratory, and instrumental evaluation

Micali, Giuseppe; Pulvirenti, Nella; Dall’Oglio, Federica; Tedeschi, Aurora; Quattrocchi, Enrica; Lacarrubba, Francesco

doi:10.1111/jocd.14095

Cited by 5 publications

(5 citation statements)

References 16 publications

(34 reference statements)

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“…[13][14][15] Finally, in both adults and children, some clinical trials highlight the advantages of dermoscopy as a tool for a more accurate SD severity grading as well as for its therapeutic monitoring and follow-up. 16,17…”

Section: Dermatoscopymentioning

confidence: 99%

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An Overview of the Diagnosis and Management of Seborrheic Dermatitis

Dall’Oglio¹,

Nasca²,

Gerbino³

et al. 2022

CCID

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Seborrheic dermatitis (SD) is a common chronic inflammatory skin disorder that mostly affects young adults in areas rich in sebaceous glands (scalp, face, and trunk). In adolescents and adults, SD clinical presentation may range from mild patches to diffuse scalp scaling. In infants, it mainly occurs on the scalp as yellowish, scaly patches (“cradle cap”). In adults, several environmental triggers are likely to promote SD development, along with fungal colonization by Malassezia spp., sebaceous gland activity, as well as immunosuppression, endocrine, neurogenic and iatrogenic factors. In children, early occurrence in the first trimester suggests the role of excessive sebaceous gland activity from maternal hormones, along with cutaneous microbiome alterations. The diagnosis of SD is usually clinical, and specific laboratory and/or instrumental investigations are seldom required. Treatment is aimed at modulating sebum production, reducing skin colonization by Malassezia spp., and controlling inflammation. In adults, mild-to-moderate scalp SD forms can be managed with topical antifungals (ketoconazole, ciclopirox, miconazole) or antiinflammatory (mild-to-moderate potency corticosteroids) or keratolytic/humectant (propylene glycol) agents. Recommended topical therapeutic options for mild-to-moderate facial or body areas SD include topical ketoconazole, ciclopirox, clotrimazole, mild-to-moderate potency corticosteroids, lithium succinate/gluconate, and topical calcineurin inihibitors ( off-label use ). In severe and/or resistant cases, the use of systemic antifungal drugs (terbinafine, itraconazole), as well as UVB phototherapy, may be considered. In children, scant scientific evidence supports the effectiveness and safety of topical drugs, and “cradle cap” is usually successfully managed with baby shampoos enriched with emollient agents and vegetable oils. Alternatively, similarly to adult scalp SD, medical device shampoos with antiinflammatory and antifungal properties, containing piroctone olamine, bisabolol, alyglicera, telmesteine, may be used. Beyond pharmacological treatments, an appropriate cosmetic approach, if correctly prescribed, may improve therapeutic outcomes.

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Section: Dermatoscopymentioning

confidence: 99%

“…Similar to adult scalp SD, AIAF medical device shampoos, as confirmed by Cochrane Review and by some clinical trials, may be used. 16,[47][48][49] Non-Scalp Seborrheic Dermatitis…”

Section: Sd Of the Scalp In Children: Topical Treatmentmentioning

confidence: 99%

An Overview of the Diagnosis and Management of Seborrheic Dermatitis

Dall’Oglio¹,

Nasca²,

Gerbino³

et al. 2022

CCID

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“…In addition, the dysbiosis of skin microbiome is an extrinsic factor associated with SD, where the imbalance of microorganisms has been observed 9–12 . SD is normally treated with topical corticosteroids and anti‐fungal drugs 13–15 . Tacrolimus has been used to treat SD, but it is expensive and has some side effects 16 .…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11][12] SD is normally treated with topical corticosteroids and anti-fungal drugs. [13][14][15] Tacrolimus has been used to treat SD, but it is expensive and has some side effects. 16 Recombinant human thymosin beta-4 (rhTβ4) has been reported to be another treatment aiming to control skin microbial homeostasis.…”

mentioning

confidence: 99%

Analysis of cutaneous bacterial microbiota of Thai patients with seborrheic dermatitis

Dityen

Soonthornchai

Kueanjinda

et al. 2022

Experimental Dermatology

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Seborrheic dermatitis (SD) is a chronic inflammatory skin condition that occurs in body areas that contain profuse sebaceous glands. Skin microbiota are diverse across ethnic groups and its dysbiosis has been implicated in the pathogenesis of SD. Here, we reported the contribution of cutaneous bacterial microbiota to SD in the Thai population. Healthy individuals and patients with scalp SD were recruited into the study. Normal skin, scalp skin lesion (SL) and non‐lesion sites (SNL) samples were collected using a tape stripping method and next‐generation sequencing of 16S rRNA for microbiome analysis. Although bacterial diversity in all sample groups was not statistically different, a population of bacteria commonly found on skin of scalp showed signs of dysbiosis. Apart from the reduction of Corynebacterium spp., SD‐specific microbiota was dominated by Firmicutes at taxa level and Pseudomonas spp., Staphylococcus spp. and Micrococcus spp. at genus level. The dysbiosis of the skin microbiota in SD was specifically described as an alteration of bacteria populations commonly found on scalp skin, implying that managing and controlling the cutaneous bacterial microbiome can alleviate and prevent SD and pave the way for the development of new SD treatments.

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“…However, only 10 infants participated. 3 Additionally, a kerato-regulating formulation with patented active ingredients (-hydroxy acid esters, capryloyl-glycine complex, butylavocadate, aloe vera, bourrache oil) for ISD has been explored but has been studied only twice in previous literature. Since fungal density may be an important hallmark of seborrheic dermatitis, targeting evidence-based research and practicing dermatologists' efforts toward antifungal shampoos could be worthwhile.…”

mentioning

confidence: 99%