Exploring the molecular mechanisms of isoliquiritin extraction using choline chloride-citric acid deep eutectic solvents

Hu, Yi; Wang, Zhuxian; Liang, Peiyi; Zhu, Hongxia; Qiang, Liu

doi:10.1016/j.scp.2023.101099

Cited by 10 publications

(7 citation statements)

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“…RDF is a probability density distribution of finding another particle at a distance r in a system composed of atoms, molecules, or ions, which describes the density distribution of surrounding atoms or molecules at a distance r and can be used to describe the interaction between atoms, molecules, or ions in solids, liquids, or gases. 57–59 Generally, when the peak of g ( r ) is less than 3.5 Å, it indicates that hydrogen bonds are formed between molecules. 44 As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

Liang,

Hu,

Wang

et al. 2023

CrystEngComm

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Section: Resultsmentioning

confidence: 99%

Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

Liang,

Hu,

Wang

et al. 2023

CrystEngComm

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“…Deep eutectic solvent mixtures are formed by mixing two or more components in the appropriate molar ratio in the presence of heat. Additionally, this process does not require an additional purification step [ 236 , 237 ]. Deep eutectic solvents are one of the most promising discoveries in “green chemistry”.…”

Section: Application Of Citric Acid In the Food Industrymentioning

confidence: 99%

“…HBAs are mainly quaternary ammonium or phosphonium salts, while HBDs are most commonly amides, alcohols, and carboxylic acids. Citric acid is one of the most commonly employed HBDs among carboxylic acids [ 237 ]. The most popular systems for producing deep eutectic solvents using choline chloride and citric acid are 1:1, 1:2, and 2:1 [ 241 , 242 ].…”

Section: Application Of Citric Acid In the Food Industrymentioning

confidence: 99%

“…The results indicated that deep eutectic solvents exhibited higher efficiency in isoliquiritigenin extraction as an extraction solvent than ethanol with water. Additionally, the increased efficiency in isoliquiritigenin extraction was primarily attributed to the strong interaction between isoliquiritigenin and the extraction solvent and the rapid diffusion of isoliquiritigenin [ 237 ].…”

Section: Application Of Citric Acid In the Food Industrymentioning

confidence: 99%

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Citric Acid: Properties, Microbial Production, and Applications in Industries

Książek

2023

Molecules

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Citric acid finds broad applications in various industrial sectors, such as the pharmaceutical, food, chemical, and cosmetic industries. The bioproduction of citric acid uses various microorganisms, but the most commonly employed ones are filamentous fungi such as Aspergillus niger and yeast Yarrowia lipolytica. This article presents a literature review on the properties of citric acid, the microorganisms and substrates used, different fermentation techniques, its industrial utilization, and the global citric acid market. This review emphasizes that there is still much to explore, both in terms of production process techniques and emerging new applications of citric acid.

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“…Licorice favonoids are a class of favonoid compounds extracted from licorice roots [7]. Tey are widely used in traditional Chinese medical and other herbal formulations, exhibiting various biological activities, with antioxidant activity being one of the most prominent and important features [8].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Molecular Mechanism of the Antioxidant Activity of Medicine and Food Homology Licorice Flavonoids Based on Pharmacophore Theory and Quantum Calculations

Hu,

Liang,

Wang

et al. 2023

Journal of Food Biochemistry

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Licorice flavonoids are a kind of flavonoids extracted from the root of licorice, which have good antioxidant activity and are widely used in the food industry. In the early research of the research group, it has been found that the antioxidant activity of licorice flavonoids can be altered by solvent mediation. However, the molecular mechanism underlying the antioxidant properties of licorice flavonoids is still not fully understood. Therefore, this study aims to explore the molecular mechanism underlying the antioxidant activity of licorice flavonoids based on the principles of pharmacophore theory and quantum computing. Firstly, network pharmacology will be employed to study the antioxidant properties of licorice flavonoids. The major active components and key structural features responsible for the antioxidant activity in licorice flavonoids will be screened using pharmacophore theory and further validated through molecular docking. Lastly, quantum computing will be utilized to uncover the potential mechanism underlying their antioxidant activity. Pharmacophore studies have shown that licochalcone B, retrochalcone, isoliquiritin, and isoliquiritigenin exhibit low predicted IC50 values, indicating that these compounds are key components of licorice flavonoids in the antioxidant process. Molecular electrostatic potential (MEP) and frontier molecular orbital studies have shown that licochalcone B, retrochalcone, isoliquiritin, and isoliquiritigenin all exhibit certain chemical reactivity. Quantum computing studies have found that the para-phenol hydroxyl group on the core structure of licochalcone B, isoliquiritigenin, retrochalcone, and isoliquiritin is a crucial functional group for the antioxidant activity of flavonoid compounds. In general, this study successfully elucidated the mode of action of licorice flavonoids in the antioxidant process, providing some guidance for the synthesis of new antioxidant compounds.

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Exploring the molecular mechanisms of isoliquiritin extraction using choline chloride-citric acid deep eutectic solvents

Cited by 10 publications

References 53 publications

Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

Citric Acid: Properties, Microbial Production, and Applications in Industries

Exploring the Molecular Mechanism of the Antioxidant Activity of Medicine and Food Homology Licorice Flavonoids Based on Pharmacophore Theory and Quantum Calculations

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