Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations

Tablet disintegration performance: Effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics

“…True density, particle size and shape values for all excipients are summarised in Section S1 and Table S1 in the Supporting Information. Dynamic vapour sorption isotherms and single particle dissolution rates (mannitol and lactose only) can also be found in Maclean et al (2020).…”

“…The compression pressures used are shown in Table 1 for each formulation. More details about the tensile strength and the porosity measurements can be found in Maclean et al (2020).…”

“…The liquid absorption behaviour of the formulations containing MCC, DCPA and lactose is primarily driven by the surface energy of the excipients and the pore structure of the compact. The mannitol based formulation is also influenced by the rapid dissolution of the mannitol that increases the available pore space and hence accelerates the liquid absorption process (Maclean et al, 2020).…”

“…This is primarily attributed to a decrease in pore space in the lower pressure compacts, where the swelling of particles is more rapidly observed on the tablet surface due to the limited swelling of these particles into the pore space. On the contrary, an increase in 1/A could be impact the disintegration time as this formulation is controlled by the liquid absorption process (Maclean et al, 2020). The disintegration performance of such a formulation is mainly influenced by changes that affect the liquid absorption (e.g.…”

“…For example, a disintegration process which is primarily influenced by its liquid uptake rate is highly sensitive to changes in tablet porosity (e.g. a MCC/lactose-based formulation) (Maclean et al, 2020), which should thus be tightly controlled during manufacturing.…”