Exploring the nephrotoxicity of sulfur-containing derivatives in sulfur-fumigated Panacis Quinquefolii Radix based on chemical profiling and untargeted metabolomics

He, Jinjin; Jiang, Jun; Xie, Ting; Liu, Yuan; Cai, Hui; Xiao, Shichang; Cai, Zhihui; Chen, Tong

doi:10.1016/j.jep.2022.115773

Cited by 3 publications

(1 citation statement)

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“…Metabolomics is a powerful tool for obtaining comprehensive information regarding the biochemical constituents of a biological system [9,10], and has shown unique advantages in the study of pharmaceuticals [11][12][13] and food science [14,15] field. UHPLC-quadrupole/orbitrap HRMS (UHPLC-Q-Orbitrap HRMS) is one of the most widely employed analytical tools in metabolomics studies [16], because of the efficient separation capabilities of UHPLC and excellent structural elucidation by HRMS [17].…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography‐mass spectrometry‐based metabolomics reveals the comprehensive metabolites in Dioscorea opposita Thunb. peel

Yang

Zhai

Zhang

et al. 2023

Separation Science Plus

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Dioscorea opposita Thunb., a traditional medicinal and food homologous plant, has been used for thousands of years in folk medicine and nutritious food, partially due to the metabolites. However, detailed information on the metabolites in Dioscorea opposita Thunb. peel is still scarce. Herein, an ultra‐high‐performance liquid chromatography‐quadrupole/orbitrap high‐resolution mass spectrometry‐based metabolomics approach was used to reveal the comprehensive metabolites in Dioscorea opposita Thunb. peel. The proposed method provided tentative identification of 307 metabolites. Among them, 286 metabolites are reported herein in Dioscorea opposita Thunb. peel for the first time, namely: 87 lipids, 49 phenolic acids, 34 flavonoids, 29 amino acids and derivatives, 28 organic acids, 14 alkaloids, 10 lignans, and coumarins, eight saccharides and vitamins, six nucleotides and derivatives, two quinones, and 19 others. The obtained results highlight the importance of Dioscorea opposita Thunb. peel as a promising source of bioactive ingredients, and form a basis for future quantitative and bioavailability studies.

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