Exploring the therapeutic potential of omega-3 fatty acids in depression

Sikka, Priyanshi; Behl, Tapan; Sharma, Sanchay; Sehgal, Aayush; Bhatia, Saurabh; Al‐Harrasi, Ahmed; Singh, Sukhbir; Sharma, Neelam; Aleya, Lotfi

doi:10.1007/s11356-021-14884-5

Cited by 11 publications

(8 citation statements)

References 92 publications

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“…Another study reported that, an add-on therapy of omega-3 has significantly improvized the clinical functioning of sertraline and in addition, Antidepressant effects were amplified by combining antidepressant drugs with dietary and physiological supplements. It is also reported that, when compared to antidepressants alone, adding omega-3 fatty acids in the management of depression was effective and successful with few negative effects [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study

Mehdi

Manohar

Shariff

et al. 2023

JPM

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Depression is a common mood disorder characterized by persistent sadness and loss of interest. Research suggests an association between the inclusion of omega-3 fatty acids in the diet and a reduced risk for depression. The present study evaluated the effectiveness of omega-3 fatty acid supplements in alleviating depressive symptoms in patients with mild to moderate depression. A total of 165 patients suffering from mild to moderated depression were randomized to receive omega-3 fatty acid supplementation, an antidepressant (single agent), or a combination of an antidepressant and omega-3 fatty acid supplementation. The clinical features of depression were assessed using the Hamilton Depression Rating Scale (HDRS) during the follow-up period. A statistically significant improvement in depressive symptoms was observed from baseline to first, second and third follow-ups within each treatment arm as measured by HRDS scores (p = 0.00001). Further, the HDRS scores at the third follow-up were significantly lower in patients on combination therapy of omega-3 fatty acid supplement and antidepressants (arm-3) than the patients on the omega-3 fatty acid supplement alone (arm-1) [Q = 5.89; p = 0.0001] or the patients taking an antidepressant alone (arm 2) [Q = 4.36; p = 0.0068]. The combination of an omega-3 fatty acid supplement and an antidepressant elicited significantly higher improvement in depressive symptoms than the supplement or the antidepressant alone.

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Section: Introductionmentioning

confidence: 99%

Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study

Mehdi

Manohar

Shariff

et al. 2023

JPM

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“…Additionally, this is the first study to explore the relationship between E-DII score and depression among cancer survivors using NHANES, and this work also examine for the first time the association between the E-DII score, depression and mortality. Previous researchers have suggested that dietary supplementation with nutrients such as vitamin ( 65 , 66 ), minerals ( 67 ) and polyunsaturated fatty acids ( 68 , 69 ) could alleviate inflammation-related depression. The emerging field of nutritional epidemiology turns its attention to the relationship between dietary patterns and health outcomes, rather than focusing on specific nutrients or foods.…”

Section: Discussionmentioning

confidence: 99%

Dietary inflammatory index, and depression and mortality risk associations in U.S. adults, with a special focus on cancer survivors

Zhang

et al. 2022

Front. Nutr.

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IntroductionA higher risk for depression and mortality is associated with the inflammatory potential of diet measured through the Dietary Inflammatory Index (DII). The roles of DII in the risk of depression and death in cancer survivors were unclear. We aimed to examine the association between energy-adjusted DII (E-DII) score and risk of depression, and mortality using data from the 2007–2018 National Health and Nutrition Examination Survey (NHANES), with a special focus on cancer survivors.MethodsThe 24-h dietary recall interview was used as a basis to calculate the E-DII score and the Patient Health Questionnaire-9 (PHQ-9) was used to measure the depressive outcomes. Logistic regression analyses were performed to determine the association between quartiles of E-DII score and depression. Cox proportional hazard regression and competing risk analyses were used to estimate the risks of quartiles of E-DII score or depression on mortality.ResultsA total of 27,447 participants were included; including 24,694 subjects without cancer and 2,753 cancer survivors. The E-DII score and depression were not distributed differently between the two groups. However, the E-DII scores were positively associated with within each group’s depression (all P trend < 0.001) and participants with higher E-DII scores had a higher risk of depression (subjects without cancer: ORQ4vsQ1: 2.17, 95% CI: 1.75–2.70; cancer survivors: ORQ4vsQ1: 1.78, 95% CI: 1.09–2.92). The median follow-up time were 87 person-months, a total of 1,701 (4.8%) and 570 (15.2%) all-cause deaths in subjects without cancer and cancer survivors were identified by the end of 2019. The highest E-DII scores quartile was associated with the highest risk of all-cause (HRQ4vsQ1: 1.90, 95% CI: 1.54–2.35) and cardiovascular disease (CVD) cause death (HRQ4vsQ1: 2.50, 95% CI: 1.69–2.3.7) in the subjects without cancer. Moreover, participants with depressive symptoms had higher all-cause mortality (HR: 1.29, 95% CI: 1.04–1.59). No significant correlation was found for E-DII scores or depression with all-cause, cancer-cause or CVD-cause mortality in cancer survivors.ConclusionOur findings demonstrate that E-DII score was positively associated with depression risk. A higher E-DII score or depressive symptom may increase the risks of all-cause and CVD-cause mortality only among general subjects.

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“…It has been shown to have several health benefits, including reducing inflammation, improving heart health, and potentially reducing the risk of certain types of cancer [64,65]. EPA may also be beneficial for mental health, as it has been shown to reduce symptoms of depression and anxiety [66]. Additionally, EPA may have benefits for eye health, cognitive function, and immune system function [67].…”

Section: Effect Of Enteromorpha Hydrolysate Concentration On Growth A...mentioning

confidence: 99%

Saturated and Polyunsaturated Fatty Acids Production by Aurantiochytrium limacinum PKU#Mn4 on Enteromorpha Hydrolysate

Zhu

Ning

et al. 2023

Marine Drugs

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Thraustochytrids are unicellular marine heterotrophic protists, which have recently shown a promising ability to produce omega-3 fatty acids from lignocellulosic hydrolysates and wastewaters. Here we studied the biorefinery potential of the dilute acid-pretreated marine macroalgae (Enteromorpha) in comparison with glucose via fermentation using a previously isolated thraustochytrid strain (Aurantiochytrium limacinum PKU#Mn4). The total reducing sugars in the Enteromorpha hydrolysate accounted for 43.93% of the dry cell weight (DCW). The strain was capable of producing the highest DCW (4.32 ± 0.09 g/L) and total fatty acids (TFA) content (0.65 ± 0.03 g/L) in the medium containing 100 g/L of hydrolysate. The maximum TFA yields of 0.164 ± 0.160 g/g DCW and 0.196 ± 0.010 g/g DCW were achieved at 80 g/L of hydrolysate and 40 g/L of glucose in the fermentation medium, respectively. Compositional analysis of TFA revealed the production of equivalent fractions (% TFA) of saturated and polyunsaturated fatty acids in hydrolysate or glucose medium. Furthermore, the strain yielded a much higher fraction (2.61–3.22%) of eicosapentaenoic acid (C20:5n-3) in the hydrolysate medium than that (0.25–0.49%) in the glucose medium. Overall, our findings suggest that Enteromorpha hydrolysate can be a potential natural substrate in the fermentative production of high-value fatty acids by thraustochytrids.

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Exploring the therapeutic potential of omega-3 fatty acids in depression

Cited by 11 publications

References 92 publications

Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study

Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study

Dietary inflammatory index, and depression and mortality risk associations in U.S. adults, with a special focus on cancer survivors

Saturated and Polyunsaturated Fatty Acids Production by Aurantiochytrium limacinum PKU#Mn4 on Enteromorpha Hydrolysate

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