Exploring the synthesis conditions to control the morphology of gold-iron oxide heterostructures

Tancredi, Pablo; Costa, Luelc Souza da; Calderón, Sebastián; Londoño, Oscar Moscoso; Socolovsky, L.M.; Ferreira, Paulo J.; Muraca, Diego; Zanchet, Daniela; Knobel, M.

doi:10.1007/s12274-019-2431-7

Cited by 21 publications

(27 citation statements)

References 49 publications

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“…With this idea, nanoparticles possessing different properties are beginning to be combined into new materials by their conjugation to obtain products that are suitable for complex applications in theranostic nanomedicine. In particular, core-shell magnetic nanoparticles (MNPs) are combined with gold (Au) [3], silver (Ag) [4] and titanium oxide (TiO 2 ) [5] nanoparticles in order to obtain nanoconjugates with specific properties of the two types of nanoparticles. In this respect, core-shell magnetic nanoparticles (MNPs) can be successfully used as agents for transport and delivery (at the desired site) of an antioxidant drug capable of inactivating reactive oxygen species (ROS) and/or reactive nitrogen species (RNS), hindering the side effects that may occur, such as DNA mutations and lipid peroxidation [6,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Turin-Moleavin¹,

Fifere²,

Lungoci³

et al. 2019

Nanomaterials

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Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and the occurrence of genetic mutations that can cause cancer. This study presents the synthesis and biological characterisation of nanoconjugates based on nanoparticles of iron oxide interconnected with cerium oxide conjugates. Methods. The synthesis of magnetite-nanoceria nanoconjugates has been done in several stages, where the key to the process is the coating of nanoparticles with polyethyleneimine and its chemical activation-reticulation with glutaraldehyde. The nanoconjugates are characterised by several techniques, and the antioxidant activity was evaluated in vitro and in vivo. Results. Iron oxide nanoparticles interconnected with cerium oxide nanoparticles were obtained, having an average diameter of 8 nm. Nanoconjugates prove to possess superparamagnetic properties and the saturation magnetisation varies with the addition of diamagnetic components in the system, remaining within the limits of biomedical applications. In vitro free-radical scavenging properties of nanoceria are improved after the coating of nanoparticles with polyethylenimine and conjugation with magnetite nanoparticles. In vivo studies reveal increased antioxidant activity in all organs and fluids collected from mice, which demonstrates the ability of the nanoconjugates to reduce oxidative stress. Conclusion. Nanoconjugates possess magnetic properties, being able to scavenge free radicals, reducing the oxidative stress. The combination of the two properties mentioned above makes them excellent candidates for theranostic applications.

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Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Turin-Moleavin¹,

Fifere²,

Lungoci³

et al. 2019

Nanomaterials

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“…14 Some efforts have been devoted to identifying the main factors that determine the synthesis of iron oxide-metal (Au or Ag) HNPs. 34,[87][88][89] For example, Guardia et al focused on the behavior of Au/Fe-oxide dimers in magnetic hyperthermia experiments 89 and found that chloride ions can promote the nucleation of iron oxide on the Au NP surface. This strategy was exploited to tune the size and shape of the Janus HNPs, and large heating powers were reported for Fe-oxide domains of 24 nm.…”

Section: C Hybrid Nanostructures To Functionalize or Passivate Chemically-unstable Coresmentioning

confidence: 99%

Hybrid magnetic nanoparticles as efficient nanoheaters in biomedical applications

et al. 2021

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“…Core–shell nano-heterostructures based on iron and gold can be prepared via a seed-assisted method by the incorporation of a reducing agent and slowing down the heating process [ 79 ].…”

Section: Iron–gold Bifunctional Nanoparticlesmentioning

confidence: 99%

“…This method is different than the multi-nucleation event, where the incorporation of a reducing agent or decreasing the reaction temperature leads to the formation of core–shell structures. However, increasing the size of Au seed to 8 nm yields to a flower-like structure [ 79 ].…”

Section: Iron–gold Bifunctional Nanoparticlesmentioning

confidence: 99%

Recent Advances in the Use of Iron–Gold Hybrid Nanoparticles for Biomedical Applications

2021

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Recently, there has been an increased interest in iron–gold-based hybrid nanostructures, due to their combined outstanding optical and magnetic properties resulting from the usage of two separate metals. The synthesis of these nanoparticles involves thermal decomposition and modification of their surfaces using a variety of different methods, which are discussed in this review. In addition, different forms such as core–shell, dumbbell, flower, octahedral, star, rod, and Janus-shaped hybrids are discussed, and their unique properties are highlighted. Studies on combining optical response in the near-infrared window and magnetic properties of iron–gold-based hybrid nanoparticles as multifunctional nanoprobes for drug delivery, magnetic–photothermal heating as well as contrast agents during magnetic and optical imaging and magnetically-assisted optical biosensing to detect traces of targeted analytes inside the body has been reviewed.

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Exploring the synthesis conditions to control the morphology of gold-iron oxide heterostructures

Cited by 21 publications

References 49 publications

In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Hybrid magnetic nanoparticles as efficient nanoheaters in biomedical applications

Recent Advances in the Use of Iron–Gold Hybrid Nanoparticles for Biomedical Applications

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