Exploring ultrashort high-energy electron-induced damage in human carcinoma cells

Rigaud, O.; Fortunel, Nicolas O.; Vaigot, Pierre; Cadio, Emmanuelle; Martin, Michel; Lundh, Olle; Faure, Jérôme; Rechatin, Clément; Malka, Victor; Gauduel, Y.

doi:10.1038/cddis.2010.46

Cited by 63 publications

(48 citation statements)

References 15 publications

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“…This could benefit intensity modulated treatment where high lateral resolution is necessary. It has been shown that the range of energy, the charge per bunch, and the repetition rate of the laser satisfy many of the medical requirements for this application [84][85][86][87][88]. Monte Carlo calculations have been found to be in very good agreement with dose measurements.…”

Section: Laboratoire D'optique Appliquée-loa Palaiseau Francesupporting

confidence: 61%

“…They have published extensively in this area, researching: (a) radiotherapy with laser-plasma accelerators [84] both experimentally and using Monte Carlo simulation of deposited dose; and (b) measuring high energy electron induced damage in human carcinoma cells with electron bunches of ultrashort duration [85]. Treatment planning for laser accelerated very high energy electrons (now known as VHEE) has been carried out for prostate cancer and it has been found that the target coverage is better than that with a clinically approved 6 MV photon plan [86].…”

Section: Laser Driven Electron Beams For Radiotherapymentioning

confidence: 99%

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Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

et al. 2014

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It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumors. It has an innate ability to irradiate tumors with greater doses and spatial selectivity compared with electron and photon therapy and, hence, is a tissue sparing procedure. For more than twenty years, powerful lasers have generated high energy beams of protons and heavy ions and it has, therefore, frequently been speculated that lasers could be used as an alternative to radiofrequency (RF) accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realize its inherent enormous potential.

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Section: Laboratoire D'optique Appliquée-loa Palaiseau Francesupporting

confidence: 61%

Section: Laser Driven Electron Beams For Radiotherapymentioning

confidence: 99%

Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

et al. 2014

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“…The radiobiological effects at ultrahigh dose-rates and ultrashort timescales must be known, and initial experiments have been performed. 24 The feasibility of radiation therapy using laser-accelerated electrons has previously been studied in simulations. The dosimetric properties of laser-accelerated electrons were studied for low-energies in Refs.…”

Section: Introductionmentioning

confidence: 99%

Comparison of measured with calculated dose distribution from a 120‐MeV electron beam from a laser‐plasma accelerator

Lundh¹,

Rechatin²,

Faure³

et al. 2012

Medical Physics

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The measurements show that the high-energy electron beams produced by an optically injected laser-plasma accelerator can deliver high enough dose at penetration depths of interest for electron beam radiotherapy of deep-seated tumors. Many engineering issues must be resolved before laser-accelerated electrons can be used for cancer therapy, but they also represent exciting challenges for future research.

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“…There is a significant interest in radiotherapeutic application of electrons accelerated by high power lasers in gaseous targets. Laser‐plasma accelerators produce femtosecond electron bunches that are quasi mono‐energetic with energies in the range of tens of MeV up to a few GeV, and with a pulsed dose‐rate exceeding 10 13 Gy/s. Results have been recently reported on biological material irradiated with laser generated electrons both in vitro and in vivo.…”

Section: High Dose‐rate Radiation Sourcesmentioning

confidence: 99%

Laser‐driven radiation: Biomarkers for molecular imaging of high dose‐rate effects

et al. 2019

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Recently developed short‐pulsed laser sources garner high dose‐rate beams such as energetic ions and electrons, x rays, and gamma rays. The biological effects of laser‐generated ion beams observed in recent studies are different from those triggered by radiation generated using classical accelerators or sources, and this difference can be used to develop new strategies for cancer radiotherapy. High‐power lasers can now deliver particles in doses of up to several Gy within nanoseconds. The fast interaction of laser‐generated particles with cells alters cell viability via distinct molecular pathways compared to traditional, prolonged radiation exposure. The emerging consensus of recent literature is that the differences are due to the timescales on which reactive molecules are generated and persist, in various forms. Suitable molecular markers have to be adopted to monitor radiation effects, addressing relevant endogenous molecules that are accessible for investigation by noninvasive procedures and enable translation to clinical imaging. High sensitivity has to be attained for imaging molecular biomarkers in cells and in vivo to follow radiation‐induced functional changes. Signal‐enhanced MRI biomarkers enriched with stable magnetic nuclear isotopes can be used to monitor radiation effects, as demonstrated recently by the use of dynamic nuclear polarization (DNP) for biomolecular observations in vivo. In this context, nanoparticles can also be used as radiation enhancers or biomarker carriers. The radiobiology‐relevant features of high dose‐rate secondary radiation generated using high‐power lasers and the importance of noninvasive biomarkers for real‐time monitoring the biological effects of radiation early on during radiation pulse sequences are discussed.

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Exploring ultrashort high-energy electron-induced damage in human carcinoma cells

Abstract: International audienc

Cited by 63 publications

References 15 publications

Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

Comparison of measured with calculated dose distribution from a 120‐MeV electron beam from a laser‐plasma accelerator

Laser‐driven radiation: Biomarkers for molecular imaging of high dose‐rate effects

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