Recognized and Potentially New Biomarkers—Their Role in Diagnosis and Prognosis of Cardiovascular Disease

Bargieł, Weronika; Cierpiszewska, Katarzyna; Maruszczak, Klara; Pakula, Anna; Szwankowska, Dominika; Wrzesińska, Aleksandra; Gutowski, Łukasz; Formanowicz, Dorota

doi:10.3390/medicina57070701

Cited by 21 publications

(23 citation statements)

References 152 publications

(250 reference statements)

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“…For example, in HF, altered circulating levels of miRNAs were reported for miR-122, miR-210, miR-423-5p, miR-499, miR-622, miR-16, miR-27a, miR-101, and miR-150. Such miRNAs are suggested to play a role as diagnostic and prognostic CVD biomarkers [ 456 , 457 , 458 , 459 ].…”

Section: Future: Prospective Biomarkers For Cvdsmentioning

confidence: 99%

Cardiovascular Biomarkers: Lessons of the Past and Prospects for the Future

Omran

Kyrou

Osman

et al. 2022

IJMS

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Cardiovascular diseases (CVDs) are a major healthcare burden on the population worldwide. Early detection of this disease is important in prevention and treatment to minimise morbidity and mortality. Biomarkers are a critical tool to either diagnose, screen, or provide prognostic information for pathological conditions. This review discusses the historical cardiac biomarkers used to detect these conditions, discussing their application and their limitations. Identification of new biomarkers have since replaced these and are now in use in routine clinical practice, but still do not detect all disease. Future cardiac biomarkers are showing promise in early studies, but further studies are required to show their value in improving detection of CVD above the current biomarkers. Additionally, the analytical platforms that would allow them to be adopted in healthcare are yet to be established. There is also the need to identify whether these biomarkers can be used for diagnostic, prognostic, or screening purposes, which will impact their implementation in routine clinical practice.

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Section: Future: Prospective Biomarkers For Cvdsmentioning

confidence: 99%

Cardiovascular Biomarkers: Lessons of the Past and Prospects for the Future

Omran

Kyrou

Osman

et al. 2022

IJMS

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“…ANG is a multifunctional protein known to induce blood vessel formation and is a potential biomarker for cardiac deterioration [20] and several types of cancers [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

“…ANG is a multifunctional protein known to induce blood vessel formation and is a potential biomarker for cardiac deterioration [ 20 ] and several types of cancers [ 24 , 25 , 26 ]. Within this context, we studied the effects of improving vitamin D status in circulating ANG and whether it is associated with other known cardiometabolic indices in vitamin D-deficient adults.…”

Section: Discussionmentioning

confidence: 99%

“…The protective effect of vitamin D status correction in endothelial cell function has been linked to decreased incidences of thromboembolism [ 17 ]. ANG is known to induce blood vessel formation and is a potential biomarker for cardiovascular diseases [ 18 , 19 , 20 ]. However, limited data is available as to whether vitamin D supplementation affects its circulating levels.…”

Section: Introductionmentioning

confidence: 99%

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Angiogenin Levels and Their Association with Cardiometabolic Indices Following Vitamin D Status Correction in Saudi Adults

Aldawsari

Sabico

Alamro

et al. 2022

Biology

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Angiogenin (ANG), a multifunctional protein known to induce blood vessel formation, is a potential biomarker for cardiovascular diseases; however, whether it is affected by vitamin D supplementation is not known. This interventional study in vitamin D-deficient Saudi adults was designed to investigate it. A total of 100 vitamin D-deficient Saudi adults aged 30–50 years were randomly selected to undergo 6-month vitamin D supplementation. Circulating levels of fasting glucose, lipids, vitamin D, apolipoproteins (AI, AII, B, CI, CII, CIII, E, and H), and ANG were measured using commercially available assays at baseline and after six months. Overall, vitamin D levels increased significantly post intervention. With this, levels of apo-CIII and apo-E significantly increased (p-values of 0.001 and 0.009, respectively) with a significant parallel decrease in apo-B (p = 0.003). ANG levels were significantly positively associated with most apolipoproteins and inversely correlated with HDL-cholesterol. Post intervention, the changes in ANG levels were positively correlated with apo-E (r = 0.32; p < 0.01 in all subjects and r = 0.40; p < 0.05 in males). Vitamin D supplementation may modestly affect ANG levels. The association observed between ANG and apo-E is worthy of further investigation since both biomarkers have been linked to neurodegenerative disorders.

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“…The clinical use of biomarkers can lead to modest improvements in the evaluation of the CV status beyond the above traditional CV risk factors [26].…”

Section: Plasmatic Biomarkers Of the CV Pathophysiological Statusmentioning

confidence: 99%

Beneficial Impact of Pork Dry-Cured Ham Consumption on Blood Pressure and Cardiometabolic Markers in Individuals with Cardiovascular Risk

et al. 2022

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Background: Evidence suggests that bioactive peptides reduce hypertension and affect certain metabolic pathways. Methods: Fifty-four volunteers with stage 1 prehypertension and/or hypercholesterolemia and/or basal glucose >100 mg/dL were recruited and randomized to pork dry-cured ham (n = 35) or cooked ham (placebo group; n = 19) for 28 days. After a wash-out period, meat products were changed for 28 additional days. Bioactive peptides composition and enzyme inhibitory activities of both products were characterized. Treatment comparisons for the main effects were made using a two (treatment) × two (times) repeated measures minus the effect of cooked ham (placebo). Results: 24 h mean systolic and diastolic pressures decreased up to 2.4 mmHg in the dry-cured ham period (treatment effect, p = 0.0382 y p = 0.0233, respectively) as well as the number of systolic pressure measures > 135 mmHg (treatment effect, p = 0.0070). Total cholesterol levels also decreased significantly after dry-cured ham intake (p = 0.049). No significant differences were observed between the two treatments for basal glucose, HOMA-IR index and insulin levels (p > 0.05). However, a significant rise of ghrelin levels was observed (treatment effect, p = 0.0350), while leptin plasma values slightly decreased (treatment effect, p = 0.0628). Conclusions: This study suggested the beneficial effects of regular dry-cured ham consumption on the improvement of systolic/diastolic blood pressures and facilitated the maintenance of metabolic pathways, which may be beneficial in the primary prevention of cardiovascular disease.

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Recognized and Potentially New Biomarkers—Their Role in Diagnosis and Prognosis of Cardiovascular Disease

Cited by 21 publications

References 152 publications

Cardiovascular Biomarkers: Lessons of the Past and Prospects for the Future

Cardiovascular Biomarkers: Lessons of the Past and Prospects for the Future

Angiogenin Levels and Their Association with Cardiometabolic Indices Following Vitamin D Status Correction in Saudi Adults

Beneficial Impact of Pork Dry-Cured Ham Consumption on Blood Pressure and Cardiometabolic Markers in Individuals with Cardiovascular Risk

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