2021
DOI: 10.7759/cureus.13283
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Exploring the Effect of Metformin to Lower Thyroid-Stimulating Hormone in Euthyroid and Hypothyroid Type-2 Diabetic Patients

Abstract: Introduction Metformin is one of the safest, first-line oral hypoglycemic agents used in type-2 diabetes mellitus patients. This study aims to study the effect of metformin on thyroid-stimulating hormone (TSH) in hypothyroid and euthyroid individuals, as both these diseases have an increased prevalence and coexistence. Method This hospital-based study was conducted in Jinnah Allama Iqbal Institute of Diabetes and Endocrinology (JAIDE), Allama Iqbal Medical College/Jinnah Hospital Lahore, Pakistan, from October… Show more

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Cited by 9 publications
(15 citation statements)
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“…The results showed a significant reduction in TSH levels only in patients with T2DM and hypothyroidism, either treated or untreated. Furthermore, after metformin treatment, no significant variations were found in serum FT4 levels and the BMI did not change significantly, confirming that metformin acts regardless of the weight loss it may induce [ 8 ]. In the same line, a cross-sectional study by Díez & Iglesias examining 828 euthyroid patients with T2DM did not find any relationship between TSH values and metformin treatment in euthyroid T2DM patients [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The results showed a significant reduction in TSH levels only in patients with T2DM and hypothyroidism, either treated or untreated. Furthermore, after metformin treatment, no significant variations were found in serum FT4 levels and the BMI did not change significantly, confirming that metformin acts regardless of the weight loss it may induce [ 8 ]. In the same line, a cross-sectional study by Díez & Iglesias examining 828 euthyroid patients with T2DM did not find any relationship between TSH values and metformin treatment in euthyroid T2DM patients [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…Vigersky and colleagues were the first to randomly evaluate a possible link between metformin and TSH serum levels in hypothyroid patients on levothyroxine (LT4) treatment [ 6 ]. Since then, various studies have been published, mainly to corroborate or reject its effect on thyroid function [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Most of these studies were of prospective or retrospective design and some included only a limited number of patients.…”
Section: Introductionmentioning
confidence: 99%
“…Administered to individuals with elevated thyrotropin concentrations, metformin reduced thyrotropin levels and this effect was observed in subjects with thyroid hypofunction of autoimmune and non‐autoimmune origin, 1–6 iatrogenic hypothyroidism 7–9 and resistance to thyroid hormone 10 . The thyrotropin‐lowering effect of this agent was absent in euthyroid subjects 1,2,6,7 . The effect on thyrotrope function was not paralleled by the changes in total and free thyroid hormones.…”
Section: What Is Known and Objectivementioning
confidence: 99%
“…5 0 -adenosine monophosphate-activated protein kinase, hypothalamic-pituitary-thyroid axis, metformin, statins Overactive anterior pituitary thyrotropes are target cells for metformin, [1][2][3][4][5][6][7][8][9][10] a ubiquitously prescribed insulin sensitizer, useful in type 2 diabetes and related insulin resistance states. 11 Thyroid hormone deficiency with increased thyrotropin concentration is more commonly observed in patients with type 2 diabetes and other insulin resistance states than in the general population.…”
Section: Introductionmentioning
confidence: 99%
“…In these reports, patients with already established diagnosis were included, which preclude any definitive conclusion regarding the sole influence of the T2DM on thyroid morphology and function. Also, commonly used metformin and frequently employed procedures such as exposure to iodinated contrast material in this patient group might possibly alter thyroid function and morphology [6]. Up to now, no study was performed to evaluate thyroid morphological alterations in patients with newly diagnosed IFG and T2DM in iodine deficient area.…”
Section: Introductionmentioning
confidence: 97%