Exploring Mg-Zn-Ca-Based Bulk Metallic Glasses for Biomedical Applications Based on Thermodynamic Approach

Ramya, M.; Sarwat, Syed Ghazi; Udhayabanu, V.; Raj, Baldev; Ravi, K.R.

doi:10.1007/s11661-015-3124-9

Cited by 19 publications

(5 citation statements)

References 52 publications

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“…Kinking of the LPSO phases strengthen the Mg-Zn-Ca-Y alloy due to refinement [24]. Also, it pays for substantial quantity of plastic deformation to the Mg-Zn-Ca-Y alloy, contributing to ductility of the material [25].…”

Section: Resultsmentioning

confidence: 99%

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Biodegradable Mg-Zn-Ca-Y glass forming alloy with an amendment in mechanical properties and corrosion resistance

Ramya

2022

Preprint

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For orthopedic application, the biodegradable implant material should possess a combination of good mechanical strength, reasonable ductility and optimal corrosion resistance. The key challenge in developing magnesium (Mg) based metallic glasses as viable orthopedic implant is to improve its mechanical properties as well as its corrosion resistance. In this work, an attempt has been made to improve the mechanical behavior and corrosion resistance of Mg-Zn-Ca glass forming alloy using yttrium (Y) addition. Mg66Zn30Ca4 metallic glass and a novel Mg-Zn-Ca-Y glass forming alloy with nominal composition of Mg52.5Zn40.5Ca5Y2 were synthesized. The effect of Y addition on the glass forming ability, mechanical behavior and corrosion properties of Mg-Zn-Ca metallic glass was investigated using X-ray diffraction, differential scanning calorimetry, hardness tests, compressive tests and electrochemical studies. Mg66Zn30Ca4 was completely amorphous while the glass forming ability reduced with Y addition. Enhancement in mechanical properties and corrosion resistance were observed upon addition of Y. Enrichment of mechanical behavior and corrosion resistance in Mg52.5Zn40.5Ca5Y2 alloy was attributed to the presence of Mg12YZn LPSO and Mg3YZn6 icosahedral phases formed due to the addition of Y.

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Section: Resultsmentioning

confidence: 99%

“…To make the analysis more reliable, in this study the Mg-Zn-Ca-Y glass forming alloy has been chosen based on the HHS P parameter. As discussed in author's earlier publication [24],…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Mg-Zn-Ca-Y glass forming alloy with an amendment in mechanical properties and corrosion resistance

Ramya

2022

Preprint

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“…Since contaminants like oxygen and hydrogen are capable of escalating atomic packing density, glass forming ability (GFA) or amorphisation of a system has been conceived to improve from their introduction. There are ample reports suggesting how intakes of oxygen improve , and contrarily widen , factors that enhance amorphisation propensity [31,32]. Fe–Cr, Al–Ti, Ni–Nb [2] etc.…”

Section: Influence On the Propertiesmentioning

confidence: 99%

Contamination in wet-ball milling

Sarwat

2017

Powder Metallurgy

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The top-down approach of mechanical ball milling/alloying is the most commonly adopted route towards materials development. It is however surprising that despite the large impact that it has, process induced contamination (particularly from process control agents (PCAs)), remains less studied and often ignored. In this article, a theory that explains the cause of PCA-induced contamination is postulated. An attempt is then made through reviewing the literature to reason why there is ignorance. Influence of contamination on material's properties is then reviewed; revealing the dubious behaviour of contaminants. No first-hand experimental data are presented. The article is written with the interest and objective to create awareness on contamination, which remains highly under appreciated.

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“…The motivation for this study is to prepare metal matrix composites based on Mg-Zn-Ca glass forming alloy as the matrix and HA p as reinforcement. According to the authors' previous work on thermodynamic predictions of glass forming alloy based on G CE and P HHS parameters [9,10], Mg 66 Zn 30 Ca 4 composition has shown good glass forming ability. Hence, this alloy has been chosen as the matrix material.…”

Section: Introductionmentioning

confidence: 98%

Hydroxyapatite particle (HAp) reinforced biodegradable Mg-Zn-Ca metallic glass composite for bio-implant applications

Ramya¹,

Pillai²,

Selvakumar³

et al. 2018

Biomed. Phys. Eng. Express

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Biodegradable materials suitable for medical application with improved corrosion resistance and good biocompatibility along with enhanced mechanical properties are the need of the hour. Such properties in Mg-Zn-Ca glass forming alloy used as a metal matrix can be obtained through proper reinforcement. Hydroxyapatite (HA) which is a mineral constituent of natural bone has a wide range of medical applications because of its excellent biocompatibility and bioactivity. They promote bone cell adhesion and osteoblastic proliferation. In the present study, the influence of HA particle (HA p ) addition on the glass forming ability, corrosion resistance, mechanical behavior and cytocompatibility of Mg 66 Zn 30 Ca 4 alloy has been investigated. The addition of HA p decreases the glass forming ability of Mg 66 Zn 30 Ca 4 alloy. Significant improvement in corrosion resistance along with marginal improvement in mechanical properties is observed upon addition of HA p . Moreover, HA p incorporation into Mg 66 Zn 30 Ca 4 metallic glass has enhanced the cell viability and cell adhesion of human osteoblast-like cell (MG63) cells, complementing the excellent biocompatibility, bioactivity, osteoconductivity and osteoinductivity of hydroxyapatite mineral due to its biomimetic nature. HA reinforcement is not only a promising approach to improve the corrosion resistance, but also offers a biomimitic interface to enhance osseointegration and overall competence of orthopedic implants.

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Exploring Mg-Zn-Ca-Based Bulk Metallic Glasses for Biomedical Applications Based on Thermodynamic Approach

Cited by 19 publications

References 52 publications

Biodegradable Mg-Zn-Ca-Y glass forming alloy with an amendment in mechanical properties and corrosion resistance

Biodegradable Mg-Zn-Ca-Y glass forming alloy with an amendment in mechanical properties and corrosion resistance

Contamination in wet-ball milling

Hydroxyapatite particle (HAp) reinforced biodegradable Mg-Zn-Ca metallic glass composite for bio-implant applications

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