Exploring the dynamics and interplay of human papillomavirus and cervical tumorigenesis by integrating biological data into a mathematical model

Abstract

Background: Cervical cancer is the fourth most common tumor in women worldwide, mostly resulting from highrisk human papillomavirus (HR-HPV) with persistent infection. Results: The present discoveries are comprised of the following: (i) A total of 16.64% of the individuals were positive for HR-HPV infection, with 13.04% having a single HR-HPV type and 3.60% having multiple HR-HPV types. (ii) Cluster analysis showed that the infection rate trends of HPV31 and HPV33 in all infections as well as HPV33 and HPV35 in single infections in precancerous stages were very similar. (iii) The single/multiple infection proportions of HR-HPV demonstrated a trend that the multiple infections rates of HR-HPV increased as the disease developed. Conclusions: The HR-HPV prevalence in outpatients was 16.64%, and the predominant HR-HPV types in the study were HPV52, HPV58 and HPV16. HR-HPV subtypes with common biological properties had similar infection rate trends in precancerous stages. Especially, as the disease development of precancer evolved, defense against HPV infection broke, meanwhile, the potential of more HPV infection increased, which resulted in increase of multiple infections of HPV.

MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction

“…To overcome these shortcomings, we will employ natural language processing technology 58 , 59 to improve manual update efficiency and use high-performance computing 60 , 61 , 62 to reduce the processing time for similarity computing. Finally, we will make MDCB as a highly integrated web-based MC-related data platform by integrating more advanced bioinformatics applications and algorithms 27 , 63 , 64 , 65 , 66 , 67 , 68 , 69 in the future.…”

Prevalence and Risk Factors of Infection with High Risk Human Papilloma Viruses among HIV-Positive Women with Clinical Manifestations of Tuberculosis in a Middle-Income Country

“…An interesting finding in the context is a gender disparity between HR HPV types among sexually active adolescents and young adults in Brazil, with HPV 59 prevalent in men, and HPV 16, in women (despite introduction of HPV vaccination of girls in 2014) [ 106 ]. Another disparity between HR HPV types was uncovered in relation to the geographic origins of the study participants, with HPV 52 prevailing among Chinese women living in urban, and ‘old-fashioned’ HPV 16, among women living in the rural areas [ 107 ]. The latest data by Wu W et al demonstrated an increase in the prevalence in China of HR HPV of types 52 and 58, prevailing over HPV 16 [ 108 ].…”

Development of an Early Prediction Model for Subarachnoid Hemorrhage With Genetic and Signaling Pathway Analysis

“…Then, we used Robust Multi-chip Analysis (RMA) (Irizarry et al, 2003) for data preprocessing, including background and perfect match probes (PM) correction, normalization, and summarization, to obtain the probe expression data matrix (Table S1). Finally, clustering analysis (Liu et al, 2019;Xiao et al, 2019;Zhang et al, 2019c;Wu and Zhang, 2020) ( Figure S3) shows that the major differences between the chip of each group comes from SAH.…”