Exploring HIV infection and susceptibility to measles among older children and adults in Malawi: a facility-based study

Polonsky, Jonathan; Singh, Beverley; Masiku, Charlie; Langendorf, Céline; Kagoli, Matthew; Hurtado, Northan; Berthelot, Mathilde; Heinzelmann, Annette; Puren, Adrian; Grais, RFebecca F

doi:10.1016/j.ijid.2014.12.010

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…Other reports have shown that HIV infection is associated with greater severity of measles disease, higher mortality and prolonged measles virus shedding (Polonsky et al 2015).…”

Section: Measlesmentioning

confidence: 95%

The re-emergency and persistence of vaccine preventable diseases

Borba

Vidal

Moreira

2015

An. Acad. Bras. Ciênc.

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The introduction of vaccination worldwide dramatically reduced the incidence of pathogenic bacterial and viral diseases. Despite the highly successful vaccination strategies, the number of cases among vaccine preventable diseases has increased in the last decade and several of those diseases are still endemic in different countries. Here we discuss some epidemiological aspects and possible arguments that may explain why ancient diseases such as, measles, polio, pertussis, diphtheria and tuberculosis are still with us.

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“…Other reports have shown that HIV infection is associated with greater severity of measles disease, higher mortality and prolonged measles virus shedding (Polonsky et al 2015).…”

Section: Measlesmentioning

confidence: 95%

The re-emergency and persistence of vaccine preventable diseases

Borba

Vidal

Moreira

2015

An. Acad. Bras. Ciênc.

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“…A facility-based study was conducted to assess differences in levels of measles antibodies between HIV-infected and uninfected individuals in Chiradzulu district, Malawi [6]. A secondary objective of this study was to correlate self-reported measles protective status with measles serological result.…”

Section: Methodsmentioning

confidence: 99%

“…As part of a larger study on measles serological protection in HIV infected and uninfected individuals in Chiradzulu district [6], we collected data on measles vaccination and disease history. Our aim was to explore self-reported measles protective status, and comparing this with measles serological result, in order to inform local assessments of vaccine coverage and provide important guidance on how these assessments could be improved to ensure control strategies are successful.…”

Section: Introductionmentioning

confidence: 99%

Measles seroprevalence in Chiradzulu district, Malawi: Implications for evaluating vaccine coverage

Polonsky¹,

Juan-Giner²,

Hurtado

et al. 2015

Vaccine

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Safety and Immunogenicity of Measles Vaccination in HIV-Infected and HIV-Exposed Uninfected Children: A Systematic Review and Meta-Analysis

et al. 2018

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Background HIV-infected and HIV-exposed uninfected (HEU) children have an increased risk of measles that may be due to altered immune responses or suboptimal timing of measles vaccination. We aimed to evaluate the safety and immunogenicity of measles vaccination in HIV-infected and HEU children. Methods For this systematic review and meta-analysis, we searched PubMed, Embase, Cochrane Library, CINAHL, Global Health Library and IndMED on May 9, 2018. Studies were included if they reported on safety or seroresponse (either seroprotection/seropositivity/seroconversion) after measles vaccination in HIV-infected or HEU children. We calculated pooled estimates to compare immunogenicity outcomes between HIV-infected, HEU and HIV-unexposed children, using risk ratios [RRs] (with 95%CIs). PROSPERO registration number: CRD42017057411. Findings Seventy-one studies met the inclusion criteria (15,363 children). Twenty-eight studies reported on safety; vaccine-associated adverse events and deaths were uncommon. Sixty-two studies reported on immunogenicity, 27 were included in the meta-analysis. HIV-infected children had lower seroresponse rates after primary vaccination compared with HIV-unexposed (RR 0.74; 95%CI: 0.61–0.90, I 2 = 85.9%) and HEU children (0.78; 0.69–0.88, I 2 = 77.1%), which was mitigated by antiretroviral therapy and time interval between vaccination and serology. HEU and HIV-unexposed children had similar seroresponses. Vaccination at 6-months resulted in similar proportions of HIV-infected children having seroresponse compared with HIV-unexposed (0.96; 0.77–1.19) and HEU children (1.00; 0.73–1.37, I 2 = 63.7%). Interpretation Primary measles vaccination at 6-months of age may provide protection against measles during early infancy in settings with high prevalence of maternal HIV-infection, however, further studies are needed to evaluate this strategy in HEU children and HIV-infected children receiving antiretroviral therapy. Funding South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation in Vaccine Preventable Diseases; Medical Research Council: Respiratory and Meningeal Pathogens Research Unit.

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Exploring HIV infection and susceptibility to measles among older children and adults in Malawi: a facility-based study

Abstract: We found no evidence that HIV infection contributes to the risk of measles infection among adults, but HIV-infected children (including at ages older than previously reported), were less likely to be seroprotected in this sample.

Cited by 7 publications

References 38 publications

The re-emergency and persistence of vaccine preventable diseases

The re-emergency and persistence of vaccine preventable diseases

Measles seroprevalence in Chiradzulu district, Malawi: Implications for evaluating vaccine coverage

Safety and Immunogenicity of Measles Vaccination in HIV-Infected and HIV-Exposed Uninfected Children: A Systematic Review and Meta-Analysis

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