Exploring urinary biomarkers in autosomal dominant polycystic kidney disease

Kawano, Haruna; Muto, Satoru; Ohmoto, Yasukazu; Iwata, Fusako; Fujiki, Hiroyuki; Mori, Toyoki; Lu, Yan; Horie, Shigeo

doi:10.1007/s10157-014-1078-7

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…uNGAL levels were measured by ELISA as previously described [40], and uNAG was measured at the Special Reference Laboratory (SRL) (Hachioji, Japan). Values for uDA1, NGAL, and NAG are expressed as ng/mL, ng/mL, and U/L, respectively.…”

Section: Methodsmentioning

confidence: 99%

Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients

Chagan-Yasutan

Chen

Lacuesta³

et al. 2016

IJMS

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Leptospirosis is a zoonotic disease whose severe forms are often accompanied by kidney dysfunction. In the present study, urinary markers were studied for potential prediction of disease severity. Urine samples from 135 patients with or without leptospirosis at San Lazaro Hospital, the Philippines, were analyzed. Urine levels of defensin α1 (uDA1) were compared with those of neutrophil gelatinase-associated lipocalin (uNGAL) and N-acetyl-β-d-glucosidase (uNAG). Serum creatinine (Cr) was used as a marker of kidney injury. The levels of uDA1/Cr, uNGAL/Cr, and uNAG/Cr were positive in 46%, 90%, and 80% of leptospirosis patients, and 69%, 70%, and 70% of non-leptospirosis patients, respectively. In leptospirosis patients, the correlation of uDA1/Cr, uNGAL/Cr and uNAG/Cr levels with serum Cr were r = 0.3 (p < 0.01), r = 0.29 (p < 0.01), and r = 0.02 (p = 0.81), respectively. uDA1/Cr levels were correlated with uNGAL/Cr levels (r = 0.49, p < 0.01) and uNAG/Cr levels (r = 0.47, p < 0.0001) in leptospirosis patients. These findings suggest that uDA1, uNGAL, and uNAG were elevated in leptospirosis patients and reflected various types of kidney damage. uDA1 and uNGAL can be used to track kidney injury in leptospirosis patients because of their correlation with the serum Cr level.

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Section: Methodsmentioning

confidence: 99%

Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients

Chagan-Yasutan

Chen

Lacuesta³

et al. 2016

IJMS

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“…To our knowledge, this is the first work reporting an increase of HIF-1α and VEGF in ADPKD patients. Previous studies have also described higher urinary concentrations for MCP-1 in these patients [ 10 , 11 , 14 ]. However, unlike HIF-1α and VEGF, MCP-1 levels did not differ between groups in our study.…”

Section: Discussionmentioning

confidence: 54%

Association between urinary biomarkers and disease progression in adults with autosomal dominant polycystic kidney disease

Segarra-Medrano

Martín

Agraz

et al. 2019

Clinical Kidney Journal

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Background Height-adjusted total kidney volume (htTKV) is considered as the best predictor of kidney function in patients with autosomal dominant polycystic kidney disease (ADPKD), but its limited predictive capacity stresses the need to find new biomarkers of ADPKD progression. The aim of this study was to investigate urinary biomarkers of ADPKD progression. Methods This observational study included ADPKD patients, and two comparator groups of ischaemic and non-ischaemic kidney injury: benign nephroangiosclerosis patients and non-ischaemic chronic kidney disease (CKD) patients. Proteinuria, htTKV and urinary levels of molecules are associated with ischaemia and/or tubular injury. The slope of estimated glomerular filtration rate (eGFR) was used as a dependent variable in univariate and multivariate models of kidney function decline. Results The study included 130 patients with ADPKD, 55 with nephroangiosclerosis and 40 with non-ischaemic CKD. All patients had increased urinary concentrations of biomarkers associated with tubular lesions (liver fatty acid-binding protein, kidney injury molecule-1, β2-microglobulin) and molecules overexpressed under ischaemic conditions [hypoxia-inducible factor-1α, vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1)]. These biomarkers correlated positively with htTKV and negatively with the eGFR slope. htTKV was the single best predictor of the eGFR slope variability in univariate analyses. However, a multivariate model including urinary levels of β2-microglobulin, MCP-1 and VEGF improved the capacity to predict the decline of eGFR in ADPKD patients compared with htTKV alone. Conclusions The urinary levels of molecules associated with either renal ischaemia (VEGF and MCP-1) or tubular damage (β2-microglobulin) are associated with renal function deterioration in ADPKD patients, and are, therefore, candidates as biomarkers of ADPKD progression.

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“…Finally, Kawano et al (113) analyzed many urine biomarkers in patients with ADPKD and compared them with those in healthy controls. There were significant differences between healthy subjects and patients with ADPKD with respect to several biomarkers including von Willebrand factor, IL-8, macrophage colony-stimulating factor, interferon receptor 2, perpetual flowering 1, trefoil factor family 3, hepatocyte growth factor, multicopper oxidase-1, 8-hydroxydeoxyguanosine, NGAL, liver-type fatty acid-binding protein (L-FABP), angiotensinogen, and ceruloplasmin.…”

Section: Hyperphosphaturiamentioning

confidence: 99%