Exploring the utility of genetic markers for predicting biological age

Saeed, Maria; Berlin, Rebecca M.; Cruz, Tracey Dawson

doi:10.1016/j.legalmed.2012.05.003

Cited by 20 publications

(12 citation statements)

References 82 publications

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“…In this scenario, the term “perceived age” refers to the age that someone is visually estimated to have in relation to their chronological age. This concept has implications that go beyond mere aesthetics: perceived age is a robust biomarker of aging that predicts survival in certain groups of patients2 and correlates with important functional and molecular aging phenotypes 3…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments

Naval¹,

Alonso²,

Herranz³

2014

CCID

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IntroductionSkin changes are among the most visible signs of aging. Skin properties such as hydration, elasticity, and antioxidant capacity play a key role in the skin aging process. Skin aging is a complex process influenced by heritable and environmental factors. Recent studies on twins have revealed that up to 60% of the skin aging variation between individuals can be attributed to genetic factors, while the remaining 40% is due to non-genetic factors. Recent advances in genomics and bioinformatics approaches have led to the association of certain single nucleotide polymorphisms (SNPs) to skin properties. Our aim was to classify individuals based on an ensemble of multiple polymorphisms associated with certain properties of the skin for providing personalized skin care and anti-aging therapies.Methods and resultsWe identified the key proteins and SNPs associated with certain properties of the skin that contribute to skin aging. We selected a set of 13 SNPs in gene coding for these proteins which are potentially associated with skin aging. Finally, we classified a sample of 120 female volunteers into ten clusters exhibiting different skin properties according to their genotypic signature.ConclusionThis is the first study that describes the actual frequency of genetic polymorphisms and their distribution in clusters involved in skin aging in a Caucasian population. Individuals can be divided into genetic clusters defined by genotypic variables. These genotypic variables are linked with polymorphisms in one or more genes associated with certain properties of the skin that contribute to a person’s perceived age. Therefore, by using this classification, it is possible to characterize human skin care and anti-aging needs on the basis of an individual’s genetic signature, thus opening the door to personalized treatments addressed at specific populations. This is part of an ongoing effort towards personalized anti-aging therapies combining genetic signatures with environmental and life style evaluations.

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Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments

Naval¹,

Alonso²,

Herranz³

2014

CCID

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“…Brouilette et al (2007) and Salpea et al (2010) confirmed that oxidative stress conditions has been found to accelerate telomere shortening and has been linked to psychological disorders, diabetes, inflammation and vascular diseases. Saeed et al (2012) stated that despite the fact that many pathological diseases have been found to cause telomere shortening, the direct mechanisms for these effects remain unknown. Tsuji et al (2002) found that dried blood stains stored for 5 months revealed a mean TL 500 bp shorter than that of freshly drawn blood samples from the same individuals.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, there is no research report of systemic population about telomere shortening (Takasaki et al, 2003;Ren et al, 2009). Saeed et al (2012) confirmed that it is necessary to design basic science experiments for better evaluation of the role of TL in molecular prediction of biological age, as it remains the most promising biomarker for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Telomere Length Measurement by Quantitative Real-time PCR: A Molecular Marker for Human Age Prediction

Alhusseini¹,

Madboly²

2016

American Journal of Biochemistry and Biotechnology

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The fact that telomere shortening occurs with aging leads to the hypothesis that a correlation could be made between Telomere Length (TL) and suspect age. This study aimed to assess if TL can be used as an investigational tool to predict human age through developing a formula based on this correlation with accuracy suitable to be applied in forensic practice. A quantitative real-time PCR study was carried out on 80 Egyptians, ranging in age from 1-79 years. The results confirmed that the relative TL significantly shortened with aging; "r" = -0.903 (p<0.001). The human age could be determined by the following formula: (Y = 66.9-28X), (Y: Age in years; X: Relative TL), with a regression analysis between relative TL and age had an R 2 = 0.815. The standard error of age estimate was ±10.14 years. The present study concluded that estimation of human age based on the relative TL measured by quantitative real-time PCR may be a useful method for age prediction, especially when there is no morphologic information in the biological samples, but the estimated standard error of age prediction in this study was quite high (±10 years) to be used with certainty in forensic investigations. Inter-individual variations in TL and variability among the gender must be also considered when applying this method. So, this method could only give a rough estimation of age and it may be a complementary method for age estimation from soft tissues.

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“…Brouilette et al (2007) and Salpea et al (2010) confirmed that oxidative stress conditions has been found to accelerate telomere shortening and has been linked to psychological disorders, diabetes, inflammation, and vascular diseases. Saeed et al (2012) stated that despite the fact that many pathological diseases have been found to cause telomere shortening, the direct mechanisms for these effects remain unknown.…”

Section: Madboly Et Al mentioning

confidence: 99%

Telomere Length as a Molecular Biomarker for Human Age Prediction: A Quantitative Real-Time PCR Study Among Sample of Egyptians

Madboly

Alhusseini

Elazm

2015

Mansoura Journal of Forensic Medicine and Clinical Toxicology

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The fact that telomere shortening occurs with aging leads to the hypothesis that a correlation could be made between telomere length (TL) and suspect age. This study aimed to assess if TL can be used as an investigational tool to predict human age through developing a formula based on this correlation with accuracy suitable to be applied in forensic practice. A quantitative real-time PCR study was carried out on 80 Egyptians, ranging in age from 1-79 years. The results confirmed that the relative TL significantly shortened with aging; "r" =-0.903 (p < 0.001). The human age could be determined by the following formula: (Y= 66.9-28X), (Y: age in years; X: relative TL), with a regression analysis between relative TL and age had an R 2 = 0.815. The standard error of age estimate was ±10.14 years. The present study concluded that estimation of human age based on the relative TL measured by quantitative real-time PCR may be a useful method for age prediction, especially when there is no morphologic information in the biological samples, but the estimated standard error of age prediction in this study was quite high (±10 years) to be used with certainty in forensic investigations. Inter-individual variations in TL and variability among the gender must be also considered when applying this method. So, this method could only give a rough estimation of age and it may be a complementary method for age estimation from soft tissues.

show abstract

Exploring the utility of genetic markers for predicting biological age

Cited by 20 publications

References 82 publications

Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments

Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments

Telomere Length Measurement by Quantitative Real-time PCR: A Molecular Marker for Human Age Prediction

Telomere Length as a Molecular Biomarker for Human Age Prediction: A Quantitative Real-Time PCR Study Among Sample of Egyptians

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