Exploring challenges ahead of nanotechnology for biomedicine

Rau, Julietta V.; Santis, Roberto De; Ciofani, Gianni

doi:10.1016/j.bioactmat.2017.09.004

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…14 Recent advancement in nanotechnology has received considerable attention in many scientific domains including biomedical science, materials science, medicine, engineering, etc. 15 This has also created new hope in the development of novel antibacterial and anti-infective agents. Typically, nanoparticles are materials with size less than 100 nm.…”

Section: ■ Introductionmentioning

confidence: 99%

Biofabrication of Gold Nanoparticles Using Capsicum annuum Extract and Its Antiquorum Sensing and Antibiofilm Activity against Bacterial Pathogens

et al. 2021

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The intensive use of antimicrobial agents has led to the emergence of multidrug resistance (MDR) among microbial pathogens. Such microbial (MDR) infections become more problematic in chronic diseases in which the efficacy of chemotherapeutic agents is highly reduced. To combat the problem of drug resistance, inhibition of bacterial quorum sensing (QS) and biofilms are considered as promising strategies in the development of anti-infective agents. In this study, gold nanoparticles (AuNPs-CA) were biofabricated using Capsicum annuum aqueous extract and characterized. The AuNPs-CA were tested against the QS-controlled virulence factors and biofilms of Pseudomonas aeruginosa PAO1 and Serratia marcescens MTCC 97. AuNPs-CA were found to be crystalline in nature with average particle size 19.97 nm. QS-mediated virulent traits of P. aeruginosa PAO1 such as pyocyanin, pyoverdin, exoprotease activity, elastase activity, rhamnolipids production, and swimming motility were reduced by 91.94, 72.16, 81.82, 65.72, 46.66, and 46.09%, respectively. Similarly, dose-dependent inhibition of virulence factors of S. marcescens MTCC 97 was recorded by the treatment of AuNPs-CA. The biofilm development and exopolysaccharide (EPS) production also decreased significantly. Microscopic analysis revealed that the adherence and colonization of the bacteria on solid support were reduced to a remarkable extent. The findings indicate the possibility of application of green synthesized gold nanoparticles in the management of bacterial infection after careful in vivo investigation.

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Section: ■ Introductionmentioning

confidence: 99%

Biofabrication of Gold Nanoparticles Using Capsicum annuum Extract and Its Antiquorum Sensing and Antibiofilm Activity against Bacterial Pathogens

et al. 2021

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“…In the last few decades, nanotechnology has received great attention in numerous disciplines of science such as materials science, biomedical engineering, medicine, etc. 14 Nanomaterials are typically less than 100 nm but sometimes its size may be more than 100 nm. Inorganic nanomaterials such as silver, gold, platinum, iron, titanium, zinc, etc., are of great choice for biomedical applications in diagnosis, photo-thermal therapy, optical and electrical sensing, etc.…”

Section: Introductionmentioning

confidence: 99%

Effective inhibition and eradication of pathogenic biofilms by titanium dioxide nanoparticles synthesized using Carum copticum extract

et al. 2021

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“…[5][6][7][8] The advancement of nanotechnology has significantly expanded the scope of material science, leading to the emergence of innovative technologies and offering new possibilities for laboratory testing, particularly in the areas of tests. [9][10][11][12][13] Among them, DNA, originally recognized as the carrier of genetic information based on principles of base complementarity, has assumed a vital role in the design of molecular machines and sensing components, facilitating molecular recognition and information extraction due to its distinctive features such as binding specificity and structural stability. [14][15][16][17][18] In 1994, Adleman proposed that DNA possesses the potential to serve as a means for computationally addressing a small example of a standard problem within the field of computer science, marking the initial establishment of DNA computing.…”

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confidence: 99%

DNA logic programming: From concept to construction

Zhang,

Hu,

et al. 2023

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DNA programming, which is based on the principle of base complementary pairing and Boolean operations, exhibits organizational structures and algorithms similar to those observed in machine language. Consequently, the practical implementation of DNA logic programming can be achieved through the utilization of programming techniques, enabling the discrimination and output generation. In recent years, DNA programming has witnessed a convergence with disciplines, such as life sciences, medicine, and other interdisciplinary areas, thereby giving rise to an advanced research system that yields valuable insights. This development has paved the way for multidisciplinary cutting‐edge research. Furthermore, the successful transition from conceptualization to the practical implementation of DNA programming has been accomplished. This review summarizes the recent advances in DNA logic programming within the biomedical fields, specifically emphasizing the conceptualization and execution of DNA logic programming constructs. The benefits and obstacles associated with the adoption of DNA programming in cutting‐edge research areas are also highlighted.

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Exploring challenges ahead of nanotechnology for biomedicine

Cited by 4 publications

References 8 publications

Biofabrication of Gold Nanoparticles Using Capsicum annuum Extract and Its Antiquorum Sensing and Antibiofilm Activity against Bacterial Pathogens

Biofabrication of Gold Nanoparticles Using Capsicum annuum Extract and Its Antiquorum Sensing and Antibiofilm Activity against Bacterial Pathogens

Effective inhibition and eradication of pathogenic biofilms by titanium dioxide nanoparticles synthesized using Carum copticum extract

DNA logic programming: From concept to construction

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