Exploring the feasibility of a mild and short 4-week combined upper limb and breathing exercise program as a possible home base program to decrease fatigue and improve quality of life in ambulatory and non-ambulatory multiple sclerosis individuals

Kezele, Tanja Grubić; Babić, Matea; Štimac, Dinko

doi:10.1007/s10072-019-3707-0

Cited by 17 publications

(26 citation statements)

References 37 publications

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“…some studies, specifically the blinding of the personnel evaluating the patients and the unclear risk of bias for the concealment of random assignment (See figure 3). Some studies had an unclear risk of bias in the generation of the random sequence secondary to the mention of the method, but how this sequence is performed is not explained (Grubić et al, 2019;Park & Lee, 2019;Phattharasupharerk et al, 2019;wongwilairat et al, 2018) (See figure 3).…”

Section: Studies Excludedmentioning

confidence: 99%

Breathing technique in pain and cognitive function: a systematic review of the literature

Alzate-Granados

Solarte

López

et al. 2020

JACN

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Breathing techniques are key components of yoga, meditation and relaxation practices that are well known for reducing anxiety and improving overall well-being. To evaluate the efficacy of breathing techniques in pain and cognitive function. We conducted a literature review searching the main literature databases (medline, lilacs, Cochrane library) including randomized clinical trials. We assessed the risk of bias of the included studies using the methodology proposed by the Cochrane collaboration. In total, we found 16 studies that met the inclusion criteria, with an intermediate or unclear overall risk of bias. When combining the different breathing techniques vs control in the included studies, we found a statistically significant difference in terms of the visual analog scale (Difference of means, random effects; -1.21 [95% CI -1.75 to -0.68]; I2: 95%). Meditation-based breathing techniques would improve pain and cognitive function in patients with a painful entity or healthy volunteers.

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Section: Studies Excludedmentioning

confidence: 99%

Breathing technique in pain and cognitive function: a systematic review of the literature

Alzate-Granados

Solarte

López

et al. 2020

JACN

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“…The fatigue in MS patients represents leading initial motivational barrier for further exercise at home alone by themselves and, we assume, it could be easily over passed with continuous mild and stress less exercise program providing more motivation for MS patients. 25 Regarding fatigue, MS individuals are characterized by reduced exercise tolerability and muscle weakness, often leading to decreased motivation and physical inactivity. 26 This was the main reason to see was there any improvement in MS patients fatigue, especially in those with Expanded Disability Status Scale (EDSS) from 6-8, after mild stress less exercise but with an accent on breathing exercise in a short time.…”

Section: Discussionmentioning

confidence: 99%

“…Based on our preliminary positive results in a pilot study with MS individuals (EDSS 0-8) we can assume that content of exercise program and its duration pro session is important to carry out this goal. 25 The pilot study was designed to verify feasibility of an upper limbs and breathing exercise and to explore possible effects on fatigue and the QOL in a group of ambulatory and nonambulatory individuals with MS for the future larger trial. Ambulatory and non-ambulatory individuals could successfully complete this exercise program without exacerbation of MS.…”

Section: Discussionmentioning

confidence: 99%

“…The pilot study involved exercise program with respiratory muscle involvement for 10 minutes in the beginning and in the end of each session, exercise for coordination and amplitude, and combination of strengthening exercise for upper limbs, 2 times a week for 1 hour in a group led by the physiotherapist in the MS Center, and at home alone in between. The precise exercise protocol can be found in reference from Grubić Kezele et al 25 For measuring fatigue and psychophysical functioning before and after exercise we propose Modified Fatigue Impact Scale (MFIS) and RAND Medical outcomes study 36-item short-form health survey (SF-36).…”

Section: Discussionmentioning

confidence: 99%

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Mild and motivational exercise in social supporting environment for over passing primary fatigue in patients with multiple sclerosis

Kezele

Fužinac-Smojver

Kauzlarić-Živković

2019

IPMRJ

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The most common symptom displayed in patients with multiple sclerosis (MS) is a pronounced sense of fatigue that can have negative effect on functional ability and quality of life (QOL). An important goal of researchers and clinicians involves improving the QOL of individuals with MS and the exercise therapy represents potentially modifiable behavior that positively impacts on pathogenesis of MS and thus the QOL. Citation: Kezele TG, Fužinac-Smojver A, Kauzlarić-Živković T. Mild and motivational exercise in social supporting environment for over passing primary fatigue in patients with multiple sclerosis. Int Phys Med Rehab J. 2019;4(4):152-154.

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“…An animal test showed that oxygen breathing affects adipose through air bubble [18,19]. Breath exercise can reduce HR [20] and BP [21] and increase QoL [22] and may have the protective function for the patients after PCI by affecting adipose.…”

Section: Introductionmentioning

confidence: 99%

Tai Chi Improves Coronary Heart Disease Risk by Inactivating MAPK/ERK Pathway through Serum miR‐126

Zhang

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Tai Chi is effective in preventing heart disease (CHD) risk, but the molecular mechanism remains unclear. Mitogen-activated protein kinase (MAPK) signaling plays a critical role in the pathogenesis of CHD and can be activated by miR-126. Tai Chi may exert its protective function through the miR-126-modulated MAPK pathway. Methods. The CHD patients after PCI were randomized into the CG group (CG) (n = 19, normal care) and Tai Chi group (TG) (Tai Chi intervention, n = 17). Epicardial adipose tissue volume (EATV) (one main adverse cardiovascular event of CHD), HR (heart rate), QoL (quality of life) scores, and balance performance were measured in the two groups. The body fat content, abdominal subcutaneous fat, and visceral fat were measured to reflect the improvement of adipose tissue dysfunction. The levels of miR-126 and MAPK-associated molecules were measured in peripheral blood leukocytes. Meanwhile, the effects of miR-126 silence and mimic on MAPK-associated molecules were also explored in cardiac cell H9C2. Results. After the 3-month intervention, Tai Chi reduced EATV and HR and increased QoL scores and balance performance, respectively (P<0.05). The fat percentage, body fat mass, and BMI were also significantly reduced after Tai Chi intervention (P<0.05). The levels of miR-126, MAPK, JNK, and ERK in the TG group were lower than those in the CG group (P<0.05). The miR-126 levels had a strong relationship with the values of EATV, HR, and QoL scores (P<0.05). miR-126 silence or mimic inactivated or activated MAPK-associated molecules in the cardiac cell lines. Conclusions. Tai Chi improved CHD risk by inactivating the MAPK/ERK pathway via serum miR-126.

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Exploring the feasibility of a mild and short 4-week combined upper limb and breathing exercise program as a possible home base program to decrease fatigue and improve quality of life in ambulatory and non-ambulatory multiple sclerosis individuals

Cited by 17 publications

References 37 publications

Breathing technique in pain and cognitive function: a systematic review of the literature

Breathing technique in pain and cognitive function: a systematic review of the literature

Mild and motivational exercise in social supporting environment for over passing primary fatigue in patients with multiple sclerosis

Tai Chi Improves Coronary Heart Disease Risk by Inactivating MAPK/ERK Pathway through Serum miR‐126

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