Exploring the Potential of Mesenchymal Stem Cell–Derived Exosomes for the Treatment of Alopecia

Ajit, Amita; Meera, Nair; Venugopal, Balaji

doi:10.1007/s40883-021-00204-3

Cited by 8 publications

(12 citation statements)

References 71 publications

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“…A new strategy for androgenetic alopecia treatment to restore the hair follicles cycle is considered. MSC-EVs contain various growth factors and cytokines, which can be involved in hair regeneration [ 212 ]. They promote de novo morphogenesis of hair follicles and the dermal papilla formation, a vital component modulating follicle cell activity in hair regeneration via Wnt signaling [ 213 ].…”

Section: Therapeutical Application Of Extracellular Vesicles For Skin Wound Healingmentioning

confidence: 99%

“…TGF signaling cascades lead to hair follicle down-growth and hair follicle shape development [ 214 ]. Stem cell-secreted EVs also modulate hair re-growth through Fgf, Bmp, Shh, Notch signaling pathways, followed by dermal condensate (accumulation of stem cells) formation, activation and promotion of placode formation (spaced thickenings in the epidermis), and differentiation of hair shaft [ 212 ].…”

Section: Therapeutical Application Of Extracellular Vesicles For Skin Wound Healingmentioning

confidence: 99%

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Extracellular Vesicles in Skin Wound Healing

et al. 2021

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Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Such an extensive involvement of EVs suggests exploiting their action to modulate the impaired healing phase. Furthermore, next to their natural wound healing capacity, EVs can be engineered for better defined pharmaceutical purposes, such as carrying specific cargo or targeting specific destinations by labelling them with certain surface proteins. This review aims to promote scientific awareness in basic and translational research of EVs by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration, and treatment of dermal diseases, including the stem cell-derived, plant-derived, and engineered EVs.

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Section: Therapeutical Application Of Extracellular Vesicles For Skin Wound Healingmentioning

confidence: 99%

Section: Therapeutical Application Of Extracellular Vesicles For Skin Wound Healingmentioning

confidence: 99%

Extracellular Vesicles in Skin Wound Healing

et al. 2021

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“…Additionally, bone marrow‐derived exosomes were shown to activate dermal papillae cell proliferation and migration, upregulation of the Wnt/ β ‐catenin pathway, and increase secretion of growth factors 28 . Separately, exosomes from human dermal fibroblasts have been shown to activate the β‐catenin pathway in cell culture 29,30 …”

Section: Resultsmentioning

confidence: 99%

Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Kost

Muskat

Mhaimeed³

et al. 2022

J of Cosmetic Dermatology

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Background: Alopecia is a common chief complaint and is challenging to treat. As such, regenerative treatments to promote hair growth are an emerging area of research. Exosomes, which are extracellular vesicles involved in cell communication, homeostasis, differentiation, and organogenesis, have been shown to play a central role in hair morphogenesis and regeneration with potential for use as alopecia treatment.Aims: This review summarizes and assesses the body of literature surrounding exosomes as regenerative therapeutics for alopecia and identifies areas for improvement in future research.Methods: A review was conducted using a comprehensive list of keywords including "exosome," "alopecia," and "hair loss" on PubMed, EMBASE, and Google Scholar databases published from inception to February 2022. Reference lists of identified articles were included. 47 studies were included. Clinical trial databases were searched using the term "exosome"; however, no trials relevant to hair growth were identified.Results: Our updated and comprehensive review details the history of exosome use in medicine, postulated underlying mechanisms in treating hair loss, and current clinical studies. Preclinical studies demonstrate clear benefits of exosome therapeutics in regenerative medicine and for hair loss treatment. Clinical trials demonstrate safety of exosome use in medicine, but data showing efficacy and safety of exosome therapy for alopecia are lacking. We identified several gaps in knowledge required for effective clinical translation including safety, exosome source, and optimal treatment delivery mechanism and dosage. Conclusion:Exosomes are on the horizon as an exciting therapeutic for the treatment of alopecia. Further studies and clinical trials are required.

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“…A new strategy for allogenic alopecia treatment to restore the hair follicles cycle is considered. MSC-EVs contain various growth factors and cytokines, which can be involved in hair regeneration [200]. They promote de novo morphogenesis of hair follicles and the dermal papilla formation, a vital component modulating follicle cell activity in hair regeneration via Wnt signalling [201].…”

Section: Application Of Extracellular Vesicles For Treatment Of Dermal Diseasesmentioning

confidence: 99%

“…TGF signalling cascades lead to hair follicle down-growth and hair follicle shape development [202]. Stem cell-secreted EVs also modulate hair re-growth through Fgf, Bmp, Shh, Notch signalling pathways, following with dermal condensate (accumulation of stem cells) formation, activation and promotion of placode formation (spaced thickenings in the epidermis) and differentiation of hair shaft [200].…”

Section: Application Of Extracellular Vesicles For Treatment Of Dermal Diseasesmentioning

confidence: 99%

Extracellular Vesicles in Skin Wound Healing

Narauskaitė

Vydmantaitė

Rusteikaitė

et al. 2021

Preprint

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Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signalling takes part in all four wound healing phases: hemostasis, inflammation, proliferation and remodelling. Such an extensive involvement of EVs suggests exploiting their action to modulate the impaired healing phase. Furthermore, next to their natural wound healing capacity, EVs can be engineered for better defined pharmaceutical purposes, such as carrying specific cargo or targeting specific destinations by labelling them with certain surface proteins. This review aims to promote scientific awareness in basic and translational research of EVs by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration and treatment of dermal diseases, including the stem cell-derived, plant-derived and engineered EVs.

show abstract

Exploring the Potential of Mesenchymal Stem Cell–Derived Exosomes for the Treatment of Alopecia

Cited by 8 publications

References 71 publications

Extracellular Vesicles in Skin Wound Healing

Extracellular Vesicles in Skin Wound Healing

Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Extracellular Vesicles in Skin Wound Healing

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