P re-pandemic, the prevalence of mental illness was estimated at 1 in 5 adults, 1 and the US was facing an opioid epidemic. 2 Despite the high prevalence of mental health concerns and substance use disorders, numerous barriers to treatment and systematic limitations, including a shortage of professionals, limited access, lack of adequate funding, and stigma meant that as many as 70% of people with these conditions never sought treatment. 3,4 The cumulative and profound physical, psychological, economic, and social toll of the COVID-19 pandemic has exacerbated the mental health and substance use crisis in America. 4 As Czeisler et al. comprehensively outline in the opening article of this issue of Knowing Well, Being Well, there has already been a very significant adverse impact on mental health. By mid-July, more than 50% of American