Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure

Kažukauskienė, Nijolė; Burkauskas, Julius; Macijauskienė, Jūratė; Mickuvienė, Narseta; Brožaitienė, Julija

doi:10.1177/1474515118772828

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…What is interesting, while multiple studies show that lower IL-6 concentration is correlated with lower cardiovascular risks, it has been reported that decreased levels of inflammatory biomarkers, including hs-CRP and IL-6, were associated with worse health-related quality of life (HRQoL) in patients with CAD and heart failure [ 49 ].…”

Section: Biomarkersmentioning

confidence: 99%

“…Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure [49] IL-6, CRP Decreased levels of inflammatory biomarkers, including IL-6 and hs-CRP, were associated with worse health-related quality of life in patients with CAD and heart failure.…”

Section: C-reactive Protein Increase In Acute Myocardial Infarction [34] Crpmentioning

confidence: 99%

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Recognized and Potentially New Biomarkers—Their Role in Diagnosis and Prognosis of Cardiovascular Disease

et al. 2021

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Atherosclerosis and its consequences are the leading cause of mortality in the world. For this reason, we have reviewed atherosclerosis biomarkers and selected the most promising ones for review. We focused mainly on biomarkers related to inflammation and oxidative stress, such as the highly sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), and lipoprotein-associated phospholipase A2 (Lp-PLA2). The microRNA (miRNA) and the usefulness of the bone mineralization, glucose, and lipid metabolism marker osteocalcin (OC) were also reviewed. The last biomarker we considered was angiogenin (ANG). Our review shows that due to the multifactorial nature of atherosclerosis, no single marker is known so far, the determination of which would unambiguously assess the severity of atherosclerosis and help without any doubt in the prognosis of cardiovascular risk.

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Section: Biomarkersmentioning

confidence: 99%

Section: C-reactive Protein Increase In Acute Myocardial Infarction [34] Crpmentioning

confidence: 99%

Recognized and Potentially New Biomarkers—Their Role in Diagnosis and Prognosis of Cardiovascular Disease

et al. 2021

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“…Similarly, patients with controlled blood pressure have better overall satisfaction with their medications and HRQoL. Patients who had no adverse events and experienced less anxiety and depression had significantly higher overall treatment satisfaction and better HRQoL ( 18 – 21 ).…”

Section: Introductionmentioning

confidence: 97%

Health-related quality of life and treatment satisfaction of patients with cardiovascular disease in Ethiopia

Tito

Gebremariam

Beyene

et al. 2022

Front. Public Health

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PurposeCardiovascular disease is the most prevalent health problem associated with poorer health-related quality of life (HRQoL). We aimed to assess HRQoL and treatment satisfaction of cardiovascular disease patients in Ethiopia.MethodsA cross-sectional survey was conducted among adults attending the outpatient cardiac clinic at Tikur Anbessa Specialized Hospital from July to September 2021. Patients were recruited consecutively during follow-up visits. Treatment Satisfaction Questionnaire for Medication and European Quality of life questionnaires were used to evaluate treatment satisfaction and HRQoL, respectively. Kruskal-Wallis and Mann-Whitney U-tests were used to compare utility weights between patient subgroups. Utility values were computed using disutility weights of the Ethiopian general population derived using a hybrid regression model. Tobit regression modeling was used to explore factors associated with poor HRQoL. Statistical significance was determined at p < 0.05.ResultsA total of 357 patients participated in the study with a mean age of 49.3 ± 17.8 years. The most frequently reported health problems were pain/discomfort (75.4%), followed by mobility (73.4%). The median (interquartile range) European Quality questionnaires five dimensions with five levels utility (EQ-5D-5L) and European Quality of life Visual Analog Scale scores were 0.84 (0.55–0.92) and 70.0 (50.0–85.0), respectively. The highest and lowest mean (standard deviation) treatment satisfaction scores were for the convenience and safety satisfaction dimensions: 87.7 (17.9) and 53.1 (33.5), respectively. Unemployment, older age, previous hospital admission, non-adherence to lifestyle modification, and presence of three or more cardiovascular disease factors were significantly negatively associated with HRQoL.ConclusionsOverall, the study found that cardiovascular disease had a profound negative effect on HRQoL and patient treatment satisfaction. We suggest that interventions to enhance HRQoL and treatment satisfactions should focus on modifiable associated factors including lifestyle changes and controlling disease progression.

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“…Regarding the expected instability of TDP over time, we also wonder whether it may be an expression of maladaptive coping strategies rather than their cause. At any rate, TDP is linked to lowered quality of life in a variety of diseases, e.g., multiple sclerosis [28], coronary artery disease [29], diabetes mellitus [30], and rheumatoid arthritis [31]. NA is held responsible for effectuating the loss in QoL [31].…”

Section: Introductionmentioning

confidence: 99%

Negative Affect, Type D Personality, Quality of Life, and Dysfunctional Outcomes of Total Knee Arthroplasty

Vogel

Riediger

Krippl

et al. 2019

Pain Research and Management

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Background Type D personality (TDP) is a sign of tapered stress and compromises treatment outcomes including those of hip arthroplasty. The common dissatisfaction with total knee arthroplasty (TKA) is predicted by fear avoidance, pain catastrophizing and emotional lability, with poor quality of life (QoL) reflecting these strains. This study is the first to investigate the influence of TDP on TKA assuming (1) negative affect (NA) to be linked to fear avoidance and to increased dissatisfaction with TKA and (2) the expression of NA and social inhibition (SI) to not be stable over time. Method We studied 79 participants using the brief symptom inventory-18, the pain-catastrophizing scale, the Tampa scale of kinesiophobia, the SF-36, and the WOMAC preoperatively and 12 months postoperatively. T-test and regression were used to compare the variables of interest between groups built based upon outcome severity. Result NA at follow-up predicted knee pain (p=0.02) and knee function (p < 0.01) at follow-up. Contrarily, increased expressions of NA/SI at follow-up were predicted by NA (p=0.04) and rumination (p=0.05) at the baseline. Conclusion The present results suggest the postoperative increase of NA to be linked to dysfunctional outcomes of TKA due to an interaction with pain catastrophizing. Baseline self-rated physical health did not connect to the dissatisfaction with TKA 1-year postoperatively.

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Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure

Abstract: Even after controlling for socio-demographic and clinical risk factors including mental distress symptoms, lower levels of inflammatory biomarkers were associated with worse HRQoL.

Cited by 11 publications

References 31 publications

Recognized and Potentially New Biomarkers—Their Role in Diagnosis and Prognosis of Cardiovascular Disease

Recognized and Potentially New Biomarkers—Their Role in Diagnosis and Prognosis of Cardiovascular Disease

Health-related quality of life and treatment satisfaction of patients with cardiovascular disease in Ethiopia

Negative Affect, Type D Personality, Quality of Life, and Dysfunctional Outcomes of Total Knee Arthroplasty

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