Abstract. The COVID-19 pandemic has had significant effects on public health. Previous studies showed that the fear of COVID-19 was positively correlated with depression, anxiety, and stress. This study aims to compile and meta-analyze the relationship between fear of COVID-19 and depression, anxiety, and stress among the general population. The studies published between March 2020 and June 2021 were scanned from various databases (Google Scholar, PubMed, Web of Science [ISI], and SCOPUS). As a result of the literature search, 746 studies were reached, 88 studies were found suitable, and 21 met the inclusion criteria. Comprehensive Meta-Analysis (CMA Version 3.0) and metafor package in R were used for analyses. A strong relationship was observed between the fear of COVID-19 and anxiety ( r = .55, p < .001); there were moderate relationships between the fear of COVID-19 and depression ( r = .34, p < .001) and stress ( r = .44, p < .001). All these relationships were significant. The results showed that the relationships between the fear of COVID-19 and depression, anxiety, and stress had a high level of heterogeneity. Meta-regression analyses revealed that the average of the sample age was a significant predictor of the relationship between fear of COVID-19 and anxiety. However, other covariates (female proportion and culture) were not statistically significant for the relationship between fear of COVID-19 and anxiety. None of these covariates was significant predictors of the relationship between fear of COVID-19 with depression and stress. Although the current meta-analysis has some limitations, the results revealed that the fear of COVID-19 is associated with mental health problems such as depression, anxiety, and stress.