Introduction: Open science is a valuable path to boost the global potential of scientific research by removing barriers for producing, disseminating, and putting science into practice, with the spirit of collaboration, inclusivity and focusing on communities’ rising demands. Open science principles instigate the management of scientific knowledge and the enhancement of abilities such as research, project management, team-building skills, and numerous others, which are essential for medical practice according to international recommendations, although still underexplored by medical schools.Methods: Open science, peer education, student leadership and developing of scientific skills were cornerstones to promote the Training New Research Trainers, the first edition of a national Brazilian student-led online workshop aiming to capacitate medical students in such targeted competencies and abilities through active teaching and learning methodologies.Results: Despite the challenges of online format, as impairment in some dynamics and assessment methods, it improved the access to the event from all Brazilian regions, totaling 409 submissions. Thus, it was necessary to have a previous selection of participants and adjustments in the workshop to assist twice the expected attendants.Discussion and Conclusions: Training New Research Trainers surpassed the national distribution inequalities of research opportunities and resources; mirrored open science bases in terms of access, education and methodology; and showed to be a promising opportunity for students to be protagonists of their learning process and to contribute to future changes in their reality, especially regarding the public health landscape. Improvements and consolidation of the workshop protocol and its expansion through national and international partnerships are the following goals.