Exploring the association of organochlorine pesticides exposure and hearing impairment in United States adults

Long, Lili; Tang, Xinghua

doi:10.1038/s41598-022-15892-2

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…While the reviewed data indicate its clinical rarity, LFNSHL might go undiagnosed due to the late age of onset and additional, albeit rare, factors like environmental exposure to xenobiotics [Long and Tang, 2022]. Since LFNSHL does not impact speech recognition at first, this makes it less bothersome for the patient than high-frequency HLbut less likely to be diagnosed.…”

Section: Discussionmentioning

confidence: 99%

Monogenic Causes of Low-Frequency Non-Syndromic Hearing Loss

et al. 2023

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Background: Low-frequency non-syndromic hearing loss (LFNSHL) is a rare form of hearing loss (HL). It is defined as HL at low frequencies (≤2,000 Hz) resulting in a characteristic ascending audiogram. LFNSHL is usually diagnosed postlingually and is progressive, leading to HL affecting other frequencies as well. Sometimes it occurs with tinnitus. Around half of the diagnosed prelingual HL cases have a genetic cause and it is usually inherited in an autosomal recessive mode. Postlingual HL caused by genetic changes generally has an autosomal dominant pattern of inheritance and its incidence remains unknown. Summary: To date, only a handful of genes have been found as causing LFNSHL: well-established WFS1 and, reported in some cases, DIAPH1, MYO7A, TNC, and CCDC50 (respectively, responsible for DFNA6/14/38, DFNA1, DFNA11, DFNA56, and DFNA44). In this review, we set out audiological phenotypes, causative genetic changes, and molecular mechanisms leading to the development of LFNSHL. Key Messages: LFNSHL is most commonly caused by pathogenic variants in the WFS1 gene, but it is also important to consider changes in other HL genes, which may result in similar audiological phenotype.

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Section: Discussionmentioning

confidence: 99%

Monogenic Causes of Low-Frequency Non-Syndromic Hearing Loss

et al. 2023

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“…Moreover, research has indicated that exposure to certain heavy metals, such as cadmium and lead, is significantly associated with HL 7 – 9 . Long and Tang also found that organochlorine pesticides are linked to hearing impairment 10 . Additionally, the relationship between HL and certain types of air pollutants has been explored.…”

Section: Introductionmentioning

confidence: 99%

Higher exposure to 1,3-butadiene is associated with more severe hearing loss

Han,

Lee,

Suh

et al. 2024

Sci Rep

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While volatile organic compounds (VOCs) impair various organs, their influence on hearing loss (HL) has not been extensively researched. We aimed to identify the association between VOCs and HL or high-frequency hearing loss (HFHL). We extracted data on age, sex, pure tone audiometry, hypertension, occupational noise exposure, and creatinine-corrected urine VOC metabolite concentrations from the eighth Korea National Health and Nutrition Survey. Among the VOC metabolites, N-acetyl-S-(benzyl)-L-cysteine (BMA, P = 0.004), N-acetyl-S-(phenyl)-l-cysteine (SPMA, P = 0.027), and N-acetyl-S-(3,4-dihydroxybutyl)-l-cysteine (DHBMA, P < 0.001) showed associations with HL. Additionally, HFHL exhibited significant associations with BMA (P = 0.005), 3- and 4-methylhippuric acid (3, 4 MHA, P = 0.049), mandelic acid (MA, P = 0.015), SPMA (P < 0.001), N-acetyl-S-(3-hydroxypropyl)-l-cysteine (3-HPMA, P < 0.001), and DHBMA (P < 0.001). After controlling other factors, DHBMA were associated with HL (P = 0.021) and HFHL (P = 0.014) and exhibited a linear association with the mean hearing level (β = 0.054, P = 0.024) and high-frequency hearing level (β = 0.045, P = 0.037). Since 1,3-butadiene may act as an ototoxic material, early screening for workers exposed to 1,3-butadiene and reducing exposure to 1,3-butadiene in everyday life may be helpful to prevent further HL.

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