Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model

Kim, Sook-Jin; Choi, Eun-Jeong; Choi, Go-Wun; Lee, Yong-Bok; Cho, Hea-Young

doi:10.1007/s00204-018-2365-y

Cited by 34 publications

(13 citation statements)

References 46 publications

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“…The toxicokinetics of PFDA were recently examined in male and female rats by Kim et al. (). After i.v.…”

Section: Appendix C– Toxicokinetics In Experimental Animalsmentioning

confidence: 99%

“…Kim et al. () investigated the tissue distribution and excretion of PFNA in rats i.v. administered PFNA at a dose of 3 mg/kg bw.…”

Section: Appendix C– Toxicokinetics In Experimental Animalsmentioning

confidence: 99%

“…where k human and k rat are the rate constants in human and rats, respectively, and BW human /BW rat refers to the body weight of humans and rats, respectively. Kim et al (2019) explored gender differences in humans for PFNA and PFDA using a PBPK model based on an in vivo study in male and female rats. The PBPK model was validated by comparing visually the data obtained from the analysis of the biological samples collected during the in vivo experiment with the predicted concentrations by model simulation.…”

Section: Pbpk Modellingmentioning

confidence: 99%

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Risk to human health related to the presence of perfluoroalkyl substances in food

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

333

265

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The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluoroalkyl substances ( PFAS s) in food. Based on several similar effects in animals, toxicokinetics and observed concentrations in human blood, the CONTAM Panel decided to perform the assessment for the sum of four PFAS s: PFOA , PFNA , PFH xS and PFOS . These made up half of the lower bound ( LB ) exposure to those PFAS s with available occurrence data, the remaining contribution being primarily from PFAS s with short half‐lives. Equal potencies were assumed for the four PFAS s included in the assessment. The mean LB exposure in adolescents and adult age groups ranged from 3 to 22, the 95th percentile from 9 to 70 ng/kg body weight (bw) per week. Toddlers and ‘other children’ showed a twofold higher exposure. Upper bound exposure was 4‐ to 49‐fold higher than LB levels, but the latter were considered more reliable. ‘Fish meat’, ‘Fruit and fruit products’ and ‘Eggs and egg products’ contributed most to the exposure. Based on available studies in animals and humans, effects on the immune system were considered the most critical for the risk assessment. From a human study, a lowest BMDL 10 of 17.5 ng/ mL for the sum of the four PFAS s in serum was identified for 1‐year‐old children. Using PBPK modelling, this serum level of 17.5 ng/ mL in children was estimated to correspond to long‐term maternal exposure of 0.63 ng/kg bw per day. Since accumulation over time is important, a tolerable weekly intake ( TWI ) of 4.4 ng/kg bw per week was established. This TWI also protects against other potential adverse effects observed in humans. Based on the estimated LB exposure, but also reported serum levels, the CONTAM Panel concluded that parts of the European population exceed this TWI , which is of concern.

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“…The toxicokinetics of PFDA were recently examined in male and female rats by Kim et al. (). After i.v.…”

Section: Appendix C– Toxicokinetics In Experimental Animalsmentioning

confidence: 99%

“…Kim et al. () investigated the tissue distribution and excretion of PFNA in rats i.v. administered PFNA at a dose of 3 mg/kg bw.…”

Section: Appendix C– Toxicokinetics In Experimental Animalsmentioning

confidence: 99%

Section: Pbpk Modellingmentioning

confidence: 99%

See 1 more Smart Citation

Risk to human health related to the presence of perfluoroalkyl substances in food

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

333

265

View full text Add to dashboard Cite

show abstract

“…Chapter Comment EFSA response human PBPK model that could described transfer of PFOA/PFOS compounds from breast milk to neonates, as the neonatal level of the compounds of interest was critical to the assessment. Although a number of studies are discussed in this section, Chou and Lin (2019), Kim et al (2018), Kim et al (2019) -does not appear in reference list, and Loccisano et al, 2011, it seems that none of the published models described human breast milk transfer of the PFOA/PFOS compounds. It appears that the Loccisano model was used as a starting point and modified to provide the needed predictive capability.…”

Section: Comment Numbermentioning

confidence: 99%

“…Studies published by Chou and Lin (2019), Kim et al (2018), Kim et al (2019) are included in Section 3.3.1.3, but the latter was missing in the reference list provided at the end of the opinion. This has now been added.…”

Section: Recommendati Onsmentioning

confidence: 99%

Outcome of a public consultation on the draft risk assessment of perfluoroalkyl substances in food

2020

EFSA Supporting Publications

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Gender differences in pharmacokinetics and tissue distribution of 4-n-nonylphenol in rats

et al. 2019

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Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model

Cited by 34 publications

References 46 publications

Risk to human health related to the presence of perfluoroalkyl substances in food

Risk to human health related to the presence of perfluoroalkyl substances in food

Outcome of a public consultation on the draft risk assessment of perfluoroalkyl substances in food

Gender differences in pharmacokinetics and tissue distribution of 4-n-nonylphenol in rats

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