Exploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds

Signorelli, Federica; Orrù, Luigi; Napolitano, F.; Matteis, Giovanna De; Scatà, Maria Carmela; Catillo, G.; Marchitelli, Cinzia; Moioli, B.

doi:10.1016/j.livsci.2009.02.014

Cited by 27 publications

(17 citation statements)

References 29 publications

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“…The variable effect of genes on milk production and composition traits has been observed previously (Hastings et al, 2006;Comin et al, 2008;Signorelli et al, 2009;Krasnopiorova et al, 2012). In theory, genes do not function alone, but have a close relationship with a number of genes in a genome; some of these genes are involved in regulating expression, particularly for quantitative traits.…”

Section: Introductionsupporting

confidence: 56%

“…Some candidate genes were found to have significant effects on the traits, including the casein gene family and the betalactoglobulin (LGB) (Boettcher et al, 2004;Comin et al, 2008), acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) (Kuehn et al, 2007;Nowacka-Woszuk et al, 2008;Signorelli et al, 2009), growth hormone (GH) (Pawar et al, 2007;Mullen et al, 2011;Heidari et al, 2012;Krasnopiorova et al, 2012), and luteinizing hormone receptor (LHR) genes (Hastings et al, 2006). There is strong evidence that a group of genes may be used as markers for selection programs.…”

Section: Introductionmentioning

confidence: 99%

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Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

2015

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ABSTRACT. The objectives of this study were to determine the effects of a single gene and composite genotype of the casein gene family, including the beta-lactoglobulin gene (beta-LGB), acyl-CoA: diacylglycerol acyltransferase 1 gene (DGAT1), growth hormone gene (GH), and luteinizing hormone receptor gene (LHR) on milk yield, milk composition, the percentage of fat, protein, solids-not-fat, and total solid in crossbred Holsteins. A total of 231 crossbred Holstein cows were examined for the study. The genotype of the beta-casein gene was analyzed by allele-specific polymerase chain reaction, while the alpha-S1, alpha-S2, kappa-casein, DGAT1, beta-LGB, and GH genes were analyzed using a polymerase chain reaction-restriction fragment length polymorphism assay. The association between genes and milk yield and milk composition was analyzed. Three pairs of genes, for which significant associations were detected, were beta + kappacasein, DGAT1 + beta-casein, and GH + beta-LGB. In the single-gene model, most loci are significantly associated with traits. A significant 2561-2571 (2015) association between the composite genotype and the traits was detected in all composite genotypes. GH + beta-LGB appears to be the most suitable variants for improving milk production and percentage of milk protein. Overall, the effects of the composite genotype and single gene were different. A physical or functional relationship between genes is necessary for investigating gene markers.

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Section: Introductionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

2015

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“…In contrast, a positive effect of the A allele on increased 305-d milk yield was revealed in a Canadian Jersey population (Kgwatalala et al, 2009). Contrary to the current study, no significant effect of this SNP on milk yield was found in Dutch Holstein-Friesian (Schennink et al, 2008), Polish Holstein-Friesian (Komisarek & Dorynek, 2009) and four breeds of Friesian, Jersey, Piedmontese and Valdostana (Signorelli et al, 2009), respectively. The current result also revealed an effect of the SCD1-A293V polymorphism on protein percentage.…”

Section: Resultscontrasting

confidence: 99%

“…No significant relationship was found between the SCD1-A293V genotypes and breeding value for milk and fat yield, fat percentage and SCS (P >0.05). Similar to the current findings, no association has been reported between the SCD1-A293V and fat yield and percentage (Macciotta et al, 2008;Schennink et al, 2008;Kgwatalala et al, 2009;Komisarek & Dorynek, 2009;Signorelli et al, 2009) and SCS (Komisarek & Dorynek, 2009). …”

Section: Resultssupporting

confidence: 86%

“…Cows homozygous for the V allele showed higher protein percentage in their milk compared with the AA and AV genotypes (P <0.01) and substituting the A allele with the V allele increased protein percentage by 0.02% (Table 4). Findings of other studies showed no association of the SNP with this trait (Schennink et al, 2008;Kgwatalala et al, 2009;Komisarek & Dorynek, 2009;Signorelli et al, 2009). However, an effect of this polymorphism on protein yield was reported in a Canadian Jersey population (Kgwatalala et al, 2009) and in Italian Holsteins (Macciotta et al, 2008).…”

Section: Resultsmentioning

confidence: 81%

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Effect of polymorphisms in the ABCG2, LEPR and SCD1 genes on milk production traits in Holstein cows

et al. 2016

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This study was performed to investigate the association between polymorphisms in the ABCG2 (ATPbinding cassette sub-family G member 2), LEPR (leptin receptor) and SCD1 (stearoyl-coenzyme A desaturase 1) genes and milk production traits in Holstein dairy cows in Iran. The analysis was conducted on 816 lactations from 408 Iranian Holstein cows. Genotyping was carried out using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) technique. The results of the association study revealed that cows with genotype AC of the ABCG2-Y581S single nucleotide polymorphism (SNP) had lower breeding value for milk yield compared with the AA genotype, but showed significantly higher fat and protein percentages. Cows that were homozygous for allele T at the LEPR-T945M locus had higher breeding value for fat yield than those that were homozygous for the C allele. Regarding the SCD1-A293V SNP, cows with genotype AV produced a higher 305-day milk yield in comparison with cows with the VV genotype. Furthermore, cows that were homozygous for allele V showed a significantly higher protein percentage compared with AA and AV genotypes. The results of this study suggest that these SNPs have the potential to be used in programmes based on genomic selection in Iranian dairy herds. ______________________________________________________________________________________

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Origin of Fatty Acids and Influence of Nutritional Factors on Milk Fat

Palmquist

Harvatine

2020

Advanced Dairy Chemistry, Volume 2

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Exploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds

Cited by 27 publications

References 29 publications

Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

Effect of polymorphisms in the ABCG2, LEPR and SCD1 genes on milk production traits in Holstein cows

Origin of Fatty Acids and Influence of Nutritional Factors on Milk Fat

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